This dataset was used to analyse the hydrodynamic effects of floodgate closures in the Venice Lagoon under different management scenarios, namely: -The real-case "MoSE" scenario -The hypothetical unregulated "OPEN" scenario -The hypothetical regulated "AThOS" scenario Folder: 01_WaterLevels Contains .mat files with modelled water levels within the Venice Lagoon during floodgate closures between 2020 and 2023, for the OPEN, MoSE, and AThOS scenarios. Folder: 02_Maps Contains maps of salt marsh Mean Inundation Depth (MID) and Sedimentation calculated for the OPEN, MoSE, and AThOS scenarios. File: Supplementary.xlsx Contains additional information on model performance, records of floodgate closures, maximum water levels in the major urban settlements, and urban flooding.