>GsuAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------------------------------------------WS-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ECP------------------------ --------------------SG--GSVFRIYAEKRER----------------GEK---- ----------------------------------------ISYKLW-------------K ELNYRLECE----------------------YIRLFVQ----EGRY-L------------ -------------ELDRSAS-LVKSTISIAFSHDGRYFASTHG----------------- -------------------------DHSVKVFEWPSGKQIATLEKHRRTPWT-------- ----------------VKFHPFK-RHILASGCIGNECCVWDLRD--GSCVRSQKFP-ASI SCLSFHPNGELIAVSSGSC-VFLWRYGFLRK--YSLR---KVPQLYNSSNTFRSLF---- --QPLNTKVRVCRDD-ED---------------------FSVLESSGE------------ --ESYEILKTPM-----PTLPYHMVQFHPSGQ-FLLTGE--------------------- ----KNRSS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AEL---------QFSLRFVLHRFDLEE--QTISTSSP VLI---------------IPRAIA------------------------------------ -------------------------------------------YN--------------- ------------DAGVDFSPCGKMIVACV------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PEED------------------------- ------------------------------------------------------------ --------------------NQM------------------------------------- ---------------------------------------------AFQIAIF-------- --------------SLVNRA-------------------------DGVL--MGDMLYSIP LDSAHLWALTNLK-----------------FSSSGS------------------------ ---------------------HLLAGFSFRSP---------SVT---------------- -------DMAKICLW-DSNNEFFKSETG-------------------------------- ------------------KADVIEIH-------HLHSKNR------------TSLVQT-- LQSDVIYDRINYTPSVED---------------------EINVA------LFSPGRTISG VVADGLIYGTQ----------------KG-RIRLFQLNK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >PuAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EPELPTTAAPAAA-PS-------------------- --------------A-------------------------SATAAYA------------A EAAAIACLG---------------------------------TGRY-L------------ -------------SMEKDPA-AVRSTISLAVAADGSRFASTHG----------------- -------------------------DTAVRVWDLPSGLLRATLHGHPRTPWT-------- ----------------VRWHPAE-RDVLASGCLGQQVRVWRVDT--GACTAVQAFP-AEI SGVAFHPAGDVLAVGTGRR-AFLWRYAA-------------------------------- ---PD------------------------------------------------------- S-TPVEVLNA--------IHPLRLVDFHPTGE-LLLVGR--------------------- ----KNQRP-----------------VTLASQFTLKLD------------------VHRF T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RH- --------------DGP-----------------------SDEAVCSG----------QD DEGR-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---H--ERPGVTA-----------------------------------TNTGGSSD---- --------P--------------------------------------------------- -----------------------SGGM--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AAWFGP---------------------- -----------------------------------------------------------S VLT---------------IPAAVA------------------------------------ -------------------------------------------YN--------------- ------------DAGVAFSPCGKMLAACIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------A--------------------------- ------------------------------------------------------------ ----------------------ATD------EETGNGA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------SVAHAGGVTPA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------APSDS------------------------- ------------------------------------------------------------ --------------------GEA------------------------------------- ---------------------------------------------GYRIAIL-------- --------------SLCPSS-------------------------------LGNCIASTP LDEGHTSALTNLC-----------------FSPTSG------------------------ ---------------------HLLAGFSFRPSNPHLRAAKDALA---------------- -------AAVAVAAQDDGN-ALPSGPSGAAEHCVVEPQGATAHVEGDSLETPASPQPVSA TKTAEGSSAARPAPPT---VPVVDIF-------SVED----------------GLRRVHR IHAGLRVTG-GGVHTIHD---------------------EINCA------VFASQSGA-- --DIAVIYGTQ----------------QG-LVRVVDGGQ--------------------- -------------------------------------------------------QAGST TGMT---------------V---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------EK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >CcrAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------N-IV------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RRRP------------------------ --------------------RA--TAGFSFVRDRETG----------------GEP---- -------------------------------------PTSPDLLSW-------------V EDNTLRRLD---------------------------------RGKY-V------------ -------------PLDRPDP-LVRSTISIAFSHDGRYFASTHG----------------- -------------------------DHSVKVFRYPSGEQIACLDGHPRTPWT-------- ----------------VRFHPKD-SSILASGCLGCECRVWDVSQ--GECIRKHTFA-SSI SCVSFNPDGSLLAITSGSN-LLLWNYME------------------AAPNNSRSTS---- ---------------------------------------------SAID------DIRGP G-VPRKLLGG--------VNPFHMVDFHPSGT-MLMTGE--------------------- ----KNRS---------------------------------------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------P------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TGA------ --------PSNQEE---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------QFTLKLVIHRFDRRI---VKKFDDP VLE---------------VPRAVA------------------------------------ -------------------------------------------YN--------------- ------------DAGIHFSPCGTMLAACI------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVHE------------------------- ------------------------------------------------------------ --------------------HSD------------------------------------- ---------------------------------------------SFKIAVM-------- --------------SLVKRN--------------------------QIK--IGTVMYETA LDRGHVTALTNLK-----------------FSSTSH------------------------ ---------------------HLLAGFSFRPKN--------PVLRGHA------------ -EHYDQTAGRGA----DGG----------------------------------------- -----------MRRPN--QVGVVDIY-------NVSEK--------------FEMIRS-- LRADMDLTE-GQEGGAED---------------------EINVA------VFAPVFGI-- --ADGVVYGTQ----------------KG-RIRMFQQATGADMKAEP------------- ---------------------CGES-HADS------------------------CSSSAW TGST-------ATTWSSHR----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --APYVVPP----------------ISRRQRLR-------------------------NT LVR------------------EQAPSG--------------------------------- ----------------DYR--------------------------------DTTPGSN-- ---------PVQ--------------LR-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >CreAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SLAKLLLARETE-NGATGRASRKAV---G------ ----------------------------------------AALECW-------------A ESDFLRHA----------------------------------TSEY-V------------ -------------DFRPSP----RSTIAAVFSPDGRHLASTHG----------------- -------------------------DHTVKVTDVASGRLIHSLQGHRRTPWV-------- ----------------VRFSPTD-PDVMASGSLDFTAVVWRIST--GQPIAKHDFG-KPI ASLAFDPSGMVLVVTAGHK-LYSWQYAQ-------------------------------- ---------------T-------------------------------------------- A-VPVKILKT--------RRSLRALHFHPTAPHILLTAE--------------------- ----VTERR------------AGPGGADGAGPVAVPL----------------------- ------------------------------------------------------------ -----------------------------------PPG---------------------- -----AVAGLA------------------------------------------------- ----------------------------------------------LVPR--AASAGR-- ------------A---PGTA------------------------------------REGR AEGQSMHP----------------------------QHAQQGGGGG------------SG GAAGD----------------VSMD------------GPDPAP-EEDPQDAVD------- ----------ELSAFIAA------------HNSSLGALPLRFFHQRHPQ----PQPQPPG --RPQQQHA--------------------------------------------------- ------------------------------------------------------------ -----------------------NAGLGAG------------------------------ --------------------QGQGQ----------------------------------- --AV-VRHQAQASGAGGAGGGRAGNG---------------------------------- ----------------------------------AATGAGTGAAHP-------------- ----------SVWSVVAPAAPVAHE----------------------------------- -----AGAAAA---------------------GDGSHAHNEGAAAAAGAG---------- ---------------------------------GGGGAGAGGSGAA--------LGLAAA WPM-----GLLRN---------LLTGVTGVISGAA-----------SSLGVGGAG----- --------GGAAAG-GGGGGSDSVQ----------------AHVGAAGHAAGGGGGSGGV SM-------GGPGAVAGAGGAPSVTAVGGAA--------------PGTGAADGGGP---- ---------------------------------------AQARAAGGGEANVV------- -AAAAAVAGSRLS-----VLSPVD-VIRHQSLGGGLRHAIPLVAPAVPPLPPPSLPPPLQ HLRGSGP-LTPAMQHL-SLQNGGVAAQALQAHHHQAAP---DGTHAPPDAYAVHMAAAAA AADAH--------------VAPYELTWGWDHRAEL-GPDELE----RARQHAVVSTPDL- ------------------PPAANHDT---------PCIVTVRLW--EFRDPSRELRRE-- LLV---------------LPRVVL------------------------------------ -------------------------------------------CS--------------- ------------EMGVHISPCGRYMVCCVVR--------------------DSPSEACSQ WQADQQA-----------------------------------------ARHAAVDRAAAA TRTHAAR--------------TEPSSPDGAAVATAVAPMQCDTEDGGDEAGDLRAADGHH AVVVGGQAAAAAPAATGDGDGGGGGSGGGAGICG-VE----------------------- ---AARVDSCRSVDMADAGPA-----------------GHEP------SGSVQAMAGGCA AGPHGEPSVAWHGGGGSGGGGAGME-DAQMHDDTATQACCQEREAAAQPGASSAGPQGAV GCGAGAGLGVAAESGLAKLGKQPSGRRRRARGRGAGSGAGAGAGAGAGSSAGAGPAGPCG VHQLLVAQEEEG--HPVEEGVGVGACEADGG---RLGVAADGELEAGAGE------ASAA GPQH----TVERAAARTAASRPGGDVGVGVGAGEYDSAGAAACRRMSAAAAA-------- ------------SVSMSGPNPGSGQAAAAAAAQQAPDHHPRRH------------SHTH- ------------HHGHPHQQGQGQGETGSAAGAA-------------------------- --------------AQGG-AAPAGPSRPPLPPAAAPAAAGAPGSHQPQQLHSQ------- -QPE-----PLAAPQPQPPQQPQSPGEGATPHMFASIKEKLAQQRSLDEAAGARSVAVAE WAPAAPGAGAGAGAGAARGAHQAAAPLTEELSPVVCERAAADSGAAAATMPPHWAVPGRE AGTPMGAAAAAGHAGGDAVTTAARPQAQPAATAAAQKASGHASGPFYELCIFYTGA-SPM APSNAAPAMPTPTPSTSAASV-AFPAAGSGAAASSRAAAAAATGAAAVGPHFGALLHARP VLAAH--CMTSLQ-----------------FSPTGR------------------------ ---------------------HVLVSYGRRHI---------SLC---------------- --------SLVA----CAE----------------------------------------- -----------QLAAV---HSVVEVY-------SVPD---------------MVLRRV-- ------------LLSTED---------------------EVNVA------VFNAFPGG-- ----GMAYGTK----------------EG-RLRLLRYDR--------------------- -------------------------------------------------------RPPLR SVI--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PFMPLPGSDSADGGAPRG------------ADGAATGLAEDE-------------DE LDL-GL-DQALWNGA-----VPLAGTG--------------------------------- ----------------DPH--------------------------------DGHPS---- ------------------------------------------------FFTRFP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >VcAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------KNIASLLLCRETN-QS-TFDRSNRGF----EQ---- ----------------------------------------SAVSRW-------------A EADFLRHS----------------------------------SSEY-V------------ -------------EFRPSP----RSSIAAAFSPDGRYLASTHG----------------- -------------------------DHTVKVTDVATGKVIHSLAGHRRTPWV-------- ----------------VRFSPVD-PDIMASGSLDFTAAVWQVST--GRMLHKYDFG-KPI ASLAFDPSGTTLVVSAGHK-VFSWPFTR------------------------R------- ------------------------------------------------------------ A-LPVKILKT--------RRSLRALHFHPTAPHILLTAE--------------------- ----VTERRAGGGGGGGGGAVAAAAAATAAAAGGGGGG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAADGAAAAA--------PSQPQQPPLPH--RHASHR-- ------------I---PQQY----------------------------------QQQYQY NTNSHHHHHHHHLTQTQM------------------AVLHQGGGGG----GGGGGAPAGD GA-------ATGGGGGGGGDGLHVH--------------------FNEQEAVD------- ----------DLAAFIAT-------------HNSAVV------------------AMAPP QQLPSDRQL--------------------------------------------------- -------LRP------------------------------------------QQLLQRFQ Q----------------------QQQLSQQ------------------------------ ------------------QPGQQQQ--------------------------------QQQ QLVV-DRTHTQAASAV-------------------------------------------- -------------------P---------------------------------------- -------------ADAFATHPHPHP---------------------------------H- ------------------------------------------------------------ ------------------------------------PHPQGAAVGPMGL----------- ------LRNLLTG--------GMVFRQAAAADGALA-------AEGSFATVHGAN----- --------PATAGG-GGGGGGGAGP----------------YIAHAAASAGGGGGGAPSV NPVAAGGGGDGRVTRGQNPYVAQSTPQGGSF--------------PAGGAATAG------ --------------------------------------RIAVQAGGGGRLN--------- --ILAPADILRHQ-----------------GLGGGVRHAIPLVAPAYMAAVPP------- -----------------------------------------------PPPPPLQDATASV SATALSPPPPPPPPPLDPHLEPYDLTWGWDHTAHMSES-EIA----RVRELALRIAPDL- ------------------PSAANHDT---------PCIVTVRLW--DFRDQARELKKE-- LLV---------------LPRVVL------------------------------------ -------------------------------------------CS--------------- ------------EMGIHFSSCGRYLVCCVVR--------------------DKPSDAGIR WQRNSHCSIGCACGGGGGGSLCCAVLCCAVLSCMQAAQLQSQTQTQTQAQTRVAVVAAQT PRTHVRHPGGPGTVMAVLGGGPERAGGDGAGRVGRLQCCQCDDEDNCDCGG--------- ----------FGFGFGGAGGAGGGGGGGSAGRCMEVEEEGGEEEEEEEEEQQATHAAVAV GTAAAAVTAA----ADAVIPPGSPGSCRSVEMVDMETRGRGPVQRRDCDGDDGGGGPGGG GGGGGERTVAWLGGGGGGGGEVHEEYDDENLYDTATQAYGREM----------------- -------LGVVVE--------------------GNGAAASGGWRGGPDSSTGG------- -----------------GGGGGGGSVAGDGGGDARRPAASALSLQQQQQQ------QAVR RPDHERDMAGQEAEARTEVSRPG----VAACEMEYDSAEAAAYCRMAAAASAISGVALGD GAEFGRREPGYSPISQGLSHPGGRAPAPSPQQQQQQQQHQQHHSPQLRPQNPHNPSHSHQ NRNRRSQQVKQPQHPPPQQQQQQQQQRGGQHPSLPHHQNHQNQNHHANHHPYRQSHQICQ QQQQHHAMERRSQHAQGGVSRTGRPTG---RPIGAAAAAAAAATAAAEAAHGTCGGGGGD AGPTYGAGGATAASVGLPPPPPPLPISRETPTTFASIKAHLARQRSRDGAA--------- ---ATTAAGAYGGGGSG---RDA--------------------GGAGGT----------- ---------VAGPEGDNAAAVTA-AMAMPAAAAAAAAP---ATATAFAARAT-------- ---AAVEGFAA---SYDATT-------------VAAAAAAAGGGISIVGPDFGLLLHARP VLAAH--CMTSVQ-----------------LSPAGD------------------------ ---------------------HLLVAYGRRHI---------SLC---------------- -------SLVSC----AGQ----------------------------------------- ------------LAAV---HSVVEIY-------SVPD---------------LRLRRV-- ------------LLSADD---------------------EVNVA------VFNAFPAE-- ----GMAYGTK----------------EG-RLRLMRYDR--------------------- -------------------------------------------------------RPPLR SAV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PFVALP--------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------HPSS--- --------------------------LSPGQ----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >Ms_RCC299AMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------FAQIRARELD-PT-GRL---------GQA-ARG GDPSTS---------GRRADPSFGSRVAPQHDPD-ASSLDRSLASW-------------A EADSLSNC----------------------------------TATY-S------------ -------------ELRPAP----RSTIAAAFSPDGRTLASTHG----------------- -------------------------DHTVKLIDCATGRCLATLAGHRRTPWV-------- ----------------VRFHPTN-PNVLASGSLDHEVRLWNART--SECVLRFDFG-KPI ASLAFHPEGDILAVASGHK-LYTWRYAAAMRADWEARIDGDVP---------RGDAMDAN AVHASSREGGL-REDTRDDAGGSRWTASAAYVGGFPSRSRGTVAGAMGAEGAEGADPDAL A-VPYISLRT--------RRSLRAVHFHPHGAPMLLSAE--------------------- ----VNETS------------EHDTAVPPLRAVT-------------------------- ------------------------------------------------------------ ----------------------------------APPP---------------------- -----AGEWET-------------------------------------------AYAAA- S-----------------------AAAAA------------------------------- ----------------------------------------------------------AM GGNG-------------------------------------GGLGG-----GGGHGLPSR GA-------ESGADGGGS------------------------------------------ -------------------------------RTTYIA----------------ARSSNPG --SPTLSSR--------------------------------------------------- ----------------------------------------------------PS------ -----------------------ADADDLD------------------------------ ----------------------ELA----------------------------------- --RL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------RVR-------------------------------------------- ------------------------------------SPANNAEAMD--------VDNQPG GED-------TRG--------------------------------------GGARRSR-- SSRGGRL-PTTA------------------------------------------------ -------------RQQLFQTPGASTST--------------------------------- ------------------------------------------------------------ --AAAAAATAAYQSAQN------------------------------------------- ----------------------ARGLRVLDPG---------------APTDQASRDAAAA AA------------------------------AAA------------------------- ------------------SADRAVDQ---------PCTVKLKIWRYDKKNPLAPL--SDA RLV---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRLLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- -------------------P---------------------------------------- ----------------------KDA------EDPAPG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------EPI--------------------------- ------------------------------------------------------------ --------------------PRL------------------------------------- ---------------------------------------------VYELRVY-------- --------------SLEEQN-------------------------------FGEVLAARS VRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HVLLAYGRRHS---------SLL---------------- --------LLVA----DGG----------------------------------------- -----------SCITV---HTILEVY-------RIAD---------------MSLVRV-- ------------LPSAED---------------------EVNVA------CFHPAAGG-- ----GLAYGTK----------------EG-RLRILRHDK--------------------- -------------------------------------------------------PPPRS ASK--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---RPMAIG---------------------RCL-----------E-------------DE LLE-------VL-------------DW--------------------------------- ------------------------------------------------------SG---- --------------------------LDADA----------------------------- ------------------------------------------------------------ ---------------------------------------------------DGLPNGNSG SDT------------------------------------------D-------------- --------------------- >CbAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------E-R---------------------------------WN-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------WQ--ENVARLLALREVY-PN-ARRTRRKLW---TVS-STR SSSECCAPGGGGRAAAAAAAAGGGGGRGGGSSPL-LLDCAKALELW-------------L EADSIRNF----------------------------------SAKY-C------------ -------------HLDPPP----RSTIAAAFSPDGSSLASTHG----------------- -------------------------DHTVKVVSCRTGACLKVLYGHRRTPWV-------- ----------------VRFHPLI-PQIVASGSLDNEVRLWDIGTGSGECFRSHDFG-RPI ASLAFHPHGEILAVASGHK-LYMWQYKK------------------------KREEH--- ------------------------------------------------------------ S-QPVIVLRT--------RKTLRAVHFHPYGAPLLLTAE--------------------- ----V---D------------SGESPQQLATSSSRPIS---------------------- ---RFF------------------------------------------------------ -----------------------------------PLP---------------------- -----A---SA-------------------------------------------CHPPP- H-----------------------SAPAAPHHLL-ANGFSVTPVF-PFGS---------W LL--------------PTLR-----------------NL--PRRVFSNTT--------TS DSPR------NDCHSREGMMMGGDRTAVAGQQGHRHRHHQRGGMGGRVNLGAAGASGGRD GG-------AQRLSNSSSSI-SDAR--------------------SRSAGEDTLDGVRDP D-PVGTGGGEEVSRRVAA----LLSRDG--GGDASHPSPM---------------DLSPA --VGGGSVGGNSSA----RMHTLDGGE---------------RDPDAVAAGGD------D VSRRVS--AP-----------LAKDGEEASHP--------------------SPMDFSPT GGGGGGGSL----------DGNSATRMDTL------------------------------ ----------------------DGVRDPDPAAT--GGAEEGSRGVSRDVGDAAHPSSAMA ASPAVDGSVGGNSATRMLDSDGAGS----------------------------------- -----------CPRNGM-----------------VG-AAMRSNL---------------- ---------------ENSGLPSGHGRPSSRARAAGEKAAGLRGGGGSATARARQYQEAHG GSGQALGGNSGREECRRDGNDVGAADRAWIPWGAWGGQTGAGTAAGQF------------ --------SGP-T-ESSPGLGLGLGMGMG-------MGG------P--------GDVLGG WEI-----PFVQQ---------VLQESQQ--------------------AAAGV------ --PG-TV-PGVRGN-EGAAGRRQSGGG-------------GSRNHAGEDRSGGAH---AP QQ--------QRPSQQHAAMPMASVAM--------------------------------- -------------------------------------------AAAVAAAR--------- ---AAARAGAGMLGAAGAGIGA--------GIGAQLG----------------------- --AGA-----------------ALGAAALSSGGGGDA-ATEAARHVQLDAAGAAGAAAAA VV----------------------------SMQAL------------------------- ------------------ASAQATES---------PCTVMLRIWPHDVQAPCDSLLAQKC KLV---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------A----------------------------------------- -----------------------ME------VRPSSSG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TGNGTGVGAQG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NY------GQRSPMELPCPPVSA------------------------- ------------------------------------------------------------ --------------------RNS------------------------------------- ---------------------------------------------MYELRVY-------- --------------SLEKHS-------------------------------FGQVLASRA VRAAH--CLTSIQ-----------------ISPTSS------------------------ ---------------------HVLLAYGRRHH---------TLL---------------- -------KSFSA----SGSG---------------------------------------- ----------KQLIPV---YTILEIY-------RISD---------------MSLVGV-- ------------LPSAED---------------------EVNVA------CFHSRVGG-- ----GLVYGTK----------------EG-RLRLMVHDR--------------------- -------------------------------------------------------QRRSS DSQ--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---SGF--------------------------------------E-------------DG VIH-------TR-------------MV--------------------------------- ----------------D-------------------------------------D----- --------------------------LH---------------------FDEGW------ ------------------------------------------------------------ ----------------------------------------------------LFHDGA-- ------------------------------------------------------------ --------------------- >MpAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------M-----------PS----------------------WP-------D GA-SG------------------------------------------------------- ------------------------------------------------------------ ----------------------------SSS-ASAS----TSQS---P--------CARY ---HPYARKRH---------PG--ENVLRLLAWREVA-PT-VKRPLRRLW---GEA-ATW SVSCS------------------------GYQRE-VTDAKMALVTW-------------L EAESLSHS----------------------------------TAKY-C------------ -------------PLQPAP----RSTIAAAFSPDGNTLASTHG----------------- -------------------------DHTVKIICCRTGFCLKVLSGHRRTPWV-------- ----------------VRFHPGS-SEVLASGSLDNEVRLWDANT--AECVGSRDFH-RPI ASLAFHAQGDLLAVASGHK-LYIWQYTK------------------------EGEA---- ------------------------------------------------------------ A-SPIIVLRT--------RRSLRAVHFHPHAAPLLLTAE--------------------- ----VNDLD------------SPDCPMTLATSRGLA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------NGSNDT- ---------------------QTDVALGE-----------NSAA---------------- ----------------P---------------------------------------ADRH DDAE----------------------------------------------------DGSN GA-------IE----------LERD--------------------SSLQLHTT------- -------------------------------EFSSAA-PM---------------DLSPR ---PTHVDS--------------------------------------------------- ---------------------------SAAST--------------------SG------ -----------------------ENKCEVP------------------------------ ----------------------ETELPNSLS-----VQDFGAEQTREGL----------- --AL-AGDPGRSSPTVVGAPWDVGE----------------------------------- ---------PPMYP--------------------VSSRTTNGSSSR-------------- -------------G------PVIPV----------------------------------- ---------------------------------ARRHVDSGGSGPGPG------------ --------IWP-I-TAFSNLNSASMT----------GGPSGPHFVP--------SADYST WDL-----PVLHG---------WVQGQQAGLAQPQS-------FSTVAGLQSGL------ --SGGMT-PQN-----------EGRAS-------------------------------QP HH----------SQQQNAPATVASAAL--------------------------------- -------------------------------------------AALATAAR--------- ---I---------GAGNSHIGPG--------VR-QIGN---------------------- --PSP-----------------GRG-------------------------------IQFP LST--------------------------VDPAGA------------------------- ------------------AQAALADI---------PCTVKLRIWPHDIRRPSALLDPETC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------PPE------SEMQGQGQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------RNMNGSPGGGNTVH------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTQ---HPISS------------------------- ------------------------------------------------------------ --------------------QQV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGQVLASRA VRAAH--CLTSIQ-----------------FSPTSG------------------------ ---------------------HILLAYGRRHN---------SLL---------------- -------RSLVV----DGS----------------------------------------- -----------RTIPI---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPMVGG-- ----GLVYGTK----------------EG-KLRILRHDR--------------------- -------------------------------------------------------TPRHL KPR--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---RVHEL------------------------------------E-------------DE LLE------QAE-------------TA--------------------------------- ----------------D-------------------------------------P----- --------------------------LS---------------------FGMLP------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DIE------------ --------------------- >PpAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------M-----------PS----------------------WL-------D GS-RG------------------------------------------------------- ------------------------------------------------------------ ----------------------------SSS-PSTS----KSNHQSPP--------CARY ---HPYARKQQ---------LG--GNVTRLLALREVA-PS-VKRPARWLW---GKA-ASG SAVHA------------------------GPRLE-STSAKLAITSW-------------V EAESLRYC----------------------------------TAKY-C------------ -------------PLQPAP----RSTIAAAFSPDGNTLASTHG----------------- -------------------------DHTVKIICCRTGQCLKVLSGHRRTPWV-------- ----------------VRFHPAS-SEVLASGSLDNEVRLWNANT--AECVGSRDFH-RPI ASLAFHAQGDLLAVASGHK-LYIWQFTK------------------------AGDV---- ------------------------------------------------------------ --SPTIVLRT--------RRSLRAVHFHPLAAPFLLTAE--------------------- ----VNDLD------------SPDCPMTLATSQGYLHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AIHFTP-------------------------------------------STSST- --------------------LLPNHSVSN-----------QVSFV-PLPS---------W FW--------------P---------------------------------------VLTT GSDL--------IFQTDLPTAVE---------------------------------AGDD GN-------VNFAEDSTSPI-AESELNVDT--------GRP---SLMTELQFP------- -------------------------------DFSSPA-PM---------------DISPR ---PVHDDV--------------------------------------------------- ---------------------FGDSTANDVST--------------------SG------ -----------------------REPLEEG------------------------------ ----------------------EIL-ENNES-----INDFNSQSRLN------------- -----AHDRIR------GAPWEIGG----------------------------------- ---------STSHPASI-----------------PPAGYSNTASTR-------------- -------------GPSSIPIPIPSS----------------------------------- ---------------------------------TSPRQDSGGAALGPA------------ --------VWP-M-SAFPNLNTQMLGGAS------GGIPSFQNFLP--------VGEYTG WEL-----PFLHG---------WVQGQQA---------------------QAGT------ --APSVV-PST--------VPVSGPWQ-------------------------------SA