This repository contains a selection of output variables from two different lumped parameter models of the cardiovascular circulation. 
The two models differ for the level of detail of the systemic circulation:
-the condensed model (CM) is characterised by a  single compartment representing the systemic circulation,
-the extended model (EM) is characterised by a more detailed description of the systemic circulation with 6 different compartments 
 (i.e., upper body, splanchnic district, renal district, reproductive organs district, left and right leg).

The simulated subject has a body surface area (BSA) of 1.9 m² and a heart rate (HR) of 75 bpm.

Three different conditions are considered:
- the physiological condition (physio folder)
- the cardiogenic shock condition (cs folder), that is characterised by reduced left ventricular contractility
- the cardiogenic shock condition supported by VenoArterial ExtraCorporeal Membrane Oxygenation (cs_ECMO folder), that represents the pathological condition supported by the VA-ECMO device

The repository contains the following folders:

-subject_CM_physio.zip 	contains the variables representing a physiological condition in the condensed model
-subject_CM_cs.zip 	contains the variables representing a cardiogenic shock (cs) condition in the condensed model
-subject_CM_cs_ECMO.zip contains the variables representing a cardiogenic shock (cs) condition supported by VA-ECMO 
			(VenoArterial ExtraCorporeal membrane Oxygenation) in the condensed model
-subject_EM_physio.zip 	contains the variables representing a physiological condition in the extended model
-subject_EM_cs.zip 	contains the variables representing a cardiogenic shock (cs) condition in the extended model
-subject_EM_cs_ECMO.zip contains the variables representing a cardiogenic shock (cs) condition supported by VA-ECMO 
			(VenoArterial ExtraCorporeal membrane Oxygenation) in the extended model

-Supplementary.zip	contains all the data needed to reproduce figures present in Supplementary materials.


Each folder contains the following variables in a matlab format:

-Pao 		: aortic pressure
-Plv 		: left ventricle (LV) pressure
-Vlv 		: left ventricle (LV) volume
-Prv 		: right ventricle (RV) pressure
-Vrv 		: right ventricle (RV) volume
-Qmv 		: mitral valve flow
-Qpua		: pulmonary arterial flow
-Qpv 		: pulmonary valve flow
-Q_vb_tot	: flow at the level of the systemic vascular bed
		  In the CM model the vascular bed is a single compartment
		  In the EM model the flow at the level of the systemic vascular bed is the sum of the flows at the level of the vascular bed in the 
		  six systemic districts present in EM (upper body, splanchnic district, renal district, reproductive organs district, left and right leg)
-Ppuve		: pressure at the level of the pulmonary veins

The folders related to the extended model also contain two additional variables describing the renal compartment:

-Pk		: post-capillary pressure in the renal disctrict
-Qk		: renal vascular bed flow

The repository also includes the following additional variables:

-SBP_CM_cs	: systolic blood pressure for different levels of impairment in the cardiogenic shock condition in the condensed model
-SBP_EM_cs	: systolic blood pressure for different levels of impairment in the cardiogenic shock condition in the extended model
-Elv_physio	: time-varying elastance curve that describes the mechanical beahaviour of the LV in a physiological condition in both the models
-Elv_CM_cs	: time-varying elastance curve that describes the mechanical beahaviour of the LV in the cardiogenic shock condition in the condensed model
-Elv_EM_cs	: time-varying elastance curve that describes the mechanical beahaviour of the LV in the cardiogenic shock condition in the extended model

The Supplementary folder contains two subfolders:

- dataFigureS1 that contains the pump head (Hp), the pump flow (Q_ECMO) and the MAP identified in EM and CM. These data are necessary to reproduce Figure S1 reported in the Supplementary materials
- dataFigureS2 contains the systemic-level outputs obtained with the extended model (EM). 
	Specifically, it includes the following variables:

	- `Qxxa_EM_typeSubject.mat`: flow in the arterial compartment of the systemic district `xx` for the specified subject 		type.
	- `Qxx_EM_typeSubject.mat`: flow in the microvascular compartment of the systemic district `xx` for the specified 	subject type.
	- `Pxx_EM_typeSubject.mat`: post-capillary pressure in the systemic district `xx` for the specified subject type.

	The subject type can be:
	- `physio`: physiological condition
	- `cs`: cardiogenic shock
	- `cs_ECMO`: cardiogenic shock supported by VA-ECMO

	The district abbreviations are:
	- `ub`: upper body
	- `spl`: splanchnic district
	- `k`: renal district
	- `ro`: reproductive organs
	- `lb_lr`: left and right legs