All the data are listed in the text, references, and figures. Aerial photographs of the Venice Lagoon can be freely downloaded from the Copernicus Data Space Ecosystem (https://browser.dataspace.copernicus.eu). 5 m LiDAR DTM of the Sile Spillway can be freely downloaded from the Regione Veneto Catalogue https://idt2.regione.veneto.it/idt/downloader/download. ID:2733, name:12_2K_2807 Reference wind and tide data are freely available from the Centro Previsioni e Segnalazioni Maree (https://www.comune.venezia.it/node/7498) and the Istituto Superiore per la Protezione e la Ricerca Ambientale (http://www.venezia.isprambiente.it/rete-meteo-mareografica) websites. Figure3.xlsx – Contains: a) hydrometric riverine data measured in proximity of the Sile Spillway; b) Water levels measured at the tidal gauge station - Diga Sud Lido; c) Events of sustained high tide combined with maximum riverine water levels above the spillway. The historic hydrometric record of the Sile River has been provided by the Italian Ministero delle Infrastrutture e dei Trasporti – Provveditorato Interregionale alle OO. PP. del Veneto – Trentino Alto Adige – Friuli Venezia Giulia Figure4.xlsx – Contains: a) water levels measured at Diga Sud Lido gauge station; b) wind climate measured at the Laguna Nord – Le Saline anemometric station; c) Sile River water levels measured near the spillway; d) modelled freshwater discharge through the spillway. Figure5.xlsx – Contains both modelled and measured salinity at moored probes 8534 and 8549, allowing direct comparison for numerical reproducibility. Figure6.xlsx – Contains modelled salinity at points P1, P2, and P3 in the most surficial layers (14–11), located approximately at 200, 1500, and 3000 m from the river spillway, respectively. Figure8.xlsx – Contains modelled water levels and freshwater discharges for the 2019 non-regulated (OPEN) and regulated (CLOSED) scenarios. Figure9.xlsx – Contains freshwater discharge data for the six investigated scenarios. OPEN and CLOSED refer to the non-regulated and flood-regulated scenarios, respectively. TableS1.xlsx – Contains modelled lagoonal water levels for the 2019 OPEN scenario from eight stations used for model validation. WWTM and 3DEF indicate the hydrodynamic models from which the data were extracted. FigureS1.xlsx – Contains water vertical and lateral salinity variance. Vertical variance was investigated along the 14 vertical layers of the numerical model for three different locations P1, P2 and P3, located approximately at 200, 1500, and 3000 m from the river spillway, respectively. z_Boundary_Conditions.xlsx – Contains all data (water levels, wind climate, river discharges) used as input for the 2D and 3D numerical simulations. The "ShapeFiles" folder contains QGIS shapefiles for the salt marsh area and salinity thresholds for the 2019, 2060 SSP 4.5, and SSP 8.5 scenarios. The "TIFF folder" contains raster files used for replicating the images. Note: The area occupied by salt marshes was omitted from the calculations. The source code of the 'WWTM' hydrodynamic model can be provided upon request to users interested in contributing to the model development. The Venice Lagoon Bathymetry used in the numerical grid can be consulted at https://provveditoratovenezia.mit.gov.it/cartalaguna2023.html