QE----------QQQQNAAISVASVAI--------------------------------- -------------------------------------------AAAVAAAR--------- ---TAARAGAGVVGAPNAGIGAD--------IGA-------------------------- --AGS-----------------GVSSRMGSSH---------GITIPGRGG-ANIGAAEAA AA----------------------------QAAMA------------------------- ------------------AAAAAAEL---------PCTVKLRIWPHDIKRPCATLDPETC RLV---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------MAD------SDSRR------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GNTTGSPAPGSSAH------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTQ---HPISS------------------------- ------------------------------------------------------------ --------------------QQV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGQVLASRA VRAAH--CLTSIQ-----------------FSPTSG------------------------ ---------------------HILLAYGRRHN---------SLL---------------- -------RSLVV----DGS----------------------------------------- -----------ATIPIR-VYTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPQVGG-- ----GLVYGTKDANKYLFNQQNLALIQEG-KLRILRHDR--------------------- -------------------------------------------------------TPLYL NPR--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----SGL------------------------------------E-------------DE LLE-------AE-------------TL--------------------------------- ----------------D-------------------------------------P----- --------------------------LS---------------------FGMVA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DIGNTL--------- --------------------- >PpAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------M-----------PF----------------------WP-------D ES-RG------------------------------------------------------- ------------------------------------------------------------ ----------------------------SST-TSTS----KSTHHSLP--------CGRY ---HPYSRKKQ---------LV--GNVTSLLAWREVA-PR-VKRPARRLW---GEA-ASG IVVHA------------------------GPRLE-SISAELALTSW-------------L EAESLRHC----------------------------------TAKY-C------------ -------------PLQPAP----RSTIAAAFSPDGNTLASTHG----------------- -------------------------DHTVKIICCRTGQCLKVLSGHRRTPWV-------- ----------------VRFHPAS-SEVLASGSLDNEVRLWNANT--AECVASHDFY-RPI ASLAFHAQGDLLAVASGHK-LYIWQFTK------------------------GGGA---- ------------------------------------------------------------ --APTIVLRT--------RRSLRAVHFHPLAAPLLLTAE--------------------- ----VNDLD------------SPDCPMTIATSQGYLHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AIHFTP-------------------------------------------STSST- --------------------LPSNSSLSN-----------QASFM-PLPS---------W FW--------------P---------------------------------------VLAT GSDL--------MFQSDPTVAVE---------------------------------VRDD GN-------TEFAEDSVSPI-TETELNIDT--------GRP---SLLTELQFP------- -------------------------------DSSSPA-PM---------------DISPR ---PVHDDV--------------------------------------------------- ---------------------FGDATANDVST--------------------SG------ -----------------------REPLEEG------------------------------ ----------------------EIM-ENNVT-----INGFDSQGRSQ------------- -----AHDRVR------GAPWDLEG----------------------------------- -----------SHPFT------------------SSAGYNNTGSAR-------------- -------------GHSSTPIPIPTS----------------------------------- ---------------------------------TSPRQDNGVETPGPT------------ --------AWP-M-GAFSNLNAQILAGAS------VGMPSFQNFLP--------VGEYPG WEL-----PFLHG---------WVQGQQA---------------------QAGT------ --APSGP-PSS--------VPAPGPWQ-------------------------------SA QE----------QQQQNAAVSVASVAI--------------------------------- -------------------------------------------AAAMAAAR--------- ---AAARAGAGMVGAASASLGAG--------IGAQIGIGTP-----------------MG AATGS-----------------GVNARIGPSH---------GIAIPGRGG-ATIGAAEAA AA----------------------------QAAMA------------------------- ------------------AAAAAAEL---------PCTVKLKIWPHDIKRPCALLDPATC RLV---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------MVD------SESRR------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GNTTGSPAPGSSAH------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTQ---HPISS------------------------- ------------------------------------------------------------ --------------------QQV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGQVLASRA VRAAH--CLTSIQ-----------------FSPTSG------------------------ ---------------------HILLAYGRRHN---------SLL---------------- -------RSLVV----DGS----------------------------------------- -----------ATIPIR-VYTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPQVGG-- ----GLAYGTK----------------EG-KLRILRHDR--------------------- -------------------------------------------------------TPLHL NPR--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----SGL------------------------------------E-------------DE LLE------LAE-------------TL--------------------------------- ----------------D-------------------------------------P----- --------------------------MS---------------------FGMVP------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------AVEDTH--------- --------------------- >CpAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------M-----------PS----------------------WL-------D EP-RG------------------------------------------------------- ------------------------------------------------------------ ----------------------------SSS-TSTT----KSTSHSPP--------CGRY ---HPYARKKL---------IG--GNVMRLLAWREVA-PT-VRRPIRRLW---GDS-ASG SVVHA------------------------GPRLE-ATSAKLALISWF----------YRL EAESLRHC----------------------------------AAKY-C------------ -------------PLQPAP----RSTIAAAFSPDGNTLASTHG----------------- -------------------------DHTVKIICCRTGQCLKVLSGHRRTPWV-------- ----------------VRFHPAS-SEVLASGSLDNEVRLWNANT--AECVGSRDFY-RPI ASLAFHAQGDLLAVASGHK-LYIWQFTK------------------------AGDA---- ------------------------------------------------------------ --APTIVLRT--------RRSLRAVHFHPLGAPFLLTAE--------------------- ----VNDLD------------SPDCPMTVATSQGYLHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AIHFTP-------------------------------------------STSTT- --------------------LLFNPSLSN-----------QQSIV-PLPS---------W FW--------------P---------------------------------------VLTT GSDL--------MFQTDPSIAAE---------------------------------VPDD GH-------ADFAEDSISPI-VASELEIDT--------GRP---SQLTELQFP------- -------------------------------DSSSPA-PM---------------DISPR ---PLHDDV--------------------------------------------------- ---------------------FEEATANDVST--------------------SG------ -----------------------REPLEEG------------------------------ ----------------------EIL-ENNDT-----INSFGSQSRSH------------- -----AHDRVRGSPTVVGAPWDVGG----------------------------------- ---------SASQPSST-----------------TPAGYSNTGLGR-------------- -------------SSVSIPIPIPTS----------------------------------- ---------------------------------TAARQDSEGGMPGPS------------ --------VWP-M-SAFPNLNGQILGGAT------GGMPPFQSFLP--------VGEYTG WEL-----PFLHG---------WAQGQQP--------------------VQTGS------ --VPSGA-PPS--------VPVSGPQQ-------------------------------SA QE---------QQQQQHAAVSVANVAM--------------------------------- -------------------------------------------AAAMAAAR--------- ---AAARAGAGMVGAASAGLGAG--------IGAQIG----------------------- --VGS-----------------GVGGRTGSNQ---------GMAIPGRGG-ATIGAAEAA AA----------------------------QAAMA------------------------- ------------------AAAAAAEL---------PCTVKLRIWPHDIKRPCAPLDPETC RLV---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------MAD------SDRR------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GNATGSPCPGTSAH------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTQ---HPISA------------------------- ------------------------------------------------------------ --------------------QQV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGQVLASRA VRAAH--CLTSIQ-----------------FSPTSG------------------------ ---------------------HILLAYGRRHN---------SLL---------------- -------RSLVV----DGS----------------------------------------- -----------ATIPIR-VYTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPQVGG-- ----GLVYGTK----------------EG-KLRILRHDR--------------------- -------------------------------------------------------TPLHL NPR--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----SGL------------------------------------E-------------DE LLE-------QE-------------TM--------------------------------- ----------------D-------------------------------------P----- --------------------------LS---------------------FGMVP------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DIEEAL--------- --------------------- >CpAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------L--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------LF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------IPYV-------- ----------------VRFHPAS-SEVLASGSLDNEVRLWNANT--AECVGSRDFY-RPI ASLAFHAQGDLLAVASGHK-LYIWQFTK------------------------AGDA---- ------------------------------------------------------------ --APTIVLRT--------RRSLRAVHFHPLGAPFLLTAE--------------------- ----VNDLD------------SPDCPMTVATSQGYLHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AIHFTP-------------------------------------------STSTT- --------------------LLFNPSLSN-----------QQSIV-PLPS---------W FW--------------P---------------------------------------VLTT GSDL--------MFQTDPSIAAE---------------------------------VPDD GH-------ADFAEDSISPI-VASELDIDT--------GRP---SQLTELQFP------- -------------------------------DSSSPA-PM---------------DISPR ---PLHDDV--------------------------------------------------- ---------------------FEEATANDVST--------------------SG------ -----------------------REPLEEG------------------------------ ----------------------EIL-ENNDT-----INGFGSQSRSH------------- -----AHDRVRGSPTVVGAPWDVGG----------------------------------- ---------SASQPSST-----------------TPAGYSNTGLGR-------------- -------------SSVSIPIPIPTS----------------------------------- ---------------------------------TAARQDSEGGMPGPS------------ --------VWP-M-SAFPNLNGQILGGAT------GGMPPFQSFLP--------VGEYTG WEL-----PFLHG---------WAQGQQP--------------------VQTGS------ --VPSGA-PPS--------VPVSGPQQ-------------------------------SA QE--------QQQQQQHAAVSVANVAM--------------------------------- -------------------------------------------AAAMAAAR--------- ---AAARAGAGMVGAASAGLGAG--------IGAQIG----------------------- --VGS-----------------GVGGRTGSNQ---------GMAIPGRGG-ATIGAAEAA AA----------------------------QAAMA------------------------- ------------------AAAAAAEL---------PCTVKLRIWPHDIKRPCAPLDPETC RLV---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------MAD------SDRR------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GNATGSPCPGTSAH------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTQ---HPISA------------------------- ------------------------------------------------------------ --------------------QQV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGQVLASRA VRAAH--CLTSIQ-----------------FSPTSG------------------------ ---------------------HILLAYGRRHN---------SLL---------------- -------RSLVV----DGS----------------------------------------- -----------ATIPIR-VYTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPQVGG-- ----GLVYGTK----------------EG-KLRILRHDR--------------------- -------------------------------------------------------TPLHL NPR--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----SGL------------------------------------E-------------DE LLE-------QE-------------TM--------------------------------- ----------------D-------------------------------------P----- --------------------------LS---------------------FGMVP------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DIDEAL--------- --------------------- >SfAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------M-----------PF------------------------------CD ERFGG------------------------------------------------------- ------------------------------------------------------------ ----------------------------SSS-KQTS----ASTSHLPS---------AQY ---HPF-WKCH---------VG--GNVVRLLAWREVT-PV-TRRPLRRLW---HKA-AAW SGCCT------------------------QSQLE-ATDAKRALISW-------------L EAESLRHC----------------------------------TAKY-C------------ -------------TLEPAP----RSTIAAAFSPDGNTLASTHG----------------- -------------------------DHTVKIICCQTGLCLKVLSGHRRTPWV-------- ----------------VRFHPSS-SEVLASGSLDNEVRLWDATT--AECVGSRDFY-RPI ASLAFHSQGDLLAVASGHK-LYIWQFTK------------------------EGEG---- ------------------------------------------------------------ A-VPIVVLRT--------RRSLRAVHFPPHAAPFLLTAE--------------------- ----VNDLD------------SPDCPMTMATSHAHMHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AIYFAP-------------------------------------------PASSI- S--------------------------------------PSVPSV-PFPQ--------PW FW--------------P---------------------------------------GQSG FGSN------LGLIQSDDEITASF--------------------------------LMLD PD-------QDFGRDSVSTI-LATDLGFET--------SSPWLAQDSHDIQFP------- -------------------------------DLTSPK-PV---------------DILAR ---PLPGES--------------------------------------------------- ------------------------SRESAITS--------------------NS------ -----------------------RLPSDRG------------------------------ ----------------------EMI-DYSETK---HLESYNSLDM--------------- --GL-GGNHGQSS-SIVRIPWDVEG----------------------------------- -------------PAAA-----------------VGTHWMNGTSSR-------------- -------------NSPAQRAPAVPV----------------------------------- ---------------------------------AHRQHGIGDTRLAPR------------ --------SWPAT-----------------------PVSSSQEILP--------AGDCTG WEL-----PFLHG---------WVQGRQL--------------------AHAGLGLGE-- ATINRMG-PPQ------------------------------------------------- -----------QLEGQNEAVSIASSRV--------------------------------- ------------------------------------------MASASIRAE--------- ---NESQIDA----------------------------GII-----------------IV AMANA-----------------GAGMRVYPNQ---------GIPISRRGGTAGIGAAETA VA----------------------------QSAMA------------------------- ------------------AAVASAEL---------PCTVKLRIWPHDIKRPSALLDPEI- ------------------------------------------------------------ ------------------------------------------------------------ ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------AFD------AEYSILP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------ATVLGSPNFGTRAH------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTQ---HPIST------------------------- ------------------------------------------------------------ --------------------QQV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGQVLASRA VRAAH--CLTSIQ-----------------FSPTSG------------------------ ---------------------HLLLAYGRRHN---------SLL---------------- -------KSLIV----DGT----------------------------------------- -----------TTIPV---YTVLEVY-------RVAD---------------MELVRV-- ------------LPSVED---------------------EVNVA------CFHPQVGG-- ----GLVYGTK----------------EG-KLRILVHDR--------------------- -------------------------------------------------------SSRLL NPH--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----QGL------------------------------------E-------------DE LVE-------TE-------------TL--------------------------------- ----------------D-------------------------------------A----- --------------------------QS---------------------FGDI------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >SfAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------ATSHAHMHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AIYFAP-------------------------------------------PASSI- S--------------------------------------PSVPSV-PFPQ--------PW FW--------------P---------------------------------------GQSG FGSN------LGLIQSDDEITASF--------------------------------LMLD PD-------QDFGRDSVSTI-LATDLGFET--------SSPWLAQDSHDIQFP------- -------------------------------DLTSPK-PV---------------DILAR ---PLPGES--------------------------------------------------- ------------------------SRESAITS--------------------NS------ -----------------------RLPSDRG------------------------------ ----------------------EMI-DYSETK---HLESYNSLDM--------------- --GL-GGNHGQSS-SIVRIPWDVEG----------------------------------- -------------PAAA-----------------VGTHWMNGTSSR-------------- -------------NSPAQRAPAVPV----------------------------------- ---------------------------------AHRQHGIGDTRLAPR------------ --------SWPAT-----------------------PVSSSQEILP--------AGDCTG WEL-----PFLHG---------WVQGRQL--------------------AHAGLGLGE-- ATINRMG-PPQ------------------------------------------------- -----------QLEGQNEAVSIASSRV--------------------------------- ------------------------------------------MASASIRAE--------- ---NESQIDADVLKHQRCRIHSS--------LCFHQHEGII-----------------IV AMANA-----------------GAGMRVYPNQ---------GIPISRRGGTAGIGAAETA VA----------------------------QSAMA------------------------- ------------------AAVASAEL---------PCTVKLRIWPHDIKRPSALLDPEMC RLV---------------IPHAVWG-------------------------RAALVSKLPL I------------------------------------VDLVTLNK--------------- ------------SMTS---------TACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------AFD------AEYSILP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------ATVLGSPNFGTRAH------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTQ---HPIST------------------------- ------------------------------------------------------------ --------------------QQV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGQVLASRA ------------------------------FSPTSG------------------------ ---------------------HLLLAYGRRHN---------SLL---------------- -------KSLIV----DGT----------------------------------------- -----------TTIPV---YTVLEVY-------RVAD---------------MELVRV-- ------------LPSVED---------------------EVNVA------CFHPQVGG-- ----GLVYGTK------------------------------------------------- --------------------------------------------------------VLIW HPY--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >DcoAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------M-----------PS---------------------CFQ-------F DAGTGP--DF-------------------------------------------------- ------------------------------------------------------------ ----------------------------SNP-PFTC------------------------ ---QLHAPKKQ---------LG--ENVTRLLGRREVS-PS-IKRPLRRLW---GES-VAW SESCS------------------------GHRCE-TVDVKHALIRW-------------V EAESFKHA----------------------------------VAKY-C------------ -------------PLLPAP----RSTIAAAFSPDGKILASTHG----------------- -------------------------DHTVKIICCRSGDCLKVLSGHRRTPWV-------- ----------------VRFHPKI-SELLASGSLDYEVRLWDANT--AECVGSRDFN-RPI ASLAFHAQGDLLAVASGHK-LYIWQYKG------------------------EGEA---- ------------------------------------------------------------ S-TPNIVLRT--------RRSLRAVHFHPHAAPLLLTAE--------------------- ----VNDLD------------SPDCPMTPATSRGYQQH---------------------- ------------------------------------------------------------ -----------------------------------HFP---------------------- -----VVSLNYPTA----------------------------------------FRSQD- -----L------------------NNFAA-M--------PQQSV--SVPG---------W FWM-----------------------------------------------------GEGQ GYPN------LLFLQPEASVSQLA--------------------------------FEPS AL-------QLPEGFEATLQ------------------------DTNLSVHPP------- -------------------------------ESTAVA-PM---------------DISPR ---ASNVNGSLHNA-----------------------------QRRASTSGS-------- -YEH-----------------LQRIGQGSLSE-------------------VGA------ -----------------------DFVSRFA------------------------------ ---------------------GESE----------------------------------- --SL--ANSGRTNSNVVGADG--------------------------------------- -----------IEP---------------------------------------------- ------------------------------------------------------------ ---------------------------------SQTQSEQQQFFTPSSVP--------RS DGPP--------------------------------TQTRSTEVVPVG------SGIPTE AEI-----SLVNG------------GETH----------------------RGL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGRLHLPSLGL--AE EA------------------------------AAQ------------------------- ------------------AAITAAEL---------PCTVKLRLWPHDIKRPCALLDPETC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGTHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------SPD------LEACPQAR--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------FATAGIAGTGFSVQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------QQI------------------------------------- ---------------------------------------------IYELRIY-------- --------------SLEEIT-------------------------------FGEVLSSRA VRAAH--CLTSIQ-----------------FSPTSG------------------------ ---------------------HILLAYGRRHN---------SLL---------------- -------RGLAV----DGT----------------------------------------- -----------SPVPI---YTILEV----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >DcoAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MTPATSRGYQQH---------------------- ------------------------------------------------------------ -----------------------------------HFP---------------------- -----VVSLNYPTA----------------------------------------FRSQD- -----L------------------NNFAA-M--------PQQSV--SVPG---------W FWM-----------------------------------------------------GEGQ GYPN------LLFLQPEASVSQLA--------------------------------FEPS AL-------QLPEGFEATLQ------------------------DTNLSVHPP------- -------------------------------ESTAVA-PM---------------DISPR ---ASNVNGSLHNA-----------------------------QRRASTSGS-------- -YEH-----------------LQRIGQGSLSE-------------------VGA------ -----------------------DFVSRFA------------------------------ ---------------------GESE----------------------------------- --SL--ANSGRTNSNVVGADG--------------------------------------- -----------IEP---------------------------------------------- ------------------------------------------------------------ ---------------------------------SQTQSEQQQFFTPSSVP--------RS DGPP--------------------------------TQTRSTEVVPVG------SGIPTE AEI-----SLVNG------------GETH----------------------RGL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGRLHLPSLGL--AE EA------------------------------AAQ------------------------- ------------------AAITAAEL---------PCTVKLRLWPHDIKRPCALLDPETC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGTHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------SPD------LEACPQAR--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------FATAGIAGTGFSVQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------QQI------------------------------------- ---------------------------------------------IYELRIY-------- --------------SLEEIT-------------------------------FGEVLSSRA VRAAH--CLTSIQ-----------------FSPTSG------------------------ ---------------------HILLAYGRRHN---------SLL---------------- -------RGLAV----DGT----------------------------------------- -----------SPVPI---YTILEV----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >SmAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M-------DS-SLDGV--GMVSS---------------------CFE-------N N----------------------------------------------------------- ------------------------------------------------------------ ----------------------------AAG-VSGS----QASS---------------- ---CSQCQSKN---------LA--DNVLRMLDWRQIS-PS-VRRPSKRLW---RDT-AAS SSKCH------------------------GHSRE-TTNAKHALVNW-------------L EAESFKHS----------------------------------IAKY-C------------ -------------SLVPAP----RSTIAAAFSPDGLTLASTHG----------------- -------------------------DHTVKIICCQSGQCLKVLSGHRRTPWV-------- ----------------VRFHPSS-PEVLASGSLDYEVRLWNANT--AECVASRDFY-RPI ASLAFHARGDLLAVASGHK-LYIWQYTK------------------------EGDA---- ------------------------------------------------------------ A-CPNIVLRT--------RRSLRAVHFHPLAAPLVLTAE--------------------- ----VNDLD------------SPDCPMSVATSREYQVY---------------------- ------------------------------------------------------------ -----------------------------------PYT---------------------- -----ELHYSH------------------------------------------------- ------------------------PGGAA-------------------PQ--------NW IW---------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------TGDAQVQRE------- -------------------------------SLTTTA-PM---------------DISPR ---PSNAAV--------------------------------------------------- ----------------------------PPPS--------------------DG------ -----------------------MDPVETP------------------------------ ------------------------------------------------------------ --GL-VSETGRVSPTVVGGPWD-------------------------------------- ---------PLVLPEA-------------------ATGQVENISFG-------------- -------------GASALRVPLVPV----------------------------------- ---------------------------------ARRQEEAVEVGTGSG------------ --------IWP-I-GLFPNIQAYSMT----------GQTHLPRFLH--------VTEPVV LD------PFLQG---------WVRYDQ-------------------------------- --------PEN------------------------------------------------- -----------EGEPQHQPQPPEPSGT--------------------------------- ------------------------------------------RRGGRNAAE--------- -------GRTQHR----------------------------------------------- ----------------------AQGV--------------------SRPQFTGFGVAE-- --------------------------------AAV------------------------- ------------------TAATAAEL---------PCTVKLKLWPHDIKQPSALLDPETC KLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGTHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------PEA------EPAQGRT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------NGPGGPGFSVQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTQ---HPIST------------------------- ------------------------------------------------------------ --------------------QQV------------------------------------- ---------------------------------------------IYELRIY-------- --------------SLEEAT-------------------------------FGEVLASKA VRAAH--CLTSIQ-----------------FSPTSG------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------RSIVL----DGT----------------------------------------- -----------TTIPV---YTILEIY-------RISD---------------LKLVRV-- ------------LPSAED---------------------EVNVA------CFHPRVGG-- ----GLVYGTK----------------EG-KLRIIRRDW--------------------- -------------------------------------------------------ITNSF GSS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---RQHGL------------------------------------E-------------DQ LLE-------AE-------------TS--------------------------------- ----------------D-------------------------------------P----- --------------------------LT---------------------FGMVP------ ------------------------------------------------------------ ------------------------------------------------------------ GDG------------------------------------------D-------------- --------------------- >CriAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------S-SVDS------RK----------------------IG-------N DCFPG------------------------------------------------------- ------------------------------------------------------------ ----------------------------ENS-SLNG----AFP--------------SRY ---HPYAGRRQ---------RE--GNVTRLLSWREVS-PA-VRQPFRKFW---DRG-SR- --ELS------------------------GPRNHQAISAKLALNSW-------------V EAESLLHC----------------------------------SAKY-C------------ -------------PLQPAP----RSTIAAAFSPDGTILASTHG----------------- -------------------------DHTVKIICCKTGLCLKTLCGHRRTPWV-------- ----------------VRFHPSG-SDVLASGSLDNEVKIWDANT--ADCISSHDFY-RPI ASIAFHAQGDLLAVASGHK-LYIWQYNR------------------------HAED---- ------------------------------------------------------------ A-APNIVLRT--------RRSLRAVHFHPHGAPLLLTAE--------------------- ----VNGLD------------APDCSMAHATSPGYVHY---------------------- ------------------------------------------------------------ -----------------------------------PRP---------------------- -----AIFFAP-------------------------------------------LQKPVS DSNQQ----------------GNSPALNS-----------ESSL--SAPA---------W IW--------------P---------------------------------------AAWV TDNN------HGAMRVGNLMMDL------------------------------------S GM-------QRSPVQDTDTYLPDGD--------------------SLEYSG--------- -------------------------------LNSEPV-PM---------------DASPR ---PAQSDM----------------------------------QIETSVSDT-------- -VNHLP---------------YPSESNSMIES--------------------GV------ -----------------------DMLLRAA------------------------------ ----------------------EGQ----------------------------------- --AL-VDGHVSRSAVNGGPES--------------------------------------- -----------AHPHL-------------------------------------------- ----------------TRVLPR-------------------------------------- ---------------------------------SETRDSLLGVGVSSSV----------A EGPPDLANIWSNP-GIWSDVNIQLLVGEN-------MPVIAPSSFQ--------AGESSG WEL-----PFLQG---------WVMGQNQ----------------------AGHVQ---- --PNSLG-PQHGIL-VVPSIQFESRAH-------------------------------PA LQ---------F-HQRHGNTGTANMAR--------------------------------- -----------------------------------------------NLSR--------- ---TGASRASRYRGSGHRATVA-------------------------------------- --SAST----------------GPGPVHV------------GVLHGFASGDPNLGVVGPD T-------------------------------SSM------------------------- ------------------AAAAAAEL---------PCTVKLRIWPHDIKNPSAVLDPEKC LLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CI-------------------------- ------------------LP---------------------------------------- ----------------------PAD------SDALVFL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------RNQSNEASLSS------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPMSA------------------------- ------------------------------------------------------------ --------------------QHV------------------------------------- ---------------------------------------------IYELRIY-------- --------------SLEKAT-------------------------------FGQVLASRA IRAAH--CLTSIQ-----------------FSPASD------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSLIV----NGT----------------------------------------- -----------TTIPI---FTILEIY-------RVSD---------------MELVKV-- ------------LPSAED---------------------EVNVA------CFHPVVGG-- ----GLAYGTK----------------EG-RLRIFKPDR--------------------- -------------------------------------------------------SDPFS GLP--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---RMF--------------------------------------E-------------DH VFD-------AG------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >AcvAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------P-SSDT------RK----------------------LA-------S DSFSG------------------------------------------------------- ------------------------------------------------------------ ----------------------------ENS-SPQG----AST--------------SRY ---HPYSGRRH---------RE--GNVTRLLSWREVS-PA-VRRTFRKLW---DGP-TKC GTDAV------------------------GVKKHEAVNAKLALTSW-------------V EAESLLHC----------------------------------SAKY-C------------ -------------PLQPAP----RSTIAAAFSPDGTVLASTHG----------------- -------------------------DHTVKIICCKTGLCLKTLCGHRRTPWV-------- ----------------VRFHPSR-SDVLASGSLDNEVKIWDANT--AECISSHDFY-RPI ASIAFHAQGDLLAVASGHK-LYIWQYNR------------------------HAEDT--- ------------------------------------------------------------ A-SPSIVLRT--------RRSLRAVHFHPHGAPLLLTAE--------------------- ----VNGLD------------APDCPMTLASSAGYLHY---------------------- ------------------------------------------------------------ -----------------------------------PRP---------------------- -----AIFFTP-------------------------------------------VQQPAS DSGQR----------------GNLPGLNA-----------DAAL--PAPA---------W IW--------------P---------------------------------------AAWV SDNN------YGAVQMDNEMMDS------------------------------------N GV-------QQTPLPDTDTFLPESD--------------------TLEFSG--------- -------------------------------FNSEAV-PM---------------DASPR ---PAQGDI----------------------------------QAETYINES-------- -SFHLS---------------YLPEASNAMES--------------------GV------ -----------------------DMLLRAA------------------------------ ----------------------EGQ----------------------------------- --AF-TEGQGSRNPVSSGVEN--------------------------------------- -----------VYPNL-------------------------------------------- ----------------TRVLPR-------------------------------------- ---------------------------------SETRDSLLGVNLPSNV----------S EGPVDAAGIWPNS-GIWNDVNIQVLVGDN-------MPAMSQSPFQ--------VGESSG WEL-----PFLQG---------WVMGQTQ----------------------AGMAQ---- --PNLQA-PQHGIL-VVPSIPFESR----------------------------------G LQ---------H-QHRHGLTGISGAAR--------------------------------- -----------------------------------------------NLPR--------- ---TGNSRASRSRGAGHRGLAT-------------------------------------- --SGPG----------------GPGSVHV------------GVLHGFASRDPNLGMIAAD TS------------------------------TMA------------------------- ------------------AAAAAAEL---------PCTVKLRIWPHDIKNPSAVLDPGRC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------PAD------SEALVFL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------RNPSNEASLSS------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HSMSA------------------------- ------------------------------------------------------------ --------------------QQV------------------------------------- ---------------------------------------------IYELRIY-------- --------------SLEEAT-------------------------------FGEELASRA IRAAH--CLTSIQ-----------------FSPASD------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSLII----NGT----------------------------------------- -----------TTIPI---FTILEIY-------RVSD---------------MELVKV-- ------------LPSAED---------------------EVNVA------CFHPVVGG-- ----GLAYGTK----------------EG-RLRIFKPER--------------------- -------------------------------------------------------LDPVT GST--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---RPF--------------------------------------E-------------DH VFD-------VG------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >TpAMBRA1 MT--------------------------------------------EKEED--------- ------------------------------------------------------------ -----M--------T-S---------SS----------------------SP------PE G----------------------------------------------------------- ------------------------------------------------------------ ----------------------------ETA----------------------------- --PAECPSGRH---------VG--DNVLRLVAWREIS-PR-VKRPLRKLW---GET-ARW TVSSC------------------------RSRYE-LVDAKHGLISW-------------T EAESLRHC----------------------------------SAKY-C------------ -------------TLVPPP----RSTIAAAFSPDGHRLASTHG----------------- -------------------------DHTVKIICFQTGGCIKVLSGHRRTPWV-------- ----------------VRFHPFR-QEILASGSLDHQVRLWDANT--AECIGSRDFN-RPI ASIAFHAHGDFLAVASGHK-LYIWRHSA------------------------KGDA---- ------------------------------------------------------------ S-VPMIVLRT--------RRSLRAVHFHPHAAPILLTAE--------------------- ----VNDLD------------APDSPMTVATSHGYLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----DVFFTP-------------------------------------------VNIGR- DS-------------------SNPISTPS-----------LGPLM-PFPR---------L LW--------------P---------------------------------------HATV GSNN------MTLSQSDGLRVDS------------------------------------N AR-------ESEAENTETLQ-LVRE--------------------LDLQAR--------- -----------------------------------GT-PM---------------K---- --VPENANTSIF-------------------------------TGELLSESENPGRASEK MTNSRQHNEPENTVYESGVDMLLRAAERHMRD--------------------YQ------ -----------------------RDSLSIS------------------------------ ----------------------EVS----------------------------------- --N------QTGNLNRAEPGH--------------------------------------- ------------------------------------EELGESS----------------- ----------------ISRSPS-------------------------------------- ------------------------------------SQEGQMIRSSPI------------ --------LWP-L-NISQNVNVQLLL----------GGRQLNQFLP--------LGDQPG WEF-----SFLQG---------WVMGQTQ----------------------AGL------ --HP-VL-PTTGPT-HMQTIPSD----V----------------------------RITV AD---------Q-LQQNATVSLASATL--------------------------------- -------------------------------------------AAGMPTDR--------- ---IHGRSAGRHR-SRSRLNSQ-------------------------------------- --ASG-----------------GLGL---------------HLGTEG--AQPILSTAEAA AA----------------------------HEAFA------------------------- ------------------ATAAAAEL---------PCTVKLRIWPYDIKNPCASLDSKTC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------SQE------SDVGLLS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QSNFGPGGTAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------QQV------------------------------------- ---------------------------------------------VYELRIY-------- --------------SLEEAT-------------------------------FGEVLASRA IRAAH--CLTSIQ-----------------FSPTSA------------------------ ---------------------HILLAYGRRHN---------SLL---------------- -------RSIVV----DGT----------------------------------------- -----------DTVPI---YTILEIY-------RVSD---------------MKLVRV-- ------------LPSAED---------------------EVNVA------CFHPLVGG-- ----GLVYGTK----------------EG-KLRIINNSS--------------------- -------------------------------------------------------LHVEN GTG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------Y------------------------------------E-------------EN VFE--------------------------------------------------------- ------------------------------------------------------------ ---------------------------E-------------------------------- ------------------------------------------------------------ --------------------------------------------------------G--- ------------------------------------------------------------ --------------------- >TchAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-S---------SS----------------------SS------PE G----------------------------------------------------------- ------------------------------------------------------------ ----------------------------ESA-TGQW----ASTS---------------- --AVESPSGRH---------VG--ENVLRLVAWREIS-PR-VKRPLKKLW---GET-AKW AVSSC------------------------RSRYE-SMDAKHGLISW-------------T EAESLRHC----------------------------------SAKY-C------------ -------------TLVPPP----RSTIAAAFSPDGCRLASTHG----------------- -------------------------DHTVKIICCQTGACLKVLSGHRRTPWV-------- ----------------VRFHPFR-QEILASGSLDHQVRLWDANT--AECIGSRDFN-RPI ASIAFHAQGDLLAVASGHK-LYIWRHSE------------------------KGDA---- ------------------------------------------------------------ S-TPMIVLRT--------RRSLRAVHFHPHAAPILLTAE--------------------- ----VNDLD------------APDSPMTVATSHGYLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----DVFFTP-------------------------------------------VNIGR- DS-------------------AIPISSPS-----------LAPLM-PFPR---------L QW--------------P---------------------------------------HATV GSNN------MTVSQPDGLRVDS------------------------------------N AR-------EYEAENTETLQ-LVRE--------------------LDLQTR--------- -----------------------------------GT-PT---------------E---- --VPVDANT----------------------------------RPESLANSVNPGRVSEN MVNIRHHGEPENNVYESGVDMLLRAAEGHMQD--------------------RR------ -----------------------SDSLGVS------------------------------ ----------------------EVN----------------------------------- --NV-QLSSQTRTLSRSEPGR--------------------------------------- ------------------------------------EDLGESS----------------- ----------------MSRSPS-------------------------------------- ------------------------------------RQEAQMIRTGPV------------ --------LWP-L-NVSQSVNVQLLL----------GGRQLNQFLP--------LGDQPG WEF-----SFLQG---------WVMGQTQ----------------------AGL------ --NP-VL-PTTGQT-QMQTIPSD----V----------------------------RIYV AD---------Q-LQQNATVSLASAAM--------------------------------- -------------------------------------------TTGMPTDR--------- ---IHGRSVGRHR-SRSRLNSQ-------------------------------------- --AGT-----------------GVGL---------------HIGTEG--GQPILSTAEAA AA----------------------------HEAFA------------------------- ------------------ATATAAEL---------PCTVKLRIWPYDIKNPCASLDPKTC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------SQE------SEVGLLS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QSNFGAGGTAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------QQV------------------------------------- ---------------------------------------------VYELRIY-------- --------------SLEEAT-------------------------------FGEVLTSRA IRAAH--CLTSIQ-----------------FSPTSA------------------------ ---------------------HILLAYGRRHN---------SLL---------------- -------RSIVV----DGT----------------------------------------- -----------DTVPI---YTILEIY-------RVSD---------------MKLVRV-- ------------LPSAED---------------------EVNVA------CFHPLVGG-- ----GLVYGTK----------------EG-KLRIINNSS--------------------- -------------------------------------------------------LHPEI GT---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >CjAMBRA1 MYNETSIPKKERLPNPQQSVNNKQRGKKQKFIC------------GEKEKD--------- ------------------------------------------------------------ -----M--------T-S---------SS----------------------SP------PE G----------------------------------------------------------- ------------------------------------------------------------ ----------------------------ETA-TGQW----ASTS---------------- --AGEHPSGRH---------VG--DNVLRLVAWREIS-PR-VKRPLKKLW---GET-ARW TVSSC------------------------RSRYE-LVDAKHGLIQW-------------T EAESLRHC----------------------------------SAKY-C------------ -------------TLVPPP----RSTIAAAFSPDGHRLASTHG----------------- -------------------------DHTVKIICFQTGGCIKVLSGHRRTPWV-------- ----------------VRFHPFR-QEILASGSLDHQVRLWDANT--AECIGSRDFN-RPI ASIAFHAHGDLLAVASGHK-LYIWRHSA------------------------KGDA---- ------------------------------------------------------------ S-APMIVLRT--------RRSLRAVHFHPHAAPILLTAE--------------------- ----VNDLD------------APDSPMTVATSHGYLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----DVFFTP-------------------------------------------VNIGR- DS-------------------SIPISTPS-----------LGPLM-PFPR---------L LW--------------P---------------------------------------HATV GSNN------MTLSQSDGLRVNS------------------------------------N AR-------ESEAENTETLQ-LVRE--------------------LDLQAR--------- -----------------------------------GT-PM---------------E---- --VPENANTSIS-------------------------------TGESLSESVNHSRPSEN MANSRQHNEPENSVYESGVDMLLRAAERHMRD--------------------YQ------ -----------------------RDSLSIS------------------------------ ----------------------EVS----------------------------------- --N------QNVTLNRAEPGH--------------------------------------- ------------------------------------EELGESS----------------- ----------------ISRSPS-------------------------------------- ------------------------------------SQEGQMIRSSHI------------ --------LWP-L-NISQNVNVQLLL----------GGRQLNQFLP--------LGDQPG WEF-----SFLQG---------WVMGQTQ----------------------AGL------ --HP-VL-PTTGPT-HMQTIPSD----V----------------------------RITV AD---------Q-LQQNATVSLASATL--------------------------------- -------------------------------------------AAGMPTDR--------- ---IHGRSAGRHR-SRSRLNSQ-------------------------------------- --AGG-----------------GVGL---------------HIGTEG--AQPILSTAEAA AA----------------------------HEAFA------------------------- ------------------ATAAAAEL---------PCTVKLRIWPYDIKNPCASLDSKTC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------SQE------SDVGLLS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QSNFGPGGTAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------QQV------------------------------------- ---------------------------------------------VYELRIY-------- --------------SLEEAT-------------------------------FGEVLASRA IRAAH--CLTSIQ-----------------FSPTSA------------------------ ---------------------HILLAYGRRHN---------SLL---------------- -------RSIVV----DGT----------------------------------------- -----------DTVPI---YTILEIY-------RVSD---------------MKLVRV-- ------------LPSAED---------------------EVNVA------CFHPLVGG-- ----GLVYGTK----------------EG-KLRIINNSS--------------------- -------------------------------------------------------LHAEN GTG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------Y------------------------------------E-------------EN VFE--------------------------------------------------------- ------------------------------------------------------------ ---------------------------E-------------------------------- ------------------------------------------------------------ --------------------------------------------------------G--- ------------------------------------------------------------ --------------------- >AtrAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-----------QS----------------------WV-------D I----------------------------------------------------------- ------------------------------------------------------------ ----------------------------PNL-PSTP----ASPSNSPP-------VFAQY ---QPNSCTRQ---------SA--SNVFQLLTLREIS-PR-IKRSSKRLW---GEA-ARK NHDCS------------------------KRRCE-VLDAKRGLVSW-------------V ETESLRHF----------------------------------SAKY-C------------ -------------PLTPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDCQTGSCLKVLSGHRRTPWV-------- ----------------VRFHPGD-SEILASGSLDHEVRLWDANT--AECIGSRDFY-RPI ASIAFHAQGELLAVASGHK-LYIWQYNR------------------------RGDA---- ------------------------------------------------------------ S-SPTSVLRT--------NRSLRAVHFHPHAAPFLLTAE--------------------- ----VTDIN------------APDSSMTLATSRGYLQY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVFFAN-------------------------------------------MRSGS- G-----------------------LNSEAI-R------DNQVPLF-PYPC---------F FC--------------PA--------------------------------------AFVR DNER------NSPQPDNM-VVDT------------------------------------N SE-------QEITESSPSPH-LTTD--------------------LNAGNQ--------- -------------------------------DDSLSA-ST---------------NMRQQ --VPLSSNV----------------------------------ALDNVTANG-------- ---------------------FLSEAEV-------------------------------- ------------------------------------------------------------ ----------------------YGQ----------------------------------- --AG-DMFDRRNSPSTAESVDDARS----------------------------------- ----------------------------------------SLI----------------- ----------------VRSID--------------------------------------- ------------------------------------RQFADGMRATDD------------ ------------T-TFMERTNIQMLLRSV-------ALGQLHQFLP--------LGDPTC WEL-----PFIQG---------WLMGQTH----------------------AGF------ ------L-PVNDRS-QENTIVSRGSPDA------------------------------WA SD---------PQATANMDALLIASAI--------------------------------- -------------------------------------------AANASHSR--------- ---SSGRSGSRHR-SRSRSMAP-------------------------------------- --IVP-----------------GAGATFM------------NVGGEESIPQSGAGSMDAE LAA--------------------------APPSGA------------------------- ------------------ATAAAAES---------PCTVKLRLWHHDVQDPCKKLVEGRC CLT---------------VPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------HME------LDPGLQS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QVHHDLGGSAS------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPVSA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------VYELRIY-------- --------------SLEQAT-------------------------------FGLVLASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHN---------SLL---------------- -------RSIVV----DGA----------------------------------------- -----------TTVPI---YTILEVY-------KVSN---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPLAGG-- ----GLVYGTK----------------EG-KLRILQYDG--------------------- -------------------------------------------------------SHNTN SMS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---P-YYL------------------------------------E-------------EN VIE-------VQ-------------TY--------------------------------- ------------------------------------------------------A----- --------------------------ME----------------------C--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >NcAMBRA1 MQSDGA--------------------------C--------------GLRKQ-------- ------------------------------------------------------------ -----M--------T-----------QA----------------------WL-------D D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------ANA-LSTS----TSHTSSSR-------ACSQP ---QTYSCTKQ---------SR--GNVFQLLAWREIS-PQ-VKRSAKKLW---ANA-AVQ DSNYC------------------------RARCE-VIDAKQRLLSW-------------V ESESLRHL----------------------------------SAKY-C------------ -------------PLVPPP----RSTIAAAFSPDGRTLASTHG----------------- -------------------------DHTVKIIDCQTGSCLKVLSGHRRTPWV-------- ----------------VRFHPGH-PEVLASGSLDHEVRLWDANS--AECIGSRDFY-RPI ASIAFHAQGDLLAVASGHK-LYIWQYSR------------------------KGE----- ------------------------------------------------------------ S-SPSIVLRT--------RRSLRAVHFHPHAAPFLLTAE--------------------- ----VNDLD------------SPDSPITLATSPCYLHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVVFAN-------------------------------------------VHSAS- S-------------------QISDTGVTN-----------QAPMM-PFPC---------L LW--------------P---------------------------------------AAFV GEHV------WSSQQDSM-VIDS------------------------------------N TG-------PQTRE--SSLQ-LLAV--------------------TNTNNH--------- -------------------------------ENVAAM-SS-------------------- --LVSSSRN----------------------------------LPESISNHI-------- -------------------------AGNTRSE--------------------ST------ -----------------------ADMMETA------------------------------ ----------------------DGQ----------------------------------- --SF-DMLESRGMDNTMERPNDANNMS--------------------------------- ---------TLTEPPV--------------------PSVLNGT----------------- ---------------DHPQSPG-------------------------------------- ------------------------------------RQSSPATAGAST------------ --------INP-S-SISGNSNLQMLLRNI-------AVGHLHQFLP--------LGDPSC WEL-----SFLQG---------WLMGQSH----------------------AGM------ --HP-VL-PVSDGS-HGGSLGIRGIASN-----------------------------VMA FD---------SQAAQSVEASGASSAV--------------------------------- -------------------------------------------------MR--------- ---GGSRSNFRHR-SRSRVMTN-------------------------------------- --TSS-----------------GEGPAVATIE--------DNVPHTGGATLASDGAAPSS MS---------------------------------------------------------- ------------------AAAAAAEL---------PCTVKLRIWPHDIQNPCAPLDPHTC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------HVE------TDPGTQM---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QMHQDVVGAAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPIAA------------------------- ------------------------------------------------------------ --------------------HRI------------------------------------- ---------------------------------------------VYELRIY-------- --------------SLEEAT-------------------------------FGEVLASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHN---------SLL---------------- -------RSLVV----DGE----------------------------------------- -----------TTIPI---YTILEVY-------KVSD---------------MELVRV-- ------------LPSADD---------------------EVNVA------CFHPVVGG-- ----GLVYGTK----------------EG-KLRLLHYDG--------------------- -------------------------------------------------------PNNAN CMG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PGSSL------------------------------------D-------------DN MLE-------VQ-------------TY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------C--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >CkAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------S-----------QS----------------------WV-------D D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------VNV-PSTS----TSPSSSQP-------LFSQF ---PPPSTSKR---------RV--SNVFRLLAWREIS-PR-TKHLSKRLW---GEA-SKC SVDCN------------------------RVKSE-RRDPRHGLISW-------------V EAESLRHL----------------------------------SAKY-C------------ -------------PLVPPP----RSTIAAAFSYDGKTLASTHG----------------- -------------------------DHTVKIIDCLTGRCLKVLSGHRRTPWV-------- ----------------VRFHPLH-PEILASGSLDHEVRLWDTNT--AECTNYRDFY-RPI ASIAFHAQGELLAVASGHK-LYIWHYKR------------------------KGLT---- ------------------------------------------------------------ N-SPIIVLKT--------RRSLRAVHFHPHAAPFLLTAE--------------------- ----VNDLD------------APDCPMTIATSPGYLHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVLFAN-------------------------------------------AQTQV- R-----------------------PNLEA-----------NIPLM-PFPF---------M FW--------------P---------------------------------------TFVR HNGR------ASSQHDNR-PLSS------------------------------------T GG-------QQNVD--FSPQ-HQID--------------------STIGNQ--------- -------------------------------HYHMMS-PM---------------EMSPR --IPSISNP----------------------------------IPEDTSADI-------- ---------------------FLSEVENAASE--------------------FV------ -----------------------MDTVEAT------------------------------ ----------------------ESH----------------------------------- --RM-DRVRQIRPPSVSEMSDGTDN----------------------------------- -----------TLPP---------------------ALQSNGV----------------- ----------------ASEVTI-------------------------------------- ------------------------------------IQSRMGVEVVSG------------ --------IHP-T-NLPGNTDLQMLLRTA-------DGGQRQQFFP--------FGDPGC WEL-----PFLQG---------WLMGQSH----------------------AGL------ --NQ-VP-STNDFS-QENSFGIRGNGLD-----------------------------ISA SD---------FLASRNVEGQLASRAL--------------------------------- -------------------------------------------ATSFSQPR--------- ---ATTRSGSRHR-SRSRLMAQ-------------------------------------- --AGS-----------------GEGT-TI------------AIGNDESDPQPGARRIESE LA------------------------------TSL------------------------- ------------------AAAAAAEL---------PCTVKLRIWPHNIQDPCASLDADKC CLI---------------VPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFIAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------HP---------------------------------------- ----------------------RVE------ADPGLPS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QVQHDVTGVAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEKAT-------------------------------FGLVLASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSIVV----DGE----------------------------------------- -----------TTIPV---YTILEVY-------RVSD---------------MELVQV-- ------------LPSAED---------------------EVNVA------CFHPLVGG-- ----GLVYGTK----------------EG-KLRILQYDT--------------------- -------------------------------------------------------SRGSD CAG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---SSFFL------------------------------------E-------------EN MLE-------VP-------------TY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------G--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >CkAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-----------ES----------------------W--------G D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------VNV-ASTS----TSPSCRQS-------LFTQF ---PPPLTSRC---------GG--SNVFRLLAWREIS-PR-TKHLSKRLW---GET-SKC SVDNI------------------------VRNIE-ATDARHGLISW-------------A EAESLQHL----------------------------------SAKY-C------------ -------------PLVPPP----RSTIAAAFSHDGKTLASTHG----------------- -------------------------DHTVKIIDCHTGRCLKVLSGHRRTPWV-------- ----------------VRFHPVH-PEILASGSLDHEVRLWNANT--AECIGHRDFY-RPI ASIAFHAQGEILAVASGHK-LSICHYTK------------------------SGSL---- ------------------------------------------------------------ T-SPIIVLKT--------RRSLRAVHFHPHAAPFLLTAE--------------------- ----VNDLD------------ASDSPMTLATSPGYLHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----TVLFAN-------------------------------------------SQTQV- R-----------------------PNLEA-----------NVSLM-AFPC---------M FW--------------P---------------------------------------AYVG HYGR------PSLQHDNR-TFAA------------------------------------T IG-------QQNVD--SSPQ-LQVD--------------------SNMGSL--------- -------------------------------HNHLIS-PM---------------EMSPV --IPSSSNQ----------------------------------VPEDTSADI-------- ---------------------LLSEMENADSD--------------------FV------ -----------------------MDAMEIA------------------------------ ----------------------EGQ----------------------------------- --DT-DRVQQMISNDM-EMSNSTNN----------------------------------- -----------IPPP---------------------TLQSNGV----------------- ----------------ASRMPI-------------------------------------- ------------------------------------RQSRVGVEVTSG------------ --------TQP-S-SLPGNVDLQMLLRSA-------DSGQLQQNFP--------FGDPGC WEL-----PFLQG---------WLMGQTH----------------------AGL------ --NP-MP-SLNDTT-QENPSRIRGNGSD-----------------------------VSA SE---------LLVSHDMGAQL-SSAT--------------------------------- -------------------------------------------ATRFSQSR--------- ---VTVRSGARLR-SRSRLSAN-------------------------------------- --AGS-----------------GEGTASL------------GIANDESDPHPGVGRIESE LA------------------------------TSL------------------------- ------------------AAAAAAEL---------PCTVKLRIWQHSMQDPCALLDADKC RLI---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------RVE------PDPGLPS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QVQHDVTGVAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEKAT-------------------------------FGSVLASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSIVV----DGE----------------------------------------- -----------TAVPV---YTILEIY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPLVGG-- ----GLVYGTK----------------EG-KLRILQNEG--------------------- -------------------------------------------------------SHGSN CTS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---SNFLL------------------------------------D-------------EN MLE-------VP-------------TY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------C--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >LtAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------N-----------QS----------------------LV-------D D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------ANV-PSTS----NSQA-----------GLPHF ---PSPSTSRH---------GG--SNVFRLLAWREIS-HG-AKRLSRRLW---GGA-SKQ TVDCF------------------------GPKFE-VTDTRHGLISW-------------V EAESLRHL----------------------------------SAQY-C------------ -------------PLLPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDCQTGSCLKVLSGHRRTPWV-------- ----------------VRFHPVH-SEILASGSLDHEVRLWDANT--AECIGSRDFY-RPI ASIAFHAQGELLAVASGHK-LYIWHYNK------------------------RGET---- ------------------------------------------------------------ P-SPTIVLKT--------RRSLRAVHFHPHAAPFLLTAE--------------------- ----VNDLD------------APDSPMTLATSPGYLHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVFFAN-------------------------------------------VRTGV- L-----------------------PSLEA-----------KVPLM-PFPC---------L FL--------------P---------------------------------------TFVK HCGR------TSFQNDNR-ATSS------------------------------------T NG-------QQSADPSASPQ-LQTD--------------------SNGGNR--------- -------------------------------HDYLVT-PM---------------EMSPV --IPSSSNP----------------------------------VPEDTTATL-------- ---------------------LPSEMENEALD--------------------SA------ -----------------------MDPMETT------------------------------ ----------------------EVQ----------------------------------- --PM-DLVEQRSSPSTVERSDDANN----------------------------------- -----------SSPL---------------------IVQPNGV----------------- ----------------APWLPS-------------------------------------- ------------------------------------RHSRPGVEVASG------------ --------------NIPGNSDLQMLLRSV-------EVGQLHQFFP--------SADPAC WEL-----PFLQG---------WLMGQTH----------------------AGL------ --HP-VP-PLNDTP-QENSSAIRGNGIE-----------------------------TSA SG---------LLASRSSEAPLASSAM--------------------------------- -------------------------------------------AASVSQCR--------- ---GTGRSGSRHR-SRSRL-VP-------------------------------------- --AGS-----------------GEGATFV------------SIANDDIDPQSGVGRLESE LA------------------------------TSL------------------------- ------------------AAAAAAEL---------PCTVKLRIWPHNIQDPCAPLDAEKC RLT---------------VPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------RME------ADPGLPL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------HAHQDVSGVAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLERAT-------------------------------FGLVLASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSIVV----DGE----------------------------------------- -----------TTIPI---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPLVGG-- ----GLVYGTK----------------EG-KLRILQYDG--------------------- -------------------------------------------------------SHGTN CTG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PNFFL------------------------------------E-------------EN MLE-------VQ-------------TY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------C--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >AcomAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-----------QS----------------------WE-------D N----------------------------------------------------------- ------------------------------------------------------------ ----------------------------AKS-FAAS----GLPSSSHP-------VCPQ- ----SSQCANL---------RC--RNVVRLLALREIS-PR-AKRYSKRRW---GKT-SDG GVDST------------------------RLKFG-VIDAKHALYSW-------------V ESESLRHL----------------------------------TAKY-C------------ -------------PLLPPP----RSTIAAAFSSDGRTLASTHG----------------- -------------------------DHTVKIIDCQTGNCLKVLSGHRRTPWV-------- ----------------VRFHPLC-SEILASGSLDHEVRLWDA-------------H-RPI ASIAFHAKGEILAVASGHK-LFIWNYNK------------------------RGEA---- ------------------------------------------------------------ S-SPTIVLKT--------RRSLRAVHFHPCAAPFLLTAE--------------------- ----VNSID------------SSDPPLTLATSSGYLHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----TYYFAN-------------------------------------------TNPSL- L-----------------------SCTES-----------NEPRT-PS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PM---------------DISTG --EPSASNS----------------------------------IVKDASLSS-------- ---------------------SQTGMKVFTYF--------------------SA------ -----------------------IGITETT------------------------------ ----------------------EGQ----------------------------------- --SM---SQQTTSTVNFHY----------------------------------------- ----------------------------------------NGV----------------- ----------------SFMIPF-------------------------------------- ------------------------------------TQSRPGVAGASM------------ --------SFP-T-T-NGSNDLQMLLRDA-------EAPHLHQFIS--------FNDPSC WDH-----PFLQG---------WLMGQNH----------------------AHHATE--- -LES-LR-PES---L--------------------------------------------- -------------YRRNAEAQGAPPLV--------------------------------- -------------------------------------------ATAVGNSI--------- ---TSGQPESDHLRSIS------------------------------------------- --------------------------------------------------------IESG LP------------------------------TSL------------------------- ------------------ASAGVTEI---------PCTVKLRIWPHNIQDPCAPLDPDTC RLT---------------ISHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRYLVACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CL-------------------------- ------------------LP---------------------------------------- ----------------------HTE------SDPGTRS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------SMQLDAAWAAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPFST------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------IYELRIY-------- --------------SLEEET-------------------------------FGNVLASRA IRAAH--CLTSIQ-----------------FSSTSE------------------------ ---------------------HILLAYGRRHE---------SLL---------------- -------RSIVI----DRE----------------------------------------- -----------MTIPI---YTILEVY-------RVSD---------------MELVGV-- ------------LPSAED---------------------EVNVA------CFHPLPGG-- ----GL---------------------EG-KLRILQYDG--------------------- -------------------------------------------------------PQDGS PTT--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---ANSSV------------------------------------E-------------EN MLV-------VF-------------VS--------------------------------- ------------------------------------------------------G----- --------------------------LS----------------------QIEE------ ------------------------------------------------------------ ----------------------------------------------------SFREGSST IDQ------------------------------------------VCNR----------- --------------------- >BdAMBRA1 ------------------------------------------------MTE--------- ------------------------------------------------------------ -----M--------A-----------EN----------------------WI-------E G----------------------------------------------------------- ------------------------------------------------------------ ----------------------------SKH-TSAP----ASFSGSV----------PRY ---QTSSPRKS---------RQ--RNIFHLLSHREVS-PR-TKHQAKRHW---SKP-PTG DTGFT------------------------ELRYS-ASDAKHDLFSW-------------A ESQSLHRW----------------------------------SAKY-C------------ -------------PLQPPP----RSTIAAAFSSDGKTLASTHG----------------- -------------------------DHTVKIIDCQTGKCLKVLGGHRRTPWV-------- ----------------VRYHPLH-SDILASGSLDYEVRLWDANT--SDCIVSHDFH-RPI ASIAFHALGDILAVASGHK-LFIWKYNN------------------------REEV---- ------------------------------------------------------------ S-APSIILRT--------RRSLRAVHFHPHGAPYLLTAE--------------------- ----VNNLD------------AADSQLTRATSTGYANY---------------------- ------------------------------------------------------------ ------------------------------------PP---------------------- -----ALFFAN-------------------------------------------VNSRG- Y-----------------------PHLES-----------SM----SSPC---------L IW--------------P---------------------------------------AFLR DDGS------LYIPRGDL-ASSS------------------------------------T NV-------QQS--SPSLAQNLLAS--------------------DAENQQ--------- -------------------------------SDQFVT-PM---------------DICPG --EPSASND----------------------------------IVDNSS----------- -----------------------------AAG--------------------LS------ -----------------------AIQMHAD------------------------------ ----------------------RGQ----------------------------------- --TD-SRLQGSSSSSSLERSSARDD----------------------------------- -----------VPM----------------------ASTSTSV----------------- ---------------PIPAIAR-------------------------------------- ------------------------------------PS--GPAVNRLP------------ --------TNS-F-TTSSGLDVQMFLRNS-------EGGNHHHDL---------FSDSRS WEL-----PFLHG---------WLMAQNH----------------------TGV------ ------------------------------------------------------------ -----------------------PSSL--------------------------------- -------------------------------------------PIATGSTR--------- -------GSNRRYDSRPHA-FS-------------------------------------- --SVP-----------------GVGSSLL------------GPQIDEAEAHVASLGVGSE LT------------------------------TSL------------------------- ------------------FAAGAAEL---------PCTVKLRVWRHDIKNPCSALETAAC CLT---------------ISHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLVACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CM-------------------------- ------------------LP---------------------------------------- ----------------------QTE------GDQGSQL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVQYDSTGPGT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPLPS------------------------- ------------------------------------------------------------ --------------------HGV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGEILTSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSIIM----DGE----------------------------------------- ----------TTGIPV---YTILEVY-------RVSD---------------MELIRV-- ------------LPSAED---------------------EVNVA------CFHPSPGG-- ----GLVYGTK----------------EG-KLRILQHNG--------------------- -------------------------------------------------------ADAAS LGL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----NCFI------------------------------------E-------------EN MLE-------VQ-------------RY--------------------------------- ------------------------------------------------------A----- --------------------------LE-------------------------------- ------------------------------------------------------------ ---------------------------------------------------G-------- ------------------------------------------------------------ --------------------- >HvAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------A-----------EN----------------------WV-------E G----------------------------------------------------------- ------------------------------------------------------------ ----------------------------SKN-TSAP----TSFSGSP----------PGC ---HTASTRRS---------RQ--RNIFHLLSHREVS-PR-TKHQAKRHW---NKP-PAC GAGYS------------------------ELRYL-ATDAKHDLFSW-------------A ESQSLHRW----------------------------------SAKY-C------------ -------------PLMPPP----RSTIAAAFSSDGKTLASTHG----------------- -------------------------DHTVKIIDCQTGKCLKVLGGHRRTPWV-------- ----------------VRYHPLH-PDILASGSLDHEVRLWDANT--SDCIGSQDFQ-RPI ASIAFHARGEILAVASGHK-LFIWNYNR------------------------RGES---- ------------------------------------------------------------ S-APPIILRT--------RRSLRAVHFHPHGAPYLLTAE--------------------- ----VNNLD------------SADSQLTHATSTGYSNY---------------------- ------------------------------------------------------------ ------------------------------------PS---------------------- -----ALFFAN-------------------------------------------INSRG- Y-----------------------PHLES-----------NM----SSPC---------L IW--------------P---------------------------------------AFLR DDGS------LYIPRNDL-ASGS------------------------------------T NV-------QQS--SSSLAQNVLAS--------------------DAENQQ--------- -------------------------------SDHFVT-PM---------------DVCPG --EPSASS---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------D----------------------------------- -----------VQM----------------------PSTSNSL----------------- ---------------PLPAIAR-------------------------------------- ------------------------------------PS--GSAVDRMP------------ --------VNS-F-TT-SGLDVQMFLRNS-------EGGNHHHDL---------LSDSRS WEL-----PFLHG---------WLMAQSQ----------------------TGA------ ------------------------------------------------------------ -----------------------SSSI--------------------------------- -------------------------------------------PIPAGSTR--------- -------GSNRHYASRPHA-LA-------------------------------------- --SVP-----------------GVGNSLL------------GPH-DEAEARAASLGVGSE LA------------------------------TSL------------------------- ------------------FSAGAAEL---------PCTVKLRVWRHDIKNPCVALETKAC CLT---------------ISHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLVACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CL-------------------------- ------------------LP---------------------------------------- ----------------------QTE------GDQGSQL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVQYESTGAGT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPLPS------------------------- ------------------------------------------------------------ --------------------HGV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGEILTSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSIVM----DAE----------------------------------------- ----------TTGIPV---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPSPGG-- ----GLVYGTK----------------EG-KLRILQHNG--------------------- -------------------------------------------------------ADAAS MGL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----NCFI------------------------------------E-------------EN MLE-------VQ-------------RY--------------------------------- ------------------------------------------------------A----- --------------------------LE-------------------------------- ------------------------------------------------------------ ---------------------------------------------------G-------- ------------------------------------------------------------ --------------------- >OsAMBRA1b ------------------------------------------------MLE--------- ------------------------------------------------------------ -----M--------T-----------ES----------------------WI-------E GS---------------------------------------------------------- ------------------------------------------------------------ ----------------------------KNT--SAP----ESVSCSV----------SRY ---ESSPPRRL---------GK--RNIYHLLAQREIS-PR-TKHQAKNIW---SGS-PEC ATGSI------------------------ELAFW-VTDARHDLFSW-------------A ESQSLHRW----------------------------------SARY-C------------ -------------LLLPAP----RSTIAAAFSPDGRTLASTHG----------------- -------------------------DHTVKIIDCQTGKCLKVLLGHWRTPWV-------- ----------------VRYHPLH-PDIVASGSLDNEVCLWDAKT--SRCIGSHFFY-KQI ASIAFHAKGELLAVASGHK-LFIWDYNK------------------------RDEA---- ------------------------------------------------------------ S-DPPMILRT--------RRSLRAVQFHPNGAPYLLTAE--------------------- ----VNNLD------------SADSELTHATSSGYSNS---------------------- ------------------------------------------------------------ ------------------------------------PS---------------------- -----AVFFAI-------------------------------------------MNSAC- C-----------------------PYSES-----------RF----SSPC---------L IW--------------P---------------------------------------AYVR DDGS------ICLLRNDW-VSGS------------------------------------S DV-------QQ------------PS--------------------DSETQQ--------- -------------------------------AGHMVT-PM---------------DVCPG --EP-GVNN----------------------------------YDDEDS----------- -----------------------------ASL--------------------SN------ -----------------------RIEMHTP------------------------------ ----------------------SWQ----------------------------------- --NS-SRFHNSSAATDLHRIDIR------------------------------------- ------------QV----------------------SDLSSDT----------------- ---------------PNPEMPA-------------------------------------- ------------------------------------HS-RIDVPNSMP------------ --------MDL-F-AFSNTIDVQMFLRDV-------EAGHHHNNY---------TGGSHS WEL-----PFLQG---------WLMAQNR----------------------TGL------ --RA-TL-PNNEVI-GDLPIGGTAGTDN------------------------------VM NE---------SSNMYSFERVGPSSSI--------------------------------- -------------------------------------------PITTDSLR--------- -------GLSKHR----HM-LA-------------------------------------- --SVPG----------------GAGTSLQ------------GAQNGEAHVNVVSLGVGSE FA------------------------------TSL------------------------- ------------------FAGDGTEL---------PCTVKLRIWRHNIDNPCAVLAPEAC CLT---------------ISHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGTHFSPCGRFLVACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CL-------------------------- ------------------LP---------------------------------------- ----------------------QTE-----VGEHVSQS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVQYDSTGAGT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPLPS------------------------- ------------------------------------------------------------ --------------------RRV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEET-------------------------------FGTVLVSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHN---------SLL---------------- -------RGIFM----DGK----------------------------------------- -----------TTIPV---YTVLEVY-------RVSD---------------MELVRV-- ------------IPSAED---------------------EVNVA------CFHPSPGA-- ----GLVYGTK----------------EG-KLRIIQHNV--------------------- -------------------------------------------------------ADY-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >OsAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------A-----------EH----------------------WA-------E G----------------------------------------------------------- ------------------------------------------------------------ ----------------------------SKH-ASAQ----ASY--------------SRY ----QATSARS---------RQ--RNIFDLLAQREIS-PR-TKHQAKKLW---SKS-PGN DADSN------------------------ELRYA-ATDAKHDIYSW-------------A ESQSLHHW----------------------------------SAKY-C------------ -------------PLLPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDYQTGKCLKVLSGHRRTPWV-------- ----------------VRYHPLL-PDILASGSLDQEVRLWDAKT--SDCIGSQDFH-RPI ASIAFHARGEILAVASGHK-LYIWNYNK------------------------RDEA---- ------------------------------------------------------------ A-APTIILRT--------RRSLRAVHFHPHGAPYLLTAE--------------------- ----VNNLD------------SADSPLTLATSSGYSNY---------------------- ------------------------------------------------------------ ------------------------------------PS---------------------- -----AVFFAN-------------------------------------------INSRN- C-----------------------PHHEA-----------NS----SSPC---------L LW--------------P---------------------------------------AYLR DDGS------LCLIRNDL-VSSS------------------------------------T NV-------HQR--PSSLAQNPLAS--------------------DVENQQ--------- -------------------------------PDQLVT-PM---------------DVCPG --EPSTSHA----------------------------------SASGLS----------- ------------------------------------------------------------ -----------------------GVEMQID------------------------------ ----------------------RGQ----------------------------------- --PS-SRLLGSSSTSNHESSTARDD----------------------------------- -----------VQM----------------------PSLSNSV----------------- ---------------PIPATSQ-------------------------------------- ------------------------------------PS-EHDGRHGMP------------ --------MNS-F-TTSSGLDVHMILRNS-------EGGNHHHDL---------FSDSRS WEL-----PFLQG---------WFMAQNH----------------------TGA------ ------------------------------------------------------------ -----------------------SPSI--------------------------------- -------------------------------------------PIDVGSSR--------- -------GSNRHHASRRHV-VG-------------------------------------- --SLR-----------------GVGSSLL------------GPQIDEAEVHAASLGVGSE LT------------------------------TSL------------------------- ------------------LAAGAAEL---------PCTVKLRIWRHDIKDPCVTLEPEAC RLT---------------ISHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLVACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CL-------------------------- ------------------LP---------------------------------------- ----------------------QTE------GDRGSQL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVQYDSAGAGT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPLPS------------------------- ------------------------------------------------------------ --------------------HRV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGKVLTSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHN---------SML---------------- -------RSIVM----DGE----------------------------------------- -----------TGIPV---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPSPGG-- ----GLVYGTK----------------EG-KLRILQHNG--------------------- -------------------------------------------------------ADITS TGL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----NCFI------------------------------------E-------------EN MLE-------IQ-------------RY--------------------------------- ------------------------------------------------------A----- --------------------------LE-------------------------------- ------------------------------------------------------------ ---------------------------------------------------G-------- ------------------------------------------------------------ --------------------- >SbAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------------------EPRVPCG--------------------------D GGP-----EL--------RGTRRHRREGE------------------------------- ---------------------RIHVLDP----------------------------RILE P---------------------------QRQ-RSNPF----------------------- ------------------------RNIFHLLTQREVS-PR-TKHHAKRIW---NKS-PKY DPDLI------------------------ELRFA-DADAKLDIFSW-------------A ESQSLHRW----------------------------------TAKY-C------------ -------------PLLPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDCHTGKCLKVLSGHRRTPWV-------- ----------------VRYHPLH-SDILASGSLDHEVRLWDANT--SDCIGSQDFH-RPI ASIAFHGRGEILAVASGHK-LYIWNYNK------------------------RDDT---- ------------------------------------------------------------ S-FPAIILKT--------RRSLRAVHFHPHGAPYLLTAE--------------------- ----VNNIE------------SADSPLTLARSSGYSNY---------------------- ------------------------------------------------------------ ------------------------------------PS---------------------- -----ALLVTN-------------------------------------------TNSRF- C-----------------------PLPES-----------NV----MSPC---------L LW--------------P---------------------------------------AYLR DDGI------LHVLGND---SSS------------------------------------T IV-------QQR---SSLVQ-PSAS--------------------DTANVQ--------- -------------------------------LEQFAT-PM---------------DVCPG --EPTSSND----------------------------------ISDAVT----------- -----------------------------VPT--------------------SN------ -----------------------GIEMRGA------------------------------ ----------------------GSQ----------------------------------- --SN-SRLQGGSYISNLERFSARDD----------------------------------- -----------LQV----------------------SSLSSTE----------------- ---------------PIPSTAG-------------------------------------- ------------------------------------LS-GSVLRRAMP------------ --------LNM---LLTGGLDVQMFLRNI-------GSGQQDHSL---------FGDSHN WEV-----PFVQG---------FLMAQNH----------------------TGA------ ------------------------------------------------------------ -----------------------SSSI--------------------------------- -------------------------------------------PLTAGSSR--------- -----GLGPNRRYASR-------------------------------------------- --SVP-----------------GVGSLLL------------GPQIDEAEAHAASLGAGSE IT------------------------------ASM------------------------- -------------------LAPGTEL---------PCTVKLRIWRHDIKEPCVPLEPEAC RLT---------------ISHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLVACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CL-------------------------- ------------------LP---------------------------------------- ----------------------QTE------GDHGSQL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVPYE--GAGS------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPLPS------------------------- ------------------------------------------------------------ --------------------HRV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEET-------------------------------FGDILASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSIVV----EGE----------------------------------------- -----------NGIPV---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPSPGG-- ----GLVYGTK----------------EG-KLRILQHNG--------------------- -------------------------------------------------------ADMTN MGV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----GCFI------------------------------------E-------------EN MVE-------IQ-------------RY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------C--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >SbAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------A-----------EC----------------------QI-------Q DW---------------------------------------------------------- ------------------------------------------------------------ ----------------------------KHQHPSAP----DSV--------------SR- ---HEASIPRT---------RQ--RNIFGLLAQRELS-PR-TKNQAKNLW---TKP-PRR DACPV------------------------ELKFW-GTDARHDLLSW-------------A ESEFLRWW----------------------------------IPKY-C------------ -------------PLLPSS----KATIAAAFSPDGRVLASTHG----------------- -------------------------DHTVKIIDCQTGKCLNVLFGHQRTPWV-------- ----------------VRFHPQR-SDILASGSLDCEVRLWDAKT--SRCTAVLAFY-RPI ASIAFHATGELLAVASGHK-LFIWDCNN------------------------RRET---- ------------------------------------------------------------ L-EPPIILKT--------RRSLRAVQFHPHGAPYLLTAE--------------------- ----VHNLD------------SEDSTMTPALLSNYSFR---------------------- ------------------------------------------------------------ -----------------------------------DTP---------------------- -----LLGGSG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------VDNLIS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -EL-----SYMHN-------------FEQ----------------------VGA------ ------------------------------------------------------------ -----------------------SSSV--------------------------------- -------------------------------------------PVTTSSFD--------- -------GSRLHDTSGHHL-TT-------------------------------------- --SVP-----------------GIGSSLL------------GTHTAEAEAPAISLSVGAE QT------------------------------TSL------------------------- -------------------LGGGTEL---------PCTVKLRIWRHNMKNPFIALGPEAC LLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGTHFSPCGRFFVACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------QRD------GDHGTQL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------HEHYDSAGAGT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HTLPS------------------------- ------------------------------------------------------------ --------------------RQI------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEDAT-------------------------------FGTVLASRA IKAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRQHS---------SLL---------------- -------RTIFI----SGE----------------------------------------- -----------TRVPM---YTVLEVY-------RVSD---------------MELVRV-- ------------LPSAGE---------------------EVNAA------CFHPSPGS-- ----GLVYGTK----------------QG-KVRFLQHHG--------------------- -------------------------------------------------------AVSTR WGE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------CS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >TaAMBRA1c ------------------------------------------------------------ ------------------------------------------------------------ -----M--------A-----------EN----------------------WV------EE A----------------------------------------------------------- ------------------------------------------------------------ ----------------------------SKN-ASAP----TSFSGSP----------PSC ---QTSSTRRS---------RQ--RNIFHLLSHREVS-PR-TKHQAKRHW---NKP-PTC GAGYS------------------------ELRYS-ATDAKHDLFSW-------------A ESQSLHRW----------------------------------SAKY-C------------ -------------PLMPPP----RSTIAAAFSSDGKTLASTHG----------------- -------------------------DHTVKIIDCQTGKCLKVLGGHRRTPWV-------- ----------------VRYHPLH-SDILASGSLDHEVRLWDANT--SDCIGSQDFQ-RPI ASIAFHARGEILAVASGHK-LFIWNYNR------------------------RGES---- ------------------------------------------------------------ S-APTIILRT--------RRSLRAVHFHPHGAPYLLTAE--------------------- ----VNNLD------------SADSQLTHATSTGYSNY---------------------- ------------------------------------------------------------ ------------------------------------PS---------------------- -----ALFFAN-------------------------------------------INSRG- Y-----------------------PHLES-----------NV----SSPC---------L IW--------------P---------------------------------------AFLR DDGS------LYIPRNDL-ASGS------------------------------------T NV-------QQS--SSSLAQNVLAS--------------------DAENQQ--------- -------------------------------SDQSVT-PM---------------DVCPG --EPSASS---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------D----------------------------------- -----------VQM----------------------PSTSNSL----------------- ---------------PLPAIAR-------------------------------------- ------------------------------------PS--GSAVDRMP------------ --------VNS-F-TT-SGLDVQMFLRNS-------EGGNHHHDL---------FSDSRS WEL-----PFLHG---------WLMAQSQ----------------------TGA------ ------------------------------------------------------------ -----------------------SSSI--------------------------------- -------------------------------------------PIPAGSTR--------- -------GSNRHYASRPHA-SA-------------------------------------- --SVP-----------------GVGNSLL------------GPQIDEAEARAASLGVGSE LA------------------------------TSL------------------------- ------------------FSAGAAEL---------PCTVKLRVWRHDIKNPCVALETKAC CLT---------------ISHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLVACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CL-------------------------- ------------------LP---------------------------------------- ----------------------QTE------GDQGNQL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVQYESTGAGT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPLPS------------------------- ------------------------------------------------------------ --------------------HGV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGEILTSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSIVM----DAE----------------------------------------- ----------TTGIPV---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPSPGG-- ----GLVYGTK----------------EG-KLRILQHNG--------------------- -------------------------------------------------------ADAAS MGL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----NCFI------------------------------------E-------------EN MLE-------VQ-------------RY--------------------------------- ------------------------------------------------------A----- --------------------------LE-------------------------------- ------------------------------------------------------------ ---------------------------------------------------G-------- ------------------------------------------------------------ --------------------- >TaAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------A-----------EN----------------------WV------EE G----------------------------------------------------------- ------------------------------------------------------------ ----------------------------SKN-TSAP----T----SP----------PSC ---QTSSTRRS---------RQ--RNIFHLLSHREVS-PR-TKHQAKRHW---NKP-PTC GAGYS------------------------ELRYS-ATDAKHDLFSW-------------A ESQSLHRW----------------------------------SAKY-C------------ -------------PLMPPP----RSTIAAAFSSDGKTLASTHG----------------- -------------------------DHTVKIIDCQTGKCLKVLGGHRRTPWV-------- ----------------VRYHPLH-SDILASGSLDHEVRLWDANT--SDCIGSQDFQ-RPI ASIAFHARGEILAVASGHK-LFIWNYNR------------------------RGES---- ------------------------------------------------------------ S-APTIILRT--------RRSLRAVHFHPHGAPYLLTAE--------------------- ----VNNLD------------SADSQLTHATSTGYSNY---------------------- ------------------------------------------------------------ ------------------------------------PS---------------------- -----ALFFAN-------------------------------------------INSRG- H-----------------------PHLES-----------NM----SSPC---------L IW--------------P---------------------------------------AFLR DDGS------LYIPRNDL-ASGS------------------------------------T NV-------QQS--SSSLAQNVLAS--------------------DAENQQ--------- -------------------------------SDQSVT-PM---------------DVCPG --EPSASS---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------D----------------------------------- -----------VQM----------------------PSTSNSL----------------- ---------------PLPAIAR-------------------------------------- ------------------------------------PS--GSAVDRMP------------ --------VNS-F-TT-SGLDVQMFLRNS-------EGGNHHHDL---------FSDSRS WEL-----PFLHG---------WLMAQSQ----------------------TGA------ ------------------------------------------------------------ -----------------------SSSI--------------------------------- -------------------------------------------PIPAGSTR--------- -------GSNRHYASRPHA-LA-------------------------------------- --SVP-----------------GVGNSLL------------GPQIDEAEARAASLGVGSE LA------------------------------TSL------------------------- ------------------FSAGAAEL---------PCTVKLRVWRHDIKNPCVALETKAC CLT---------------ISHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLVACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CL-------------------------- ------------------LP---------------------------------------- ----------------------QTE------GDQGSQL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVQYESTGAGT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPLPS------------------------- ------------------------------------------------------------ --------------------HGV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGEILTSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSIVM----DAE----------------------------------------- ----------TTGIPV---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPSPGG-- ----GLVYGTK----------------EG-KLRILQHNG--------------------- -------------------------------------------------------ADAAS MGL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----NCFI------------------------------------E-------------ES MLE-------VQ-------------RY--------------------------------- ------------------------------------------------------A----- --------------------------LE-------------------------------- ------------------------------------------------------------ ---------------------------------------------------G-------- ------------------------------------------------------------ --------------------- >TaAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------A-----------EN----------------------WV------EE G----------------------------------------------------------- ------------------------------------------------------------ ----------------------------SKN-TSAP----T----SP----------PSC ---QTSSTRRS---------RQ--RNIFHLLSHREVS-PR-TKHQAKRHW---NKP-PTC GAGYS------------------------ELRYS-ATDAKHDLFSW-------------A ESQSLHRW----------------------------------SAKY-C------------ -------------PLMPPP----RSTIAAAFSSDGKTLASTHG----------------- -------------------------DHTVKIIDCQTGKCLKVLGGHRRTPWV-------- ----------------VRYHPLH-SDILASGSLDHEVRLWDANT--SDCIGSQDFQ-RPI ASIAFHARGEILAVASGHK-LFIWNYNR------------------------RGES---- ------------------------------------------------------------ S-APTIILRT--------RRSLRAVHFHPHGAPYLLTAE--------------------- ----VNNLD------------SADSQLTHATSTGYSNY---------------------- ------------------------------------------------------------ ------------------------------------PS---------------------- -----ALFFAN-------------------------------------------INSRG- Y-----------------------PHLES-----------NM----SSPC---------L IW--------------P---------------------------------------AFLR DDGS------LYIPRNDL-ASGS------------------------------------T NV-------QQS--SSSLAQNVLSS--------------------DAENQQ--------- -------------------------------SDQSVT-PM---------------DVCPG --EPSASS---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------D----------------------------------- -----------VQM----------------------PSTSNSL----------------- ---------------PLPAIAR-------------------------------------- ------------------------------------PS--GSAVDRMP------------ --------VNS-F-TT-SGLDVQMFLRNS-------EGGNHHHDL---------FSDSRS WEL-----PFLHG---------WLMAQSQ----------------------TGA------ ------------------------------------------------------------ -----------------------SSSI--------------------------------- -------------------------------------------PIPAGSTR--------- -------GSNRHYASRPHA-LA-------------------------------------- --SVP-----------------GVGNSLL------------GPQIDEAEARAASLGVGSE LA------------------------------TSL------------------------- ------------------FSAGAAEL---------PCTVKLRVWRHDIKNPCVALETKAC CLT---------------ISHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLVACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CL-------------------------- ------------------LP---------------------------------------- ----------------------QTE------GDQGSQL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVQYESTGAGT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPLPS------------------------- ------------------------------------------------------------ --------------------HGV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGEILTSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSIVM----DAE----------------------------------------- ----------TTGIPV---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPSPGG-- ----GLVYGTK----------------EG-KLRILQHNG--------------------- -------------------------------------------------------ADAAS MGL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----NCFI------------------------------------E-------------EN MLE-------VQ-------------RY--------------------------------- ------------------------------------------------------A----- --------------------------LE-------------------------------- ------------------------------------------------------------ ---------------------------------------------------G-------- ------------------------------------------------------------ --------------------- >ZmAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------------------EPRVPCV--------------------------D GGGDG--LEL--------RAARRHRREGG------------------------------- ---------------------RIHVLDA----------------------------QILE P---------------------------QRQ-RSNPFRSLAAKDMKMP------F--IQT ---TVSKRANH---------FD--LNIFHLLTQREVL-PR-TKHHAKRIW---NNS-PKY DPHLI------------------------ELRFS-DADAKLGILSW-------------A ESLSLHRW----------------------------------SAKY-C------------ -------------PLLPPP----RSTIAAAFSPDGKSLASTHG----------------- -------------------------DHTVKIMDCHTGKCVKVLSGHRRTPWV-------- ----------------VRYHPLH-SDILASGSLDHEVRLWDANT--SDCIGSQDFH-RPI ASIAFHGRGEILAVASGHK-LYIWNYNK------------------------RDDA---- ------------------------------------------------------------ S-VPTIILRT--------RRSLRAVHFHPHGAPYLLTAE--------------------- ----VNNIE------------SADSPLTLARSSGYSNY---------------------- ------------------------------------------------------------ ------------------------------------PS---------------------- -----ALLVSN-------------------------------------------TNSRF- C-----------------------PLPES-----------NV----TSPC---------L LW--------------P---------------------------------------AYLR DDGI------LHVLGNA---SSS------------------------------------T IV-------QQR---SSLVQ-PSTS--------------------DTANLQ--------- -------------------------------LEQFAT-PM---------------DVCPG --EPTSFNN----------------------------------ISDAVT----------- -----------------------------VPT--------------------SN------ -----------------------AIEMHGA------------------------------ ----------------------GGQ----------------------------------- --SN-PRLQGSSSISNLERFSARDA----------------------------------- -----------LQV----------------------SSLSSIE----------------- ---------------PIPSTAG-------------------------------------- ------------------------------------SS-GSNSRRAMP------------ --------LNM---LLTGGLDVQMFQRNV-------GSGQQDHFL---------FGDSSN WEV-----PFVQG---------FLMTQNH----------------------TGL------ --HP-AL-VNNNVL-EDLSGAGTAGINN------------------------------ST RE---------SSHMHNFGRPGASSSI--------------------------------- -------------------------------------------PLTSGSSR--------- -------RPNRHYASR-------------------------------------------- --SVP-----------------GVGSLLLV-----------GPQIDEAEAHAASLGAGSE IT------------------------------ASM------------------------- -------------------LAPGTEL---------PCTVKLRIWRHDINEPCVPLAPEAC RLT---------------ISHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLVACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CL-------------------------- ------------------LP---------------------------------------- ----------------------QTE------GGRGSQL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVPYE--EAGS------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPLPS------------------------- ------------------------------------------------------------ --------------------HRV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEET-------------------------------FGDILASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSIVV----EGE----------------------------------------- -----------NGIPV---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPLPGG-- ----GLVYGTK----------------VGSKLFNKQKDP--------------------- -------------------------------------------------------EKDFS AGF--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ICVIR----------------------------------PR-------------EN IRS-------IS-------------NYIRTDNSQ-WAL---------------------- --SSALGTGNIGIQFTDWNRVLTSIISS-------------------YNLLKQAA----- --------------------------LQIFSAGSGAL-----------NICPVLQ----- ------------------------------------------------------------ --------------------------------------------------VG-------- LDV-----------------------------------------Q--------------- --------------------- >ZmAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------A-----------EC----------------------RI-------Q DW---------------------------------------------------------- ------------------------------------------------------------ ----------------------------KRA--STP----ESV--------------SR- ---HETSIPRT---------KQ--RNIFSLLAQRELS-PR-TKNQAKNLW---TKP-PRL DACPI------------------------ESKFW-GTYAQHDLLSW-------------A EAEFLHWW----------------------------------IPKY-C------------ -------------PLTPSS----KATIAAAFSTDGRVLASTHG----------------- -------------------------DHTVKIIDWQTGKCLNVLLGHHRTPWV-------- ----------------VRFHPQR-SDILASGSLDCEVRLWDAKT--SRCTAELVFY-RPV ASIAFHATGELLAVASGHK-LFLWDCNK------------------------RWET---- ------------------------------------------------------------ L-ELPIILET--------RRSLRAVQFHPHGAPYLLTGE--------------------- ----VHNLD------------SEDSTMTPALLSNYSFR---------------------- ------------------------------------------------------------ -----------------------------------DTP---------------------- -----LLGGSG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------VDNLIS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -EL-----QYMQN-------------FEQ----------------------VGA------ ------------------------------------------------------------ -----------------------SSSV--------------------------------- -------------------------------------------PVTTGSFD--------- -------GSRLHDTSGHHL-MT-------------------------------------- --SLP-----------------SVGRPLL------------GTHA--AEAPAISLSVGSE QT------------------------------TSL------------------------- -------------------LGGGTEL---------PCTVKLRIWRHEMKNPFITLGPEAC LLT---------------IPHAVL------------------------------------ -------------------------------------------CSRKTVTSTICTIWMY- -----------CEMGTHVSPCGRFLVACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------HSY------GGHGSQL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------HEHYDSTGAGT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---QAFPS------------------------- ------------------------------------------------------------ --------------------RQI------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEDAT-------------------------------FGTVLATRA IKAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRQHS---------SLL---------------- -------RTILI----NGE----------------------------------------- -----------TRVPV---YTVLEVLFMGLSKGRLGF---------------FGTMVH-- ------------HSLAGENV------------------HEVMVY------CYYRNLWS-- ----TEIISKT----------------ER-ANR--KHQI--------------------- -------------------------------------------------------SASNY S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >ZmAMBRA1c MWRKMA-------------------------TCIRKIASEEFGLSQGNRREVKDTWWWNE DVQKAIKEKKDCYKRLHHDKCAENIEKYRIAKKSAKRAVSRARGQAYDDLYQRLDTKQGE KDIYRM--------A-KIRERK-TRDVNQVKCIKDEANQLLVKSEEIKNRWKEYFNKLFN GGNERATIELDEPFDDNNRGFVRRIQEYEVKEALKRMKVGKAMGPDGIPIEVWRCLGDIA IVWLTKLFNTIFRANRMPDEWRRSTLVPIFKNKGDVQSCTNYRGIKLMSHTMKLWERVIE HRLRKMTSVTQNQFGFMPGRSTMEAIFLLRQ-LMERFR-EQKKDLHMV------FIDLEK ---AYDKVPRS---------VM--WNIFHLLTQREVS-PR-LKHHAKRMW---NES-PKY DPDSI------------------------ELR---SADAKLDIFSW-------------A ESQSLHSW----------------------------------SAKY-C------------ -------------PLLPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDCQTGKCLKVLTGHRRTPWV-------- ----------------VRYHPLH-SDILASGSLDHEVRLWDANT--SDCIGSQDFH-RPI ASIAFHGSGEILAVASGHK-LYIWNYNK------------------------RDGT---- ------------------------------------------------------------ S-VPAIILKT--------RRSLRAVHFHPRGAPYLLTAE--------------------- ----VNNIE------------SADSPLTLARSSGYLNY---------------------- ------------------------------------------------------------ ------------------------------------PS---------------------- -----ALLVTN-------------------------------------------TNSRF- C-----------------------TLPES-----------NV----VSPC---------L LW--------------P---------------------------------------AYLR DGGI------LHVLGND---SSS------------------------------------T IV-------QQR---SSLVQ-PSTS--------------------DTANVQ--------- -------------------------------LEQFAT-PM---------------DVCPG --EPTSSND----------------------------------IPDAVT----------- -----------------------------VPT--------------------SN------ -----------------------GNEMHGA------------------------------ ----------------------GGQ----------------------------------- --SN-SRLQGSSSTSNLERFSARDD----------------------------------- -----------LQV----------------------SSLSRTD----------------- ---------------PIPLTAG-------------------------------------- ------------------------------------PS-GSDLHRAMP------------ --------LNM---LLTGGLDVQMFLRNV-------GSGQQDHSL---------FGDSRN WEV-----PFLQG---------FLMAPNH----------------------AGL------ --HP-AL-VNNSVL-EDMSIAGTAGTNN-------------------------------- LK---------SPHMRNFGCPGASSSI--------------------------------- -------------------------------------------PLTTGSSR--------- -------GPNRRYASR-------------------------------------------- --SVP-----------------GVGNLLL------------GPQIDEAEAHAVSLGAGSE IT------------------------------ASM------------------------- -------------------LAPGTEL---------PCTVKLRIWRHGTNEPCVPLEPEAC CLT---------------ISHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLVACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CL-------------------------- ------------------LP---------------------------------------- ----------------------QTE------DDRGSQL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVSYE--GAGS------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPLPS------------------------- ------------------------------------------------------------ --------------------HRV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEAET-------------------------------FGDILASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSIVV----EGE----------------------------------------- -----------NGVPV---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPSPGG-- ----GLVYGTK----------------EG-KLRILQHNG--------------------- -------------------------------------------------------ADMTN MGV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----GCFI------------------------------------E-------------EN MVE-------IQ-------------RY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------C--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >ZmarAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------K-----------EK----------------------IS-------D D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------GKS-ATTS----TLYS------------CSQY VPGKDKMRSYA---------SV--RNVFQFLASREIN--R-AKRVPRSFE---AKSLPES KTDCV------------------------GVKYR-EVNVNRALISW-------------V ESESLKHL----------------------------------SAKY-C------------ -------------PLLPPP----RSTIAAAFSSDFKILASTHG----------------- -------------------------DHTVKIIDCLTGHCLKVLSGHRRTPWV-------- ----------------VRFHPVY-PEILASGSLDHEVRLWDANT--AYCIGFRDFY-RPI ASIAFHAHGHLLAVASGHK-LYIWNYNR------------------------R--E---- ------------------------------------------------------------ S-NPSVVLKT--------RRSLRAVHFHPHAAPFILTAE--------------------- ----VNNLD------------STDTALTLATTTGYLCY---------------------- ------------------------------------------------------------ -----------------------------------DPP---------------------- -----AVFFTN-------------------------------------------IQSTS- Y-----------------------MHGEG-----------NTPFISPGPL--SMKNHRET VWQNPHHETESVAIERP---------------------------------------EFSF TDQR------QAHLYSDN-QHG-------------------------------------- ---------------------IEIT--------------------SMESQQ--------- -------------------------------HDIEIT-RM---------------ERQPS --GTSNSLH----------------------------------LPDGEMGNS-------- ---------------------ILMDGAGPIDS--------------------GSF----- ---------------------TVMNTVEAT------------------------------ ----------------------EEQ-----------AGD--------------------- --TV-QRSSRNFHPTTAPSPFEIREM---------------------------------- -----------TQQLPI-----------------RP------------------------ -----------------DGTPH-------------------------------------- ------------------------------------------------------------ ---------NF-S-GSIRSLDSQMLLRNV-------DNMQNCQILP--------SGDQPG WEL-----PFLQG---------WLMGQTH----------------------AGL------ --NA-IF-PSNDSL-LENPSMVQG------------------------------------ ---------------------IISDAL--------------------------------- -------------------------------------------RSGLQPA---------- ------RGSIIHRHSYSHVLTP-------------------------------------- --SAS-----------------AEGMVHM------------DVQNDDLVRQSAHFNIASE LA------------------------------ASV------------------------- ------------------SSDSSTEL---------PCTVKLRIWPYDVQRPSALLDPSTC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CI-------------------------- ------------------LP---------------------------------------- ----------------------HVE------LDPGSNS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QSHHDAMETGT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISG------------------------- ------------------------------------------------------------ --------------------HRF------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGLVLVSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILVAYGRRHS---------SLL---------------- -------KSFVT----DGE----------------------------------------- -----------TRVHI---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPSPGY-- ----GLVYGTK----------------EG-RLRILQFLS--------------------- -------------------------------------------------------QSEIS STR--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---QNRRD------------------------------------S-------------E- ----------FQ-------------TN--------------------------------- ------------------------------------------------------AP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >AcoeAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----MSFCEKEGSTRS---------SS----------------------PV-------D D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------GNF-PCTS----SQPDGISS------------ ---QAPAGARR---------SG--ANVYRLLAKREIC-PR-AKHSSKKLW---GEI-SDC N------------------------------NIREITDAKHGLISW-------------V ESESLRHL----------------------------------SAKY-C------------ -------------PLVPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDCQTGSCLKVLSGHRRTPWV-------- ----------------VRFHPVH-PEILASGSLDHEVRLWDANT--AECIGSRDFY-RPI ASIAFHAQGEVLAVASGHK-LYIWHYNR------------------------KEET---- ------------------------------------------------------------ P-LPAIVLKT--------RRSLRAVHFHPHAAPFLLTAE--------------------- ----VNDLD------------SPDSPMTLATSPGYLHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVFFAN-------------------------------------------VHSGV- R-----------------------PNMEP-----------RATPM-PFPF---------L FW--------------P---------------------------------------TFAR DGG-------PSFQHAFM-AASS------------------------------------S ---------SQTVRPSAPVQ-LQTD--------------------PSIGSQ--------- -------------------------------LDYLVS-PM---------------DIAPA --IPSTSFP----------------------------------VPESV-NNS-------- ---------------------FLSETENAVSD--------------------SA------ -----------------------MDIMDTT------------------------------ ----------------------EGQ----------------------------------- --PI-GRDYHSRSPML-DTPDGVSN----------------------------------- -----------TPPL---------------------SFQPSGV----------------- -----------------GRMPS-------------------------------------- ------------------------------------RHVRSGVEATPG------------ --------IYL-S-TFSGNPGLQMLLRGG-------ESSQLHQFFP--------FGDPMF WEL-----PFLQG---------WLMGQSQ----------------------AGL------ --HP-ML-SLNDAL-HERAPGFRGAGSD-----------------------------ILA SD---------F-ASRSMDTTLASSIM--------------------------------- -------------------------------------------TNGVNQSR--------- ---MAGRSGLRYRSSRTRTM---------------------------------------- --AGP-----------------GEGAGFI------------NIMHDESDPQPVIGRTESE LA------------------------------TSL------------------------- ------------------AAAAAAEL---------PCTVKLRVWPHDIKDPCALLDAEKC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CM-------------------------- ------------------LP---------------------------------------- ----------------------HME------AEPGLQS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QVHHDVTGAST------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAT-------------------------------FGLVLASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSIVI----DGE----------------------------------------- -----------TTVPI---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPLVGG-- ----GLVYGTK----------------EG-KLRILQYDG--------------------- -------------------------------------------------------SHGTN CAG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---ANLNL------------------------------------E-------------EN MLE-------VN-------------GI--------------------------------- ------------------------------------------------------Q----- --------------------------RQ----------------------VMIG------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >DcaAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M---------------------------------ILI--------YC-------- ------------------------------------------------------CG---- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GC--SNVFRLLARREIS-PR-TKDSSRNLW---RED-SKS NVNSA------------------------VLRGEAARDVRRSLISW-------------V EAESLRHF----------------------------------TAKY-C------------ -------------PLLPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDCQTGRCLKVLSGHRRTPWV-------- ----------------VRFHPLC-PDILASGSLDHEVRLWNAKT--AECIGSRDFY-RPI ASIAFHAQGEFLAVASGHK-LYIWHYSG------------------------RVET---- ------------------------------------------------------------ V-SPSIILKT--------RRSLRAVHFHPHAAPFLLTAE--------------------- ----VNELE------------SSDSTVTLATCPNYLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----TVYLAD-------------------------------------------AHPDN- Q-----------------------SRQVS-----------ELPLM-SLPF---------L LW--------------P---------------------------------------SIGR GDGR------IPLQQTDA-DVSS------------------------------------T ST-------TQRAESSGSVR-LLTY--------------------STPSGQ--------- -------------------------------YELLLS-PI---------------E---- ---PGSSP-----------------------------------VPQEPEANA-------- ---------------------LIVEMENGSTN--------------------PT------ -----------------------VDAMET------------------------------- ----------------------DVQ----------------------------------- --PE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RVNQIFP--------LGDPTS WEV-----PFLQG---------WFIGQSQ----------------------AGQ------ --QT-MH-PFNVVA-AENVSNS-------------------------------------- -------------TRMENHGSTTPTAL--------------------------------- -------------------------------------------PSGSAESR--------- ---LNLRSGSHHQYSQPYM-SS-------------------------------------- --TAS-----------------GSG----------------TLTRDESESQHFVERIQSE IA------------------------------TSL------------------------- ------------------AAAAAAEL---------PCTVKLRIWPHNVKEPCRLLDAERC RLI---------------IPHAVL------------------------------------ -------------------------------------------C---------------- ----------------------RFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------NVE------ADAGFPGQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QVHPDVMGVST------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------QEV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAT-------------------------------FGLVLASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HLLLAYGRRHS---------SLL---------------- -------KSVVI----DGE----------------------------------------- -----------TTVPV---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPSVGG-- ----GLVYGTK----------------EG-KLRIFQYNV--------------------- -------------------------------------------------------SSGLN YSG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---ICS-S------------------------------------D-------------ED MIE-------VI-------------RQ-------R------------------------- ------------------------------------------------------S-FI-- ------------------------I-VN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------STHR----------- --------------------- >HaAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------K-T---------TP----------------------AS------LH D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------LSS-SSTS------------------------ ------SPPHR---------NS--RNVFQMLTRREIA-PRIKKHVSRRHR---GRN-FDL NHRRYV-----------------------KPNSESARDSRRELLSW-------------V ETESLGWL----------------------------------SAKY-C------------ -------------SLMPSP----RSTIAAAFSPDGKILASTHG----------------- -------------------------DHTVKIIDCQTGKCLKVLSGHRRTPWV-------- ----------------VRFNPLH-PEILASGSLDHEVRLWNANT--SECIRSRDFY-RPI ASIAFHSEGELLAVAAGHK-LYLWQYNS------------------------RGET---- ------------------------------------------------------------ S-SPAIILRT--------RRSLRAVHFHPHAAPLLLTAE--------------------- ----VNDLD------------SSDSTMAPATSQAYMHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVYMGN-------------------------------------------MHRID- R-----------------------LSLAA-----------ELPLV-PLQL---------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------MQTD----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GAGASN---------------------------- --------------------------MNIS------------------------------ ----------------------GVE----------------------------------- --DM-GSS---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------QLGRDSGLDP--------LREHVR WEL-----PFMQG---------WLMGQSQ--------------------NQAGP------ --PP-TF-PLGGSP-HRYTV---------------------------------------- -----------------------ATEP--------------------------------- -------------------------------------------PFNI------------- ------------------------------------------------------------ ------------------------NLGQT------------NEATDGVDSIPMMNIIQSQ IS------------------------------ASL------------------------- ------------------TATAAAEL---------PCTVKLRIWSHDIKNPCALLKPESC RLV---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRYLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------QFE------ADSGIST---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QLHQDVSRAGT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------RHV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLEEAT-------------------------------FGSVLISRP IRAAH--CLTSVQ-----------------FSPSSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------RSIDI----NGD----------------------------------------- -----------TSLSI---YTVLEVY-------RVSD---------------MELVSV-- ------------LPSAED---------------------EVNVA------CFHPFSGG-- ----GIVYGTKVSLESFSLTVLAGQILPD-LITILKHKW--------------------- -------------------------------------------------------SMLNN STG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---ACT------------------------------------------------------ -------------------------SY--------------------------------- ------------------------------------------------------P----- --------------------------NR----------------------CC-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >HaAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------D-A---------TS----------------------CI-------D D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------LNT-LSSS------------------------ ---SLPSQIHQ---------ND--RNVLHLLARREIA-PRTAKCLPKRQR---GEV-SNH KHQSSV-----------------------KPESERVRNSKSELLSW-------------V EAESLRCL----------------------------------SAKY-C------------ -------------PLEPSP----RSTIAAAFSADGKILASTHG----------------- -------------------------DHTVKIINCHTGKCEKVLSGHRRTPWV-------- ----------------VRFHPLH-PEILASGSLDHEVRLWNANT--SECIGSRDFY-RPI ASIAFHAEGELLAVAAGHK-LYFWHYNN------------------------RGEG---- ------------------------------------------------------------ S-APAIVLKT--------RRSLRAVHFHPHSAPFLLTAE--------------------- ----VNDLD------------SSDSTMAHATSLGYLHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----TVYMGN-------------------------------------------MHSID- R-----------------------LSLAA-----------ELPLM-HVPL---------F FS--------------H---------------------------------------PHPN TDPR------PQLQTVNR------------------------------------------ -------------PSESSDR-LQVL--------------------ANATEL--------- -------------------------------YEQMMA-SV-------------------- --PPSNPID------V-------------------------------------------- ---------------------------TGATN---------------------------- --------------------------MDIP------------------------------ ------------------------------------------------------------ -EPM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------LSQMGG WEL-----PFMQG---------WLVGQSQ---------------------QAGT------ -----SL-P--------------------------------------------------- -----------------LELAEGSPAM--------------------------------- -------------------------------------------PYGSNPVD--------- ----PERQRVQDLSSNGASISA-------------------------------------- --SQH-----------------RQNAIV-------------TETNGGNDSFPIISRIQSQ LS------------------------------ASL------------------------- ------------------TATAAAEL---------PCTVKLRIWPHDFENPCASLKAERC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRYLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------QFE------ADPGLPT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QLHQE--RAST------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------RQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAT-------------------------------FGSVLISRP IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------KSIVI----NGD----------------------------------------- -----------TSLSI---YTVLEVY-------RVSD---------------MELVSV-- ------------LPSAED---------------------EVNVA------CFHPLAGG-- ----GLVYGTK----------------EG-KLRILQYDG--------------------- -------------------------------------------------------AHTTR ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PDHFS------------------------------------EA------------QA AVE-------VQ-------------AY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------C--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >SlAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------R-G---------SL----------------------WP-------E N----------------------------------------------------------- ------------------------------------------------------------ ----------------------------SSS-DSST----SNPIHVPPPPPPPGWNSPAL -PIEQNPNCKN---------RC--GNVFQLLTKREVS-PR-AKRSSKKLW---DEN-SKY CAHSYE-----------------------KLKSQVARDPRRGLISW-------------V EAESLRHF----------------------------------SAKY-C------------ -------------PLLPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDCQSGKCLKVLSGHRRTPWV-------- ----------------VRFHPLY-SEIVASGSLDHEVRLWDAKT--AECIGSRDFY-RPI ASIAFHAQGEVLAVASGHK-LYMWHYNR------------------------RGEA---- ------------------------------------------------------------ S-SPAIILKT--------RRSLRAVHFHPHGAPYLLTAE--------------------- ----VNDLD------------SSDPLMTFTTSLGNLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----TVYLTD-------------------------------------------AHSTY- R-----------------------SASAN-----------ELPIM-SLPF---------M IW--------------P---------------------------------------SIAR GDPR------MPLQQSNA-DMGS------------------------------------D ST-------QNRADTSASVR-LLTY--------------------STPSGQ--------- -------------------------------YELLLS-PV---------------E---- ---PTLSPA------------------------------------QEAQTSS-------- ---------------------SVRDTENA-SN--------------------PV------ -----------------------GDPMET------------------------------- ----------------------DAP----------------------------------- --TE-ERN---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------NQFFP--------FSDPAY WDL-----PFLQG---------WLIGQSQ----------------------AGR------ --QA-IH-SEHSGA-TNIVS---------------------------------------- -------------AYGEVEHRPAVPSI--------------------------------- -------------------------------------------ISNGNHPR--------- ----SGRSGSRHRSSRSRVIPV-------------------------------------- --AGS-----------------GDSAVPI------------NIAHNESDSQALMSRFQSE IA------------------------------TSL------------------------- ------------------TAAASSEL---------PCTVKLRVWPYDIKVPCAPLDAEKC RLI---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CI-------------------------- ------------------SH---------------------------------------- ----------------------GME------ADPGFHG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QFRHD---AAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPIAA------------------------- ------------------------------------------------------------ --------------------HPV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAN-------------------------------FGRVLASRL IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HLLLAYGRRHG---------SLL---------------- -------KSIVI----DGD----------------------------------------- -----------TTLPV---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPLVGG-- ----GLVYGTK----------------EG-KLRILQFDK--------------------- -------------------------------------------------------SNGLD STV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---SCS-P------------------------------------D-------------ED MLE-------VP-------------TY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------G--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >SlAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------R-S---------SM----------------------SP-------D N--------L-------------------------------------------------- ------------------------------------------------------------ ----------------------------SSA-PSTS----RSS--------------PPS ---AASQNVNC---------KH--SNVFQLLTRREVA-PR-TKRASRKFW---GEN-TKC TLDSY------------------------GLKRGVGSDARQGLISW-------------V EAESLQHL----------------------------------SAKY-C------------ -------------SLLPPP----RSTIAAAFSPDGRTLASTHG----------------- -------------------------DHTVKIIDCQTGKCLKVMSGHRRTPWV-------- ----------------VRFHPLY-PEILASGSLDHEVRLWDAKT--AECIGSRDFY-RPI ASIAFHAQGEVLAVASGHK-LYIWHYNR------------------------RGEA---- ------------------------------------------------------------ S-SPSIILKT--------RRSLRAVHFHPHGAPFLLTAE--------------------- ----VNDLD------------SSDSSMTRATSP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AN-----------ELPIM-SLPF---------L IW--------------P---------------------------------------SIAR GDPR------IPMQQSDI-DVGS------------------------------------D NI-------QQRSDTLSSVR-LLTY--------------------STPSVQ--------- -------------------------------YELLLS-PI---------------E---- ---QSASPT------------------------------------QEAHTSS-------- ---------------------SVRENETG-TQ--------------------LL------ -----------------------VDPMET------------------------------- ----------------------DGQ----------------------------------- --PE-ERN---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------NQFFP--------FSDPAY WEL-----PFLQG---------WLIGRSQ----------------------AVQ------ --QT-TR-SDLGGA-TINPS---------------------------------------- -------------TYGELENPSAVPLV--------------------------------- -------------------------------------------ISSNSHPR--------- ----SGRSGSRHRSSRSRMIPV-------------------------------------- --AGA-----------------GDGAAPV------------NVMHDESDSQISIGRIQSE IA------------------------------TSL------------------------- ------------------AAAAAAEL---------PCTVKLRIWPYDIKVPCAALDAERC HLI---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CI-------------------------- ------------------LP---------------------------------------- ----------------------NLD------SDPGFHG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------HLHHDTMTAST------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPVAA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------M-------------- ---------------------------------------------------FGSVLAARA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HLLLAYGRRHS---------SLL---------------- -------KSVVI----DGD----------------------------------------- -----------TTIPI---YTILEVY-------RVSD---------------MELVRV-- ------------LPSTED---------------------EVNVA------CFHPSVGG-- ----GLVYGTK----------------EG-KLRILQYDN--------------------- -------------------------------------------------------SNSLG RTI--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PCS-P------------------------------------V-------------EN MLE-------VP-------------TY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------G--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >StAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------R-G---------SL----------------------WP-------E N----------------------------------------------------------- ------------------------------------------------------------ ----------------------------SSS-DSST----SNPIHVPLPPPPPGWNSPSL -PIEQNPNCKN---------RC--GNVFQLLTRREVS-PR-AKRSSKKLW---DEN-SKY CAHSYE-----------------------KLKSQVARDPRRGLISW-------------V EAESLRHF----------------------------------SAKY-C------------ -------------PLLPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDCQSGKCLKVLSGHRRTPWV-------- ----------------VRFHPLH-SEILASGSLDHEVRLWDAKT--AECIGSRDFY-RPI ASIAFHAQGEVLAVASGHK-LYMWHYNR------------------------REEA---- ------------------------------------------------------------ S-SPAIILKT--------RRSLRAVHFHPHGAPYLLTAE--------------------- ----VNDLD------------SSDPLMTFATSLGNLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----TVYLTD-------------------------------------------AHSTY- R-----------------------SASAN-----------ELPIM-SLPI---------M IW--------------P---------------------------------------SIAR GDPR------MPLQQSNV-DMGS------------------------------------D ST-------QNRADTSASVR-LLTY--------------------STPSGQ--------- -------------------------------YELLLS-PV---------------E---- ---PTLSPA------------------------------------QEAQTSS-------- ---------------------SVRDTENA-SN--------------------PV------ -----------------------VDPMET------------------------------- ----------------------DVP----------------------------------- --TE-ERN---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------NQFFP--------FSDPAY WDL-----PFLQG---------WLIGQSQ----------------------AGR------ --RS-IH-SEHSGA-TNIVS---------------------------------------- -------------AYGEVEHPPAVPSI--------------------------------- -------------------------------------------ISNSNHPR--------- ----SGRSGSRHRSSRSRAIPV-------------------------------------- --AGS-----------------GDSAVPI------------NIAHNESDSQAFMSRFQSE IA------------------------------TSL------------------------- ------------------TAAAASEL---------PCTVKLRVWPYDIKVPCALLDAEKC RLV---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CI-------------------------- ------------------SP---------------------------------------- ----------------------SME------ADPGFHG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QFRHD---AAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPIAA------------------------- ------------------------------------------------------------ --------------------HPV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAN-------------------------------FGRVLASRL IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HLLLAYGRRHG---------SLL---------------- -------KSIVI----DGD----------------------------------------- -----------TTLPV---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPLVGG-- ----GLVYGTK----------------EG-KLRILQFDK--------------------- -------------------------------------------------------SNGLD CTV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---SCS-P------------------------------------D-------------ED MLE-------VP-------------TY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------G--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >AthAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-E---------SI----------------------WL-------N D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------QSS-PRSM----IP---------------SAK ---PVANVHRQ---------RC--RSVFKLLVQREIS-PN-TKFVPRKRW---GES-RCD -ADSSC-----------------------GTTSEPVREQGLNLISW-------------V EAESLQHL----------------------------------SAKY-C------------ -------------PLVPPP----RSTIAAAFSSDGRTLASTHG----------------- -------------------------DHTVKIIDCETGKCLKILTGHRRTPWV-------- ----------------VRFHPRH-SEIVASGSLDHEVRLWNAKT--GECIRTHDFY-RPI ASIAFHAGGELLAVASGHK-LHIWHYNK------------------------GGDD---- ------------------------------------------------------------ S-APAIVLKT--------RRSLRAVHFHPHGVPLLLTAE--------------------- ----VTDID------------SSDSAMTRSTSPGYLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AIFFTN-------------------------------------------TQSGS- R-----------------------TSLAA-----------ELPLV-PLPY---------L LL--------------P---------------------------------------SYSA DDPR------I--LYSSG-TTGP------------------------------------- --------------RNAQTR-FQSN--------------------QSSVEH--------- -------------------------------GSRTIS-P-------------------SP --LPMATSADLSGSY---------------------------HVPDNSASNT-------- ---------------------FATQAGARNST--------------------TA------ -----------------------VDAMDVD------------------------------ ----------------------EAQ----------------------------------- --PV-GRN---------------------------------------------------- ------------------------------------------------------------ ------------------RVPS-------------------------------------- ------------------------------------QVSSQP------------------ --------------------------DLL-------EFGQLQQLFH--------FRDRGS WEL-----PFLQG---------WLMAQSQ----------------------AGA------ --NSVAL-PTGSSG-HVNSTPYMGSS--------------------------------SA SH---------S-STASLEAGVASLEI--------------------------------- -------------------------------------------PGGVNLYG--------- ---VSARGDSRDRILQSRF-AG-------------------------------------- --SGL-----------------AEGRSSR------------NTQHEGADAQPVVNRIPSE LA------------------------------SSI------------------------- ---------------------AAAEL---------PCTVKLRVWSHDIKDPCSILKSDKC RLT---------------IHHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRYLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------IP---------------------------------------- ----------------------HAE------TDPSLQT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LVQQD-SGLAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPVTA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRVY-------- --------------SLEKES-------------------------------FGSVLVSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------KSIVS----DGE----------------------------------------- -----------TTSHF---FTVLEIY-------RVSD---------------MELVRV-- ------------LPSSED---------------------EVNVA------CFHPSPGG-- ----GLVYGTK----------------EG-KLRIFRYNT--------------------- -------------------------------------------------------AAASN LTA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PNSSP------------------------------------D-------------EN LAE-------VE-------------LL--------------------------------- ------------------------------------------------------TR---- --------------------------------------------------CRPMR----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >AthAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-Q---------SI----------------------CS-------S SQ-DQ------------------------------------------------------- ------------------------------------------------------------ ----------------------------SSS-PRSL----IT---------------PRK ---SATKFHRR---------RG--RSVFNMLVQREMS-PK-AKFVPRKRW---GKS-RWY -TDSSC-----------------------GTNNESMKETGQSLTSW-------------V EAESLQHL----------------------------------SAKY-C------------ -------------PLGAPP----RSTIAAAFSTDGRTLASTHG----------------- -------------------------DHTVKIIDCETGNCLKVLTGHRRTPWVVNNSISDS EMNFAHTFGICSVGWLVRFHPHH-SEIVASGSLDLEVRLWNTTT--SECIRSHLFY-RPI ASIAFHAEGELLAVASGHK-LHMWHYNR------------------------RGEG---- ------------------------------------------------------------ S-SPTVVLKT--------RRSLRAVHFHPHGAPLLLTAEW-------------------- ---QVNEID------------SLDSSMSRATSMGYLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AILFTS-------------------------------------------TESN-- Q-----------------------TSLAA-----------E------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------N--------- -------------------------------ENRTSS---------------------PP --LPLATSSGPSGPN---------------------------SVPGNSPSNI-------- ---------------------FLTRAGDRTS---------------------PA------ -----------------------VDGMDVD------------------------------ ----------------------EAQ----------------------------------- --PV-GRN---------------------------------------------------- ------------------------------------------------------------ ------------------GIPS-------------------------------------- ------------------------------------QVSNRS------------------ --------------------------DFP-------ELGQIRQLFH--------FRDRVS WEL-----PFLQG---------WLMAQGH----------------------GVA------ --NPVVT-PTGSSN-HGISAP--------------------------------------- -----------S-STASLEAAVALLEI--------------------------------- -------------------------------------------PSGVNLHA--------- ---VSRRGGAQEQTSQPQF-SR-------------------------------------- --TGL-----------------PEGVSSR------------NTQH-GSDAQPVVNRVQSE LA------------------------------TSIAAS---------------------- -----------------AAAAAAAEL---------PCTVKLRMWSHDIKDPYAQLKSDRC LFT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHYSPCGRYLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------FP---------------------------------------- ----------------------HGE------IDPGLQT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QAQQD-SGLAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPVTA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLQKES-------------------------------FGSVLVSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------RSIVS----DGE----------------------------------------- -----------TTSHF---FTVLEIY-------RVSD---------------MELVRV-- ------------LPSSED---------------------EVNVA------CFHPSPGG-- ----GLVYGTK----------------EG-KLRIFQYNT--------------------- -------------------------------------------------------AATSN FTG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PNT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >BrAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-Q---------PT----------------------CS------PQ R----------------------------------------------------------- ------------------------------------------------------------ ----------------------------QSS-PRSM----IP---------------PRK ---SVASFHRR---------RG--RSVLSMLLQREIS-PK-ARFVPRKHW---SKN---- -------------------------------RSYTMKQTGQSLLSW-------------A EAESLQHL----------------------------------SAKY-C------------ -------------SFGVSP----KSTIAAAFSSDGKTLASTHG----------------- -------------------------DHTVKIIDFQTGNCLRVLTGHHRTPWV-------- ----------------VRFHPRD-SEIVASGSLDQNVRVWNVTT--SECIKSHDFR-KPI ASIAFHAEGELLAVASGHK-LHMWHYNG------------------------SGEE---- ------------------------------------------------------------ S-TPVVVLKT--------KRSLRAVHFHPHGAPFLMTAE--------------------- ----VSEID------------PLDSSMSIATSVGHLRY---------------------- ------------------------------------------------------------ -----------------------------------PPPP--------------------- -----AIVFTR-------------------------------------------RESSQ- ----------------------------------------DLPLV-PTPQ---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TV-GRN---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RSDRP------------------ ------------------------------------ELRNIR------------------ --------RLIQG---------WFLPEGH------------------------------- ------------------------------------------------------------ -------------------------SL--------------------------------- -------------------------------------------EGGVSFP---------- ------------------------------------------------------------ -------------------------------------------------VQPLANRVQPE FA------------------------------TPL------------------------- -------------------SAAATEL---------PCTIKIKVWQHDVSDPFALMKSDTC LLT---------------IPHVVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRYLATCVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------VP---------------------------------------- ----------------------HAE------IDPGLQT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LAQQD-SGLAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTQ---HPLTA------------------------- ------------------------------------------------------------ --------------------HPV------------------------------------- ---------------------------------------------IYELRVY-------- --------------SLQKES-------------------------------FGSVLVSRE IRAAN--CLTSIQ-----------------FSPTSE------------------------ ---------------------HIMLAYGRRHA---------SLL---------------- -------NSIVT----EDE----------------------------------------- -----------ATSRF---FRVLEIY-------RVSD---------------MELVRV-- ------------LPSSED---------------------EVNVA------CFHPSPGC-- ----GLVYGTK----------------EG-SLRIFQYNT--------------------- -------------------------------------------------------GATSN FSG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PNTYP------------------------------------E-------------EN LSE-------VA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >BrAMBRA1c ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-E---------PM----------------------WS-------H D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------QPS-PRSP----IP---------------SPS ---PVANSHRQ---------RC--RSVFKLLVQREIS-PK-TKFVPRKRL---GAN-RCG -ADSSC-----------------------GTSKQPVSELGHNLISW-------------V EAESLHHL----------------------------------SAEY-C------------ -------------PLVPPP----RSTIAAAFSSDGTTLASTHG----------------- -------------------------DHTVKIIDCETGKCLKVLSGHRRTPWV-------- ----------------VRFHPRH-SEIVASGSLDHEVRLWNAKT--SECIRSHDFY-KPI ASIAFHAGGDLLAVASGHK-LHIWDYNK------------------------RGED---- ------------------------------------------------------------ S-SPAIVLKT--------RRSLRAVHFHPHGVPLLLTAE--------------------- ----VTDID------------SSDSAMSRATSPGYLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AIFFTN-------------------------------------------TQSGG- R-----------------------TSMAA-----------ELPLV-PLPY---------L VL--------------P---------------------------------------SYSA DDPR------S--QQPAG-TTGP------------------------------------- --------------RNAQSR-FQSN--------------------QSS------------ --------------------------------GRTMS-P-------------------PT --LPLAMSGD-------------------------------------------------- ---------------------LAAQAGGRTST--------------------TA------ -----------------------VDAMDID------------------------------ ----------------------EAQ----------------------------------- --PI-GRN---------------------------------------------------- ------------------------------------------------------------ ------------------RIPS-------------------------------------- ------------------------------------QVLRQS------------------ -----------------------------------------EQLVH--------LRDRVS WEV-----PFLQG---------WLMAQSQ----------------------AGA------ --NSGVL-STGSSG-QASSTPHIGS----------------------------------- -------------STASLEAAVASLEI--------------------------------- -------------------------------------------PGGVNLYG--------- ---ASARGDSRDRVSQSRF-AG-------------------------------------- --SGL-----------------A------------------TQQHQGTDAQPVVNRIPSE LA------------------------------SSI------------------------- ---------------------AAAEL---------PCTVKLRVWAHDIKDPCAILKSDKC RLT---------------IHHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRYLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------HGE------TDPGLQT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LVQQD-SGLAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPVTA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRVY-------- --------------SLEKET-------------------------------FGSVLVSRA IRAAH--CLTSIQ-----------------FSPNSE------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------KSIVS----DGE----------------------------------------- -----------TTSHF---FTVLEIY-------RVSD---------------MELVRI-- ------------LPSSED---------------------EVNVA------CFHPSPGG-- ----GLVYGTK----------------EG-KLRIFRYNT--------------------- -------------------------------------------------------AVASN LTA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PNSSP------------------------------------E-------------KN LTE-------VQ-------------TY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------C--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >BrAMBRA1a MNFE-------------------------------------------------------- ------------------------------------------------------------ -----M--------M-E---------SI----------------------WS-------H D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------QPP-PPPPL---VP---------------SPK ---PVA---RQ---------RS--RSVFRLLVQREIS-PK-TKSVPRKRW---GVR-RCD TADSPC-----------------------GTSSETVSEQRHNLISW-------------V EAESLQHL----------------------------------SADY-C------------ -------------PLVPPP----RSTIAAAFSSDGRTLASTHG----------------- -------------------------DHTVKIIDCETGKCLKVLSGHRRTPWV-------- ----------------VRFHPRH-SEIVASGSLDHEVRLWNAIT--SECIRSHDFY-RPI ASIAFHAEGDILAVASGHK-LHIWHYNK------------------------TGED---- ------------------------------------------------------------ A-TPAIVLKT--------RRSLRAVHFHPHGVPLLLTAE--------------------- ----VTDID------------SSDSAMTRATSPGYLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AIFFTN-------------------------------------------TQSGGS H-----------------------TSMAA-----------ELPLV-PLPY---------L LL--------------P---------------------------------------SYSP DDPR------I--QYSTA-ATGP------------------------------------- --------------RSAQSR-FQSN--------------------QSSVEQG-------- -------------------------------GGRTMSTP-------------------PP --LPLAISGDL--------------------------------VPENS------------ ------------------------QARARTST--------------------TA------ -----------------------VDAMDID------------------------------ ----------------------EAQ----------------------------------- --PVGGGN---------------------------------------------------- ------------------------------------------------------------ ------------------RIPR-------------------------------------- ------------------------------------QVSSQS------------------ --------------------------DLL-------EFGQFQQLFH--------SRDRVS WEV-----PFLQG---------WLMAQSQ----------------------AG------- -----VL-PTGSSG---TAPPHTGSS--------------------------------SA SH---------T-STASLEAAVASLEI--------------------------------- -------------------------------------------PGGVNLYG--------- ---VSARD-------RTRF-SG-------------------------------------- --SGL-----------------AGGLASRN-----------AQQEAGADAQPVVNRLPSE LA------------------------------SSI------------------------- ---------------------AAAEL---------PCTVKLRVWAHDIKDPCAILRSDKC RLT---------------IHHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRYLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------IP---------------------------------------- ----------------------HAE------ADPGLQT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LVQQD-SGLAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPVTA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRVY-------- --------------SLEKET-------------------------------FGSVLVSRA IRAAH--CLTSIQ-----------------FSPNSE------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------KSIVS----DGE----------------------------------------- -----------TTSHF---FTVLEIY-------RVAD---------------MELVRI-- ------------LPSSED---------------------EVNVA------CFHPSPGG-- ----GLVYGTK----------------EG-KLRIFRYNT--------------------- -------------------------------------------------------AAASN LTA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PNSSP------------------------------------E-------------EN LAE-------VQ-------------TY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------C--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >CcAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-G---------LP----------------------WP-------H D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------QNS-LRSQ------------------------ ----PSNHLRR---------RA--RNVSRLLAHREIS-PK-TKYVPKRQW---VDA-SKL KTC--------------------------GPSDSSVRDAKRGLVSW-------------V EAESLRHL----------------------------------SAKY-C------------ -------------PLVPPP----RSTIAAAFSPDGRTLASTHG----------------- -------------------------DHTVKIIDCQTGNCLKVLSGHRRTPWV-------- ----------------VRFHPLR-SEILASGSLDHEVRLWDANT--SECIGSCDFY-RPI ASIAFHAEGELLAVASGHK-LYIWPYNN------------------------KEEA---- ------------------------------------------------------------ S-SPIIVLKT--------RRSLRAVHFHPHAAPFVLTAE--------------------- ----VNDLD------------SSDSSMTRATSPGYLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVFVAN-------------------------------------------AQSGD- H-----------------------VSLAA-----------ELPLMSSLPF---------L IV--------------P---------------------------------------SVSI DDSR------IDLQHASR-RASS------------------------------------S NM-------Q--IEPSASLQ-LQSD--------------------SNVE----------- -------------------------------QDGTVP-SM---------------ETFPV --IPP--------------------------------------GREGSVNDS-------- ---------------------FPNGIESGVSD--------------------YA------ -----------------------VDAMDTD------------------------------ ----------------------EMQ----------------------------------- --PV-GVSGQGNSMNLDTL----------------------------------------- ----------------------------------------GGV----------------- ----------------MRGIPS-------------------------------------- ------------------------------------HISSQP------------------ --------------------------AVT-------EFGQLQHLLP--------IRDRTF WEL-----PFLQG---------WLMGQSQ----------------------AGV------ --PP-ML-PLGGGN-RDHSAQHMGSS--------------------------------LM SH---------Q-SPYSVNAPVASLAV--------------------------------- -------------------------------------------PGSIGLSG--------- ---APGRSG-QHHIPHSRF-SE-------------------------------------- --SES-----------------REGAASS------------NILQDSTDTQPIVSRIQSE LA------------------------------TSL------------------------- ------------------AAAAAAEL---------PCTVKLRVWSHDIKNPCAALTAERC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRYLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CM-------------------------- ------------------LP---------------------------------------- ----------------------YTE------TDPGLQT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LVHQE-PGAST------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEST-------------------------------FGSVLVSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------KSIVI----DGE----------------------------------------- -----------TTSPI---YTVLEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPFAGG-- ----GLVYGTK----------------EG-KLRILQYDG--------------------- -------------------------------------------------------VHGAN CSG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PNYFT------------------------------------A-------------EN LTE-------VQ-------------TY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------C--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >CcAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------R-R---------SI----------------------WA-------D D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------ANA-PSGS----SSESRFPPQ----------- ---AASTHRNS---------RL--RNVFGLLAQREVA-PR-TKHSSKRLL---GET-ARK CSGSF------------------------SQIFEAGRDARRGLASW-------------V EAESLHHL----------------------------------RPKY-C------------ -------------PLSPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDCQTGSCLKVLHGHRRTPWV-------- ----------------VRFHPLN-PTIIASGSLDHEVRLWNAST--AECIGSRDFY-RPI ASIAFHASGELLAVASGHK-LYIWRYNM------------------------REET---- ------------------------------------------------------------ S-SPRIVLRT--------RRSLRAVHFHPHAAPLLLTAE--------------------- ----VNDLD------------SSESSLTLATSPGYWRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----VICMAG-------------------------------------------AHSSS- H-----------------------PGLAE-----------EVPLI-TPPF---------- LR--------------P---------------------------------------SFVR DDER------ISLQHTEH-DSGA------------------------------------T RT-------QQSLRSSSSVR-LLTY--------------------STPSGQ--------- -------------------------------YELVLS-PI-------------------- --GSNRSSP----------------------------------MPDGTGTDS-------- ---------------------FVSEIDGALPQ--------------------AA------ -----------------------IGAVGTL------------------------------ ----------------------DGL----------------------------------- --PE-ERT---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------NYLP-------SFGDQTN WEL-----PFLQG---------WFVGQSQ----------------------AAQ------ --CT-TG-LLNGSD-HENLA---------------------------------------- -------------ASGQIENVLNSSAT--------------------------------- -------------------------------------------PISVGQSR--------- ---ASGRSGSGHQSTHSQMMYT-------------------------------------- --PGS-----------------AEGTAFI------------NIPHSESARQP-VTRFQAE VA------------------------------TSV------------------------- ------------------AAAAATEL---------PCTVKLRIWPHDIADPCALLKGESC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRYLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------QP---------------------------------------- ----------------------YLE------TDPGFQS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QGYQDATGAGT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------IYELRIY-------- --------------SLEEAT-------------------------------FGTVLTSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------NLLLAYGRRHS---------SLL---------------- -------KSVLI----DGE----------------------------------------- -----------ITVPT---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPSVGG-- ----GLVYGTK----------------EG-KLRILQFDG--------------------- -------------------------------------------------------SYGMN HTT--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---SCF-M------------------------------------H-------------EN VQL-------VP-------------AQ--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------C--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >GsAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-G---------FP----------------------GP------RR D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------HA---SSS------------------------ ---SSSHNSNS---------SG--SNVFNLLARREIS-PR-TRYVAKWHWGEPGEA-SKS KSIPYS-----------------------RPKKEVVRDARRGLLSW-------------V EAESLRHL----------------------------------SAKY-C------------ -------------PLVPPP----RSTIAAAFSPDGKVLASTHG----------------- -------------------------DHTVKIIDCETGSCLKVLVGHRRTPWV-------- ----------------VRFHPLH-PHILASGSLDQEVRLWDANT--SECIISHHFY-RPI ASIAFHAKGEIIAVASGHK-LYIWHHNK------------------------KGEA---- ------------------------------------------------------------ S-SPIFVLKT--------KRSLRAVHFHPHAAPYLLTAE--------------------- ----VNDLD------------SSDSSMTEATSLGYLQY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVFVTN-------------------------------------------IHPTE- H-----------------------INLSS-----------ELPYV-SLPF---------Y VM--------------P---------------------------------------AYNV DESR------AELQHASH-DVVS------------------------------------G SM-------Q--IESSAMVQ-LQAD--------------------PSAAEH--------- -------------------------------YETTVS-PM---------------DTFSE --MPSSSQT----------------------------------GAEYPAHTA-------- ---------------------FSNGMGIGLSN--------------------LT------ -----------------------MDGMETD------------------------------ ----------------------ETR----------------------------------- --PA-EGNQHGNLTNTYSL----------------------------------------- ----------------------------------------NGM----------------- ----------------LHGLSR-------------------------------------- ------------------------------------QTANRG------------------ --------------------------VPS-------EFGQFHQFFP--------SRDPSG WEI-----PFLHG---------WIMGQSQ----------------------VGV------ --PS-ML-PHMGAS-RDNLSQQIGSSSY-----------------------------IMA SN---------H-STSNVDAAMPSSAI--------------------------------- -------------------------------------------PGSISIPG--------- ---SSMRSGLRNHFSQSRV-PV-------------------------------------- --SES-----------------GNLAASI------------NTPHDGFDMQTIVSRIQSE LA------------------------------TSV------------------------- -------------------AATAAEL---------PCTVKLRVWSHDIKNPCAPLNADRC RLT---------------VPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CM-------------------------- ------------------LP---------------------------------------- ----------------------HIE------ADPGLQT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVHQD-PGVAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAT-------------------------------FGSVLASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------KSIVI----DGE----------------------------------------- -----------TTLPI---YTVLEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPFAGG-- ----GLVYGTK----------------EG-KLRVLQYDG--------------------- -------------------------------------------------------AHAVN GAG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PSYFP------------------------------------E-------------ET IVG-------VS-------------Q---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >GsAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-G---------FP----------------------QP------RR D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------HAS-SSSS------------------------ ---SSSHNSNS---------SG--SNVFNLLARREIS-PR-SRYVAKRHWGEPGEA-SKS KSSPYS-----------------------HPKNEVVRDARRGLLSW-------------V EAESLRHL----------------------------------SAKY-C------------ -------------PLLPPP----RSTIAAAFSPDGKVLASTHG----------------- -------------------------DHTVKIIDCETGSCLKVLVGHRRTPWV-------- ----------------VRFHPLH-PHILASGSLDQEVRLWDANT--SECIISHHFY-RPI ASIAFHAKGEIIAVASGHK-LYIWFHNK------------------------KGEA---- ------------------------------------------------------------ S-SPIFVLKT--------KRSLRAVHFHPHAAPYLLTAE--------------------- ----VNDLE------------SSDSSMTEATSLGYLQY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVFVTN-------------------------------------------IHPTE- H-----------------------ISLSS-----------ELPYV-SLPF---------Y VM--------------P---------------------------------------AYTV DESR------AELQHASH-DVGS------------------------------------G SM-------E--IESAAMVQ-LHAD--------------------PSAAEH--------- -------------------------------YETTVS-PM---------------DTFSE --MPSSSQT----------------------------------GAEYPAHTA-------- ---------------------FSNGMGIGLSN--------------------LT------ -----------------------MDGMETD------------------------------ ----------------------ETR----------------------------------- --PA-EGSQHGNLTNTYSL----------------------------------------- ----------------------------------------NGM----------------- ----------------LHGLSR-------------------------------------- ------------------------------------QTANRG------------------ --------------------------VLS-------EFGQFHQFFP--------SRDPSG WEI-----PFLHG---------WIMGQSQ----------------------VGV------ --PS-ML-PHMGAS-RDNLSQHIGSSS------------------------------IKA SN---------P-STSNVDAAMPSSAI--------------------------------- -------------------------------------------PGSISIPG--------- ---SSMRSGLRNHFSQSRV-PV-------------------------------------- --SES-----------------GNLAASI------------NAPHDGFDIQTIVSRIQSE LA------------------------------TSV------------------------- -------------------AATAAEL---------PCTVKLRVWSHDIKNPCAPLNADRC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------HIE------ADPGLQT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVHQD-PGVAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAT-------------------------------FGSVLASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------KSIVI----DGE----------------------------------------- -----------TTLPI---YTVLEVY-------KVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPFAGG-- ----GLVYGTK----------------EG-KLRVLQYDG--------------------- -------------------------------------------------------AHAVN GTG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PSYFP------------------------------------E-------------ET IVG-------VS-------------Q---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >LjAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-G---------FS----------------------RP-------R D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------HST----------------------------- ---SSSSNSNA---------SG--SNVFSLLARREIS-PR-TKHVAKWHW---GGA-SKS KSSYN------------------------SRSKNVVRDARRGLLAW-------------V EADSLRHL----------------------------------SAKY-C------------ -------------PLLPPP----RSTIAAAFSPDGKVLASTHG----------------- -------------------------DHTVKIIDCETGSCLKVLVGHRRTPWV-------- ----------------VRFHPLH-PQILASGSLDQEVRLWDANT--SECTISHHFY-RPI ASIAFHAKGEIIAVASGHK-LYIWHYNK------------------------KGEA---- ------------------------------------------------------------ F-SPIFVLKT--------RRSLRAVHFHPHAAPYLLTAE--------------------- ----VNDLD------------SSDSSMTEATSLGYLKY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVVVTN-------------------------------------------VHPTE- H-----------------------ISL---------------PYV-SLPF---------F IM--------------P---------------------------------------SFTV DESR------GETLHASH-DV-S------------------------------------V SM-------Q--IESSA-----QVD--------------------TNATE---------- -------------------------------HDTTVS-PM---------------DTVSE --MPSSSQT----------------------------------GTQHPAHAT-------- ---------------------FSNGMGVGINN--------------------LT------ -----------------------RDGMETD------------------------------ ----------------------ETK----------------------------------- --LA-EGSQHGNSTNTYSL----------------------------------------- ----------------------------------------NGV----------------- ----------------LNGLSR-------------------------------------- ------------------------------------QTANGG------------------ --------------------------FFS-------EFGQLQQLFS--------SRDPSG WEL-----PFLQG---------WLMGQSQ----------------------AGV------ --PP-ML-PHIGAS-RDILSQQIGSS-------------------------------VRA SN---------F-SSSNVDAVISSSAM--------------------------------- -------------------------------------------PGSTSIPG--------- ---SSMRSGLRHSFSQPHV-PV-------------------------------------- --SES-----------------GNLAASV------------NIPQDGSDIQAIMSRIQSE LA------------------------------TSV------------------------- -------------------AAAAAEL---------PCTVKLRVWSHDIKNPCAPLNADKC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CM-------------------------- ------------------LP---------------------------------------- ----------------------RIE------ADPGLQA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVHQE-SGLSN------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAT-------------------------------FGSVLASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------KSIVI----DGE----------------------------------------- -----------TTLPI---YTVLEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPFAGG-- ----GLVYGTK----------------EG-KLRILKYDG--------------------- -------------------------------------------------------AHVVS GTG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PSYYP------------------------------------E-------------ET IIG-------VR------------------------------------------------ ------------------------------------------------------P----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >LjAMBRA1b ME---------------------------------------------------------- ------------------------------------------------------------ -----M--------A-KPPPPPPPPPPP----------------------RY-------H D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------HNS----------------------------- ----SSYNPNS---------SG--TNVFRLLAQREIA-PR-TKHVPRWRW---GES-CKS KSGSCS-----------------------HRKSEAVIDAKRGLLSW-------------V EAESLLHL----------------------------------SAKY-C------------ -------------PLLPPP----RSTIAAAFSPDGKVLASTHG----------------- -------------------------DHTVKLMDCQTGNCLQVLVGHRRTPWV-------- ----------------VRFHPLH-QRILVSGSLDQEVRLWDANT--SERILSHYFY-RPI ASLALHASGEIIAVASGHK-LYMWHYNN------------------------GGEA---- ------------------------------------------------------------ F-QPVAVLKT--------RRSLRAVHFHPHAAPYLLTAQ--------------------- ----VNDLD------------PSDYSMTEATSLGYLQY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----VVFVTN-------------------------------------------VQPRT- L-----------------------IHLSS-----------KPPNM-SLR----------L FM--------------P---------------------------------------SYTA DESR------VELQHARH-GVGS------------------------------------S SM-------Q--VE-------------------------------ANETEQ--------- -------------------------------HDTALS-SS---------------E---- --IPASSQT----------------------------------SAEYNAHTT-------- ---------------------SPNQMRTGISN--------------------LT------ -----------------------MGGMETN------------------------------ ----------------------ETQT---------------------------------- -EAA-DVSQHENSAN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GFHQFFP--------SRNPSG WEL-----PFLQG---------WLMGQSQ----------------------VGV------ --PS-ML-HHIGGS-RDSFPQQIGPST-------------------------------MG SN---------P-STTNVEAAMSSSEM--------------------------------- -------------------------------------------PATISIPA--------- ---ASMRSGLQNHFSQSHI-PV-------------------------------------- --SDS-----------------GNLLASV------------NAPRDGSDSQTIINRIQSE HA------------------------------TSA------------------------- ------------------AAAAATEL---------PCTVKLKVWPYDIENPCALLRG--C RLV---------------IPHVVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CM-------------------------- ------------------HP---------------------------------------- ----------------------HTE------GDPGSQN---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LARQD-PGVAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEET-------------------------------FGSVLVSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------KSIII----DGE----------------------------------------- -----------TTLPI---YTVLEVY-------RVSD---------------MELVRV-- ------------LPSADD---------------------EVNVA------CFHPFPGG-- ----GLVYGTK----------------EG-KLRIFQFDR--------------------- -------------------------------------------------------ARTVN GTG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PGYFL------------------------------------A-------------EN FIG-------VG-------------LN--------------------------------- ------------------------------------------------------S----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >MtAMBRA1a MEFS-------------------------------------------------------- ------------------------------------------------------------ -----M-------ES-A-------ELHP----------------------LC-------H D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------QPS----------------------------- ----SSQNSNT---------SG--RNVFSLLAQREIS-PR-NKHVRKCHW---GES-SES KSGCS--------------------------RSGTVVDAKCGLLSW-------------V EAESLQHL----------------------------------SAKY-C------------ -------------PLLPAP----RSTIAASFSPDGKILASTHG----------------- -------------------------DHTVKIIDCETGNCLKVLVGHRRTPWV-------- ----------------VRFHPLQ-RQILASGSLDQEVRLWDASS--SEWILSHYFY-RPI ASLAFHANGEIIAVASGHK-LYMWHYKN------------------------AREL---- ------------------------------------------------------------ S-SPVFVLKT--------RRSLRAVHFHPHGAPYLLTAQ--------------------- ----VNDLN------------SSDCSMTEATSHGHLEY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVFVTN-------------------------------------------VHPRT- Q-----------------------INMSS-----------EPPV---------------- ------------------------------------------------------------ --SR------VELQHASN-DVGL------------------------------------S SM-------Q--VEQYGTRL-VNSE----------------------------------- ------------------------------------------------------------ --IPTSSQT----------------------------------GAEYNAHTT-------- ---------------------LPNQMRIGINN--------------------LT------ -----------------------MGGREAY------------------------------ ----------------------ETE----------------------------------- --PA-EASQHENAD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------HVVKRV------------------ --------------------------ELS-------EHGQFPQIVP--------SPDSNG WEL-----PFLQG---------WLVGQSQ----------------------VGV------ --PS-ML-P-----------QQIGSFT-------------------------------MP SN---------L-FTTNVELAVPPSGM--------------------------------- -------------------------------------------PNGISIPA--------- ---V-LQSGLQNQFSPSRL-PV-------------------------------------- --TDF-----------------GNLVPSI------------NLPHDGFDSQTIINRIQSE LA------------------------------KSV------------------------- ------------------ATAAATEL---------PCTVNLKVWSYDLKNPCAPL--QRC RLT---------------IPHVVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CM-------------------------- ------------------HP---------------------------------------- ----------------------HME------ADPGLQT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LVHQE-PGLPT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAT-------------------------------FGSVLVSRP IRAAH--CLTSIQVLCSLYFLLFFHHNITTFSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------KSIVL----DGE----------------------------------------- -----------KTSSI---YTVLEVY-------RVSD---------------MELVRV-- ------------LSSAED---------------------EVNVA------CFHPFPGG-- ----GLVYGTK----------------EG-KLSVFQFDR--------------------- -------------------------------------------------------TCNVN GTG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---SGYFP------------------------------------E-------------EN IIG-------VN-------------Q---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >MtAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-R---------IH----------------------RN-------R D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------RTGNS---------NG--SNVFNLLARREIS-PR-TKHVA-------------- ------------------------------------RDAKRGLLSW-------------V EADSLRHL----------------------------------SAKY-C------------ -------------PLLPAP----RSTIAAAFSPDGKVLASTHG----------------- -------------------------DHTVKIIDCETGRCLKVLIGHMRTPWV-------- ----------------VRFHPLH-PKILASGSLDQEVRLWDANT--SECITSHHFY-RPI ASIAFHAKGEIIAVASGHK-LYIWHYDK------------------------KGEA---- ------------------------------------------------------------ SYSPIFVLKT--------RRSLRAVHFHPHAAPYLLTAE--------------------- ----VNDLD------------SSDSSMTEATSIGYLQY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVFVTN-------------------------------------------VHPTE- H-----------------------VTLSS-----------EPTNV-SLPF---------F LV--------------P---------------------------------------PYTV DESR------AELQHASH-DAGS------------------------------------G RI-------Q--IESSAVAQ-FQAD--------------------TNSTEQ--------- -------------------------------HDTTVS-PM---------------DTVSE --IPTNSQA----------------------------------GTEYPAHTA-------- ---------------------FSNGMGIGIGN--------------------LT------ -----------------------MDGMETD------------------------------ ----------------------ETR----------------------------------- --PA-EGSQHRNPTDASSL----------------------------------------- ----------------------------------------NGM----------------- ----------------LHGLSR-------------------------------------- ------------------------------------QTANHG------------------ --------------------------VHP-------EDG--HPFVS--------SRDPSG WEL-----PFLQG---------WMMGQSQ----------------------AGL------ --PS-ML-PHTGVS-RDTLAPQISSS-------------------------------VMA NT---------L-PTSNADVAMPSSAM--------------------------------- -------------------------------------------SGSINIPG--------- ---SSVRSGLRSHFSHSRT-PV-------------------------------------- --SES-----------------GNLAASI------------NTPHDGSDIQTIMSRIQSE LA------------------------------TSV------------------------- ------------------AAAAATEL---------PCTVKLRVWSHDIKNPCSPLNADRC RLI---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CM-------------------------- ------------------LP---------------------------------------- ----------------------HIE------ADPGLQT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PVHQE-SGIAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAT-------------------------------FGLVLASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------KSIVI----DGE----------------------------------------- -----------TTLPI---YTVLEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPFPGG-- ----GLVYGTK----------------EG-KLRILHYDG--------------------- -------------------------------------------------------ARPVN GTG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PSYFP------------------------------------E-------------ET IVG-------VS-------------Q---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >SpAMBRA1 MNLN----------------------------C--------------ATKE--------- ------------------------------------------------------------ -----M--------T-G---------LS----------------------FP-------L D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------RNP-LDSP------------------------ ----ASTNPLQ---------SG--RNAFCLLVRREIC-PR-TKHTPKRRW---GEA-SHW NSNSSS-----------------------LPKTEPARDAKRGLISW-------------V EAESLRHL----------------------------------TAEY-C------------ -------------SLVPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDCQTGNCLKVLMGHRRTPWV-------- ----------------VRFHPLH-PEILASGSLDYEVRLWNANT--SECIGSRDFY-RPI ASIAFHAEGELLAVASGHK-LYIWHYNK------------------------RGEA---- ------------------------------------------------------------ S-SPTIVLRT--------RRSLRAVHFHPHGAPFLLTAE--------------------- ----VNDLD------------SSDSSMTRATSPGYLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVFVAN-------------------------------------------GQSSD- R-----------------------ISLAS-----------ELPLV-SFPL---------L FV--------------P---------------------------------------SFSI DDSR------VD---VNR-HATS------------------------------------S TM-------L--VESSTSIQ-PQMD--------------------TNAADR--------- -------------------------------YDPLVS-PM---------------ETFPA --VPSSSYT----------------------------------SAEGIVSDS-------- ---------------------FPSGMGNGVSN--------------------TR------ -----------------------KDAMETD------------------------------ ----------------------EMQ----------------------------------- --TV-GGDLQGNSVNLDTFGV--------------------------------------- ---------------------------------------GNSA----------------- ----------------TDGVPA-------------------------------------- ------------------------------------HTSVRQ------------------ --------------------------QST-------DLGQLQQLVP--------SRDSTR WEL----PPFLQG---------WLMGQSQ----------------------AGV------ --PS-TL-PLNSGG-HELSAQYLSPSA-------------------------------LA SY---------L-STQNVEAAVASLAM--------------------------------- -------------------------------------------PGSTGLSG--------- ---VSGRSSSRHRVSRSRF-SV-------------------------------------- --PES-----------------GESVAPI------------NMQHEGTDNQPIFNRIQSE IA------------------------------TSL------------------------- --------------------AAAAEL---------PCTVKLRVWSHDIEHPCAPLNSDKC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRYLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CM-------------------------- ------------------LP---------------------------------------- ----------------------HME------ADPGLQT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LVHQD-IGTAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAT-------------------------------FGSVLVSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------KSIVI----DGE----------------------------------------- -----------TKSPI---YTVLEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPFAGG-- ----GLVYGTK----------------EG-KLRVLKYDG--------------------- -------------------------------------------------------AHGVC CTG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PSYFP------------------------------------E-------------EN MAE-------VEWNE--------RCRH--------------------------------- ------------------------------------------------------M----- --------------------------L--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >LuAMBRA1 MSRD----------------------------C--------------TNKD--------- ------------------------------------------------------------ -----M--------S-G---------RL----------------------LP-------P D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------QNS-IQSV------------------------ ---RSSNSAHR-------------KNVLRLLAQREIC-PR-GKHVPKKGW---GEA-SRW NVNSPS-----------------------ELKSEPARDAKRDLISW-------------V EAESLRHL----------------------------------SAKY-C------------ -------------SLMPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDCQTGKCLKVLTGHRRTPWV-------- ----------------VRFHPLH-PEILASGSLDHEVRLWDAKT--AECVGFRDFS-RPI ASIAFHAEGQLLAVASGHK-LYIWHYDK------------------------RGEA---- ------------------------------------------------------------ S-SPTVVLRT--------KRSLRAVHFHPHAAPFLLTAE--------------------- ----VNDLD------------SSDSSMSRATSPGYLKY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVFVAN-------------------------------------------VQSSE- R-----------------------VNVAA-----------ELPLM-SLPS---------L FM--------------P---------------------------------------SFSV DDTR------LN---DNR-DVSS------------------------------------S TM-------Q--VESSTPIR-VQLE----------------------------------- ----------------------------------MTP-QI---------------EAYPE --IIPGSFR----------------------------------TLNSGESNY-------- ---------------------IPTRV--GTSA--------------------GV------ -----------------------EDAMETD------------------------------ ----------------------EVP----------------------------------- --HT-RTNQ----LEINAFIE--------------------------------------- ---------------------------------------GNTA----------------- ----------------AVGGNA-------------------------------------- ------------------------------------QGSVQQ------------------ --------------------------HLT-------EFGQLNQFFP--------PRDPVL WEV-----PFLQG---------WLMGQSQ----------------------AGL------ --PS-IL-PLNSAG-REHSSQLSGPS--------------------------------VA PH---------L-SQSNMDPLRASLPM--------------------------------- -------------------------------------------PSSANISG--------- ---VSGRSGLRYHVLRSRF-SG-------------------------------------- --PES-----------------GEGVAPI------------ST-QNSIDAQPILNRIQSE LA------------------------------TSA------------------------- ------------------AAAATAEL---------PCTVKLRVWSHDKQHPCTLLNAERC RLT---------------ISHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRYLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CT-------------------------- ------------------LP---------------------------------------- ----------------------HME------GDPGLQT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LVHND-AGAAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAT-------------------------------FGSVLVSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------KSIVI----DGE----------------------------------------- -----------TTSPI---YTVLEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPFAGG-- ----GLVYGTK----------------EG-RLRVLQYDS--------------------- -------------------------------------------------------AHGSN CFG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PNYFT------------------------------------D-------------DN LAE-------IR-------------TY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------G--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >TcaAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-G---------HP----------------------WP-------L D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------QVS--------------------------LQF ---QSSTNLHR---------SG--KNVLHLLGKREVS-PR-TKYAPERRW---GEA-PKQ NANSSS-----------------------GPNIEPIGDARRGLISW-------------A EEESLRHL----------------------------------SGKY-C------------ -------------PLVPPP----RSTIAAAFSPDGRTLASTHG----------------- -------------------------DHTVKIIDCEMGKCLKVLSGHRRTPWV-------- ----------------VRFNPAH-PEILASGSLDHQVRLWDAKT--AECIGSCDFY-RPI ASIAFHAEGELLAVACGHK-LYIWHYNQ------------------------KGEA---- ------------------------------------------------------------ S-SPAIVLKT--------RRSLRAVHFHPHAAPFLLTAE--------------------- ----VNDLD------------SSDLSMTLATSPGYLHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVLVTS-------------------------------------------SHASD- H-----------------------VGLAA-----------DPSFT-SSPC---------M IV--------------P---------------------------------------SFTI DDSI------MDLQYVSR-LVGT------------------------------------T GM-------L--VGSSSLML-FQTD--------------------ATMGEQ--------- -------------------------------HHSTVS-PM---------------ETFSA --IPSGLCP----------------------------------GTEDPVNNS-------- ---------------------VPFRMESGAAD--------------------PS------ -----------------------MDAMDTD------------------------------ ----------------------EVQ----------------------------------- --PV-RESRETNSTNLNRY----------------------------------------- ----------------------------------------SSA----------------- ----------------RGGVSR-------------------------------------- ------------------------------------NVSNQP------------------ --------------------------DVR-------EFGQLQQFLP--------FG-AIC WEL-----PFLQG---------WLMGQ-Q----------------------TGV------ --PC-MR-PHS-----ENLTQYTGSS--------------------------------ST LQ---------S-STGNMETAAASFGI--------------------------------- -------------------------------------------PNSISQSG--------- ---VSRRTRLQH-VSRSRF-SV-------------------------------------- --SES-----------------GAVAVPS------------NSVHDGADAQQIISRIQSE LA------------------------------TSL------------------------- ------------------AVAAAAEL---------PCTVKLRVWSHDIKNPCALLNADKC RLA---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGKFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------HVE------ADPGLQA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LVHQD-AGVAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------VYELRIY-------- --------------SLEKAT-------------------------------FGSVLISRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------KSIVI----DGK----------------------------------------- -----------TTSPI---YTVLEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPFAGG-- ----GLVYGTK----------------EG-RLRVLQYDG--------------------- -------------------------------------------------------AHGTN SST--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PNYFP------------------------------------E-------------EN MAD-------VE------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >TcaAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------RDS---------SL----------------------WA-------E D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------LNA-PSTS----SSR----------------- --------------------RP--SNVFQLLARREVS-PR-TKRSSRKLW---GEE-PKS RHDSF------------------------GSTCQAARDARRDLLSW-------------V EAESLRHF----------------------------------SAKY-C------------ -------------PLLPPP----RSTIAAAFSPDGNTLASTHG----------------- -------------------------DHTVKIIDCQTGSCLKVLTGHRRTPWV-------- ----------------VRFHPLY-PEILASGSLDHEVRLWNANT--AECIGSRDFY-RPI ASIAFHAQGEVLAVASGHK-LYIWHYNR------------------------RGET---- ------------------------------------------------------------ S-SPAIILKT--------RRSLRAVHFHPYAAPFLLTAE--------------------- ----VNDLD------------SSDSSMTVATSPGYLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----TVYLAD-------------------------------------------AHSSD- R-----------------------SNLAN-----------ELPLV-SLPL---------L IW--------------P---------------------------------------SFAR DNGR------TSLQHTDG-DVGS------------------------------------N GV-------HQRGDQSASVR-LLTY--------------------STPTGQ--------- -------------------------------YELLLS-PI---------------E---- ---PNNSSP----------------------------------LPEETGANP-------- ---------------------LPSEMETDGSH--------------------SA------ -----------------------MEPMETM------------------------------ ----------------------EVQ----------------------------------- --SV-ERS---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------NQFFP--------FGDPTS WEL-----PFLQG---------WLIGQTQ----------------------AGQ------ --RN-MR-LATSAG-HENLLPA-------------------------------------- -------------GETGNSASVVSSGM--------------------------------- -------------------------------------------PTSVSQSR--------- ---VAGRSSLRHRSSRSRMMSS-------------------------------------- --SGS-----------------GEA-GYS------------NIMHDGSDPQPAVNRIQSE LA------------------------------TSL------------------------- --------------------AAAAEL---------PCTVKLRIWPHDMKDPCAFLDPEKC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------HLE------ADPGVQS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QLNPDVTGAST------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HRV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAT-------------------------------FGLVLASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------KSVVI----DGE----------------------------------------- -----------TTVPI---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPSVGG-- ----GLVYGTK----------------EG-KLRILQYDS--------------------- -------------------------------------------------------SNGIN HNS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---SSF-I------------------------------------D-------------EN MLEVGGPSLQVP-------------TY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------C--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >VvAMBRA1a ------------------------------------------------------------ ------------------------------------------------------------ -----M--------R-S---------SF----------------------WV-------D DGS--------------------------------------------------------- ------------------------------------------------------------ ----------------------------VNV-TSTS----SSQTRIPQAVP--------- ---SHHPNSRH---------SG--SNVYRLLARREVA-PR-TKHSLKRLW---GDA-SKW HHNSI------------------------GPRCEAARNARCGLISW-------------V EAESLRHL----------------------------------SAKY-C------------ -------------PLLPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDCQNGSCLKVLSGHRRTPWV-------- ----------------VRFHPLY-PEILASGSLDHEVRLWDAST--AECIGSRDFY-RPI ASIAFHAQGELLAVASGHK-LYIWHYNR------------------------RGET---- ------------------------------------------------------------ S-SPTIVLKT--------RRSLRAVHFHPHAAPFLLTAE--------------------- ----VNDLD------------SSDSSMTLATSPGYLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----TVYLAD-------------------------------------------AHSSD- R-----------------------SSLAD-----------ELPLM-SLPF---------F IW--------------P---------------------------------------SFAR DDGR------ISLQHTDG-VAGP------------------------------------S IA-------QQRVDHSTSVR-LLTY--------------------STPSGQ--------- -------------------------------YELLLS-PM---------------E---- ---PSSSSP----------------------------------MPEETGTNS-------- ---------------------FLREMENSVPQ--------------------PA------ -----------------------MDAMDTT------------------------------ ----------------------EVQ----------------------------------- --PE-ERS---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------NQFFP--------FGDPSY WEL-----PFLQG---------WLIGQSQ----------------------AGQ------ --RT-IR-PLSGSG-HENPSSF-------------------------------------- -------------GETETPAPMVSSVM--------------------------------- -------------------------------------------STSISQSR--------- ---VTGRSSSRHRSSRSR--AA-------------------------------------- --TGS-----------------AEG-AFL------------NIGQDESGLQPVVSRIQSE LA------------------------------TSL------------------------- ------------------AAAAAAEL---------PCTVKLRIWPHDIKDPCASLDAERC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CM-------------------------- ------------------LP---------------------------------------- ----------------------HLE------ADPGSQG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QMHHGVTGAAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAT-------------------------------FGLVLASRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HLLLAYGRRHN---------SLL---------------- -------KSIVI----DGE----------------------------------------- -----------TTVPI---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPSVGG-