Database clinico e metabolomica.xlsx: this file contains all the clinical information of all the patients (first sheet) as well as the metabolomic results (second sheet). 

Here is the legend for each column of the "Generale" sheet (clinical info) (Italian/English):
A ID: codice identificativo paziente; patient identification
B sesso: 0 F (femmina) 1 M (maschio); Sex: 0 female 1 male
C DN data di nascita; date of birth
D-E SG settimane gestazionali suddivise in settimana (D), giorno (E); week of gestation 
F PN peso neonatale in grammi, birth weight
G percentile del peso neonatale secondo Intergrowth21; centile of birth weight
H IUGR, ritardo di crescita intrauterino; intrauterine growth restriction
I SGA piccolo per età gestazionale; small for gestational age
J CC circonferenza cranica alla nascita in cm; head circumference at birth
K percentile della circonferenza cranica alla nascita secondo Intergrowth21; centile of birth head circumference
L lunghezza alla nascita in cm; lenght at birth
M percentile della lunghezza alla nascita secondo Intergrowth21; centile of birth length
N Parto: modalità di parto 0 vaginale, 1 taglio cesareo; type of delivery 0 vaginal, 1 caesarian section
O Gemellarità: gravidanza gemellare 0 no, 1 si; twin pregnancy
P Diabete materno 0 no 1 si; maternal diabetes
Q PPROM: prematura precoce rottura delle membrane 0 no 1 si; preterm premature rupture of membranes
R steroidi prenatali per induzione maturità polmonare 0 no 1 si; prenatal steroids for fetal lung maturity
S-U Indice di Apgar al 1° (S), 5° (T) e 10° (U) minuto di vita; apgar index at 1°,5° and 10° minutes of life
V CRIB SCORE: punteggio Clinical Risk Index for Babies Score; Clinical Risk Index for Babies Score
W Nazionalità dei genitori; parents' nationality
X-Y PIPP: valutazione del dolore secondo Premature Infant Pain Profile prima (X) e dopo (Y) il posizionamento del sensore glicemico; pain assessment with Premature Infant Pain Profile before and after glycemic sensor insertion
Z-AA Tempo di monitoraggio glicemico: Z inizio e AA fine; time of glucose monitoring
AB Insulina: terapia con insulina 0 no, 1 si; insuline therapy
AC-DN apporti nutrizionali suddivisi per nutriente (glucosio, lipidi, proteine), via di somministrazione (enterale OS e endovenosa EV) e ore di vita (HOB); nutritional intakes divided according to type of nutrients (dextrose, protein, lipid), way of administration (enteral and endovenouos) and hours of life
DO-EB Monitoraggio glicemico per tutta la durata del monitoraggio espresso come: percentuale di tempo in ipoglicemia severa (DO), ipoglicemia lieve (DP), normoglicemia (DQ), iperglicemia lieve (DR), iperglicemia severa (DS), numero totale di misurazioni (DT), ogni  misurazione eseguita ogni 5 minuti; glicemia minima in mg/dL (DU), glicemia massima in mg/dL (DV), glicemia media in mg/dL (DW), glicemia mediana in mg/dL (DX), deviazione standard SD (DY), 25° percentile (DZ), 75° percentile (EA), coefficiente di variazione CV (EB); glycemic monitoring for the entire time of monitoring: percentage of time in severe (DO) and mild (DP) hypoglycemia, euglycemia (DQ), severe (DS) and mild (DR) hyperglycemia, total number of misuration (DT) every 5 minutes, minimaum (DU) and maximum (DV)glycemia, average (DW) and median (DX) expressed as mg/dL, standard deviation (DY), 25° (DZ) and 75° (EA) percentile, coefficient of variation (EB)
EC-JZ Monitoraggio glicemico suddiviso per ore di vita: entro 72 ore di vita (EC-EP); dopo 72 ore di vita (QE-FD); prime 24 ore di vita (FE-FR); 24-48 (FS-GF); 48-72 (GG-GT); 72-96 (GU-HH); 96-120 (HI-HV), 120-144 (HW-IJ), 144-168 (IK-IX), 168-192 (IY-JL), 192-216 (JM-JZ); glycemic monitoring according to hours of life
KA IVH emorragia intraventricolare di 3° o 4° stadio 0 no, 1 si; intraventricolar hemorrage
KB EOS sepsi neonatale precoce 0 no, 1 si; early onset sepsis
KC LOS sepsi neonatale tardiva 0 no, 1 si; late onset sepsis
KD PNX pneumotorace; pneumotorax
KE ET DR necessità di intubazione in sala parto 0 no, 1 si; endotracheal intubation in delivery room
KF NEC enterocolite necrotizzante 0 no, 1 si; necrotize enterocolitis
KG SURF <24h surfactant somministrato entro 24 ore di vita 0 no, 1 si; surfactant administration before 24 hours of life
KH SURF dosi tot: numero totale di dosi di surfactant somministrate; total number of surfactant administration
KI O2 36 PMA: ossigenoterapia a 36 settimane post mestruali 0 no, 1 si; oxygen therapy at 36 post mestrual age
KJ BPD: displasia broncopolmonare 0 no, 1 si; broncopulmonary dysplasia
KK Steroidi post: terapia steroidea postnatale sistemica per la BPD; postnatal steroids
KL ROP retinopatia della prematurità espressa in base al grado; grade of retinopathy of prematurity
KM Calo ponderale espresso come percentuale del peso neonatale; weight loss
KN Mortalità a 28 giorni di vita; mortality at 28 day of life
KO Mortalità alla dimissione; mortality at discharge
KP Durata del ricovero in giorni; lenght of stay (day)
KQ insertion site: reazione nel sito di posizionamento del sensore glicemico 0 no, 1 si; adverse reaction in insertion site of glycemic sensor
KR-KS: pervietà del dotto arterioso emodinamicamente significativo HSPDA 0 no, 1 si (KR) e suo trattamento medico (KS) con 0 ibuprofene o 1 paracetamolo
KT-LB parametri auxologici (peso, lunghezza e circonferenza cranica): valore assoluto di peso (in grammi), circonferenza cranica (in cm) e lunghezza (in cm), percentili secondo Intergrowth21, EUGR (ritardo di crescita extrauterino) 0 no, 1 si; auxological parameters at discharge as absolute number, centile and EUGR
LE-LL Follow up a 12 mesi di età corretta: LE-LF l'età corretta in mesi (LE) e giorni (LF), LG-LL parametri auxologici espressi come valore assoluto (peso in kg, lunghezza e circonferenza cranica in cm) e centili secondo gli standard CDC; follow up assessment at 12 month corrected age: corrected age at assessment; growth parameter as absolute number and centile
LM-LT Follow up a 24 mesi di età corretta: MI-MJ età corretta in mesi e giorni; MK-MP parametri auxologici come valore assoluto e centile secondo CDC; follow up assessment at 24 month corrected age: corrected age at assessment; growth parameter as absolute number and centile.

Here is the legend for each column of the "Metabolomica plasma" sheet (metabolomics) (Italian/English):
A: identificativo campione, sample identification
B: codice identificativo paziente, patient identification
C: tempo raccolta campione, timepoint sample collection
D-I: metaboliti pattern chinurenine, kynurenine-pathway metabolits
J-AT: amino acids
AU-BG: acyl carnitine metabolits
BH-BR: organic acids

Abbreviations:
UPLC cromatografia liquida ad ultra prestazione/ultra-performance liquid chromatography
APGC cromatografia gassosa a pressione atmosferica/atmospheric pressure gas chromatography
5-HIAA acido 5 idrossi-indolacetico/5-hydroxyindoleacetic acid
GABA acido gamma-amminobutirrico/gamma-aminobutyric acid
NMMA NG-metil-L-arginina/NG-methyl-L-arginine
SDMA dimetilarginina simmetrica/symmetrical dimethylarginine
ADMA dimetilarginina asimmetrica/asymmetric dimethylarginine
DOPA diidrossifenilalanina/dihydroxyphenylalanine

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CGM.xlsx: this file contains all the CGM data. Each sheet refers to a patient and contains all the CGM data of that patient. You can find the date of acquisition, the time (one sample every 5 minutes) and the CGM value. The first part of the table refers to the initial calibration of the device.

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PDXX.zip: contains a folder for each patient (PDXX, with XX its number) containing all the nirs files (.nirs) for that patient. The nirs files are named with the date of acquisition and the starting time and an increasing number (from none to _X) which indicates the order of the files. The NTS device saves a file every 50 minutes. For some patients, the acquisition might have been interrupted and restarted later on, and therefore two subsets of .nirs files will be found in the folder.

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Neurodevelopment.zip:

1) Gap-Overlap task at 12 and 24 months 

Files included: 
1.	gapoverlap_12months_fullterm.xlsx – 12-month full term infants 
2.	gapoverlap_12months_preterm.xlsx – 12-month preterm infants 
3.	gapoverlap_24months_fullterm.xlsx – 24-month full term infants
4.	gapoverlap_24months_preterm.xlsx – 24-month preterm infants

These Excel file contain the full-term and preterm infant dataset for the Gap-Overlap task assessed at 12 and 24 months of age. Manual coding of saccades was performed using VirtualDub, except for the last 6 preterm infants at 24 months, who were coded using VirtualDub2. All data and variable labels are in Italian.
Each worksheet corresponds to a single participant. Participant worksheets include trial-by-trial coding of the Gap-Overlap task, with saccadic latencies measured in milliseconds (ms). Trials with latency ≥1000 ms or < 80 ms are excluded from analyses. Invalid trials are noted in the NOTE column with explanations for exclusion (e.g., participant not looking at screen, blinks). This file allows computation of mean latencies for Gap and Overlap conditions and the Gap-Overlap effect for each participant.

Columns/Variables (in Italian):
•	DATA TEST: date of assessment.
•	DATA NASCITA: participant’s birth date.
•	ETÀ: participant’s age in months at the time of testing.
•	TRIAL: sequential trial number.
•	TARGET ON / POSIZIONE: timestamp (ms) and target position (DX or R = right, SX or L = left).
•	SACCADE ON / POSIZIONE: timestamp (ms) when the participant started a saccade and the initial gaze position/direction.
•	ACCURATEZZA: accuracy coding (1 = correct saccade, 0 = incorrect).
•	LATENZA: saccadic latency in milliseconds.
•	NOTE: comments on trial validity or participant behavior (e.g., looking away, blinking).
•	GAP / OVERLAP: trial type.
•	TRIAL VALIDI / TRIAL TOTALI: number of valid and total trials per condition.
•	GAP-OVERLAP EFFECT: calculated as the difference in latency between Gap and Overlap trials.


2) Simultaneous Stream Change Detection task at 12 months 

Files included: 
1.	vstm_12months_fullterm.xlsx – 12-month full term infants 
2.	vstm_12months_preterm.xlsx – 12-month preterm infants 

These Excel file contain the full-term and preterm infant dataset for the Simultaneous Stream Change Detection task assessed at 12 months of age. Manual coding of saccades was performed using VirtualDub. All data and variable labels are in Italian.

For each participant, there are two Excel sheets:
1.	Sheet (I) – initial coding of the full task
2.	Sheet (II) – coding for analysis, selecting only the 10-second observation window for each phase
Only fixations of at least 3 consecutive stimuli are considered. If the infant does not maintain fixation for the full 10 seconds, actual fixation time is recorded. Very brief fixations (<80 ms) are excluded. Only valid blocks containing at least one Set Size 1 and one Set Size 2 are included in the analyses.

Columns/Variables (in Italian):
•	STIMOLO: block/phase number
•	ON: stimulus onset
•	ENGAGE: start of fixation on the stimulus
•	DIR: fixation direction (SX or L = left, DX or R = right, C = center)
•	DETECTION: duration of the fixation
•	DISENGAGE: end of fixation
•	DIR: direction at disengagement
•	OFF: stimulus offset
•	NOTE: additional notes (e.g. blink) 
•	SET SIZE 1/ SET SIZE 2: fixation duration per set size
The sheets report total fixation time (TOT) and relative percentages (%) for each flow, as well as additional indicators such as TOTAL LOOKIN TIME (TTF or TLT) and ORIENTATION (OR) where applicable.

3) Visual Short Term Memory task at 24 months 

Files included: 
1.	vstm_24months_fullterm.xlsx – 24-month full term infants 
2.	vstm_24months_preterm.xlsx – 24-month preterm infants 

These Excel file contain the full-term and preterm infant dataset for the Visual Short Term Memory task assessed at 24 months of age. Manual coding of saccades was performed using VirtualDub, except for the last 6 preterm participants, who were coded using VirtualDub2. All data and variable labels are in Italian.
Only valid blocks containing at least one Set Size 2 and/or Set Size 3 are included in analyses. Trials where saccades were unclear or the infant looked away are marked in the “Note” column and excluded from statistical analyses.

Columns/Variables (in Italian):
•	DATA DI NASCITA: participant's date of birth.
•	DATA TEST: date of assessment.
•	ETA’: participant’s age in months at the time of testing.
•	NUMERO TRIAL: sequential trial number.
•	SET SIZE: number of stimuli presented in the memory array (2 or 3)
•	STIMOLO VARIABILE: position of the first variable stimulus.
•	1' SGUARDO: direction of the infant's first fixation for each trial.
•	MEMORY ARRAY / TEST ARRAY: timestamps of stimulus presentation.
•	ENGAGE: start of fixation on the stimulus
•	DIR: fixation direction (SX or L = left, DX or R = right, C = center)
•	DETECTION: duration of the fixation
•	DISENGAGE: end of fixation
•	DIR: direction at disengagement
•	TEMPO R / TEMPO L / TEMPO C: cumulative fixation time on Right, Left, or Center stimuli.
•	TEMPO CUMULATIVO 3 STIMOLI: cumulative fixation duration across three consecutive stimuli.
•	CP (Change Preference): proportion of total fixation time spent looking at the stimulus that changed color.
•	CP (Non-Change Preference): proportion of total fixation time spent looking at stimuli that did not change color.
•	Note: comments on trial validity or participant behavior (e.g., looking away, blinking)
•	MEDIA CP / MEDIA NCP: mean CP (change preference) and NCP (no change preference) across valid trials.
•	TLT: task’s total looking time (sum of all fixation durations).
•	1' SGUARDO = ST. VAR: number of first fixations directed on the variable stimulus.
•	1' SGUARDO ≠ ST. VAR: number of first fixations directed elsewhere.

4) Bayley-III scores at 12 and 24 months 

File included: 
•	bayley_12months_24months_fullterm_preterm.xlsx – Bayley-III scores for full-term and preterm infants assessed at 12 and 24 months
This excel file contains the complete dataset of Bayley-III assessments for infants evaluated at 12 and 24 months of age, using corrected age for preterm infants. All variable labels are in Italian.
 
The file includes four worksheets, each corresponding to a group (full-term vs. preterm) and age at assessment: 
1.	fullterm_12months – Full-term infants assessed at 12 months
2.	preterm_12 months – Preterm infants assessed at 12 months
3.	fullterm_24 months – Full-term infants assessed at 24 months
4.	preterm_24 months – Preterm infants assessed at 24 months

Each worksheet contains Bayley-III scores for individual participants. For each Bayley domain (Cognitive, Language, Motor, Socio-emotional), the following metrics are reported: raw score, scaled scores, composite scores, percentile ranks, and 95% confidence intervals. 

Columns/Variables (in Italian): 
•	subj: participant ID
•	Punteggi Grezzi (raw scores): 
o	Cognitive (cognitive)
o	Recettivo (receptive language)
o	Espressivo (expressive language)
o	Fine (fine motor)
o	Grosso (gross motor)
o	Socioemozionale (socio-emotional)
•	Punteggi scalati (scaled scores): same subscales as aboce, standardised scores
•	Punteggi compositi (composite scores):
o	Cognitive (cognitive)
o	Linguaggio (language)
o	Motorio (motor)
o	Socioemozionale (socio-emotional)
•	Rango percentile (percentile rank)
•	Intervallo di confidenza (95%) (95% CI) for each composite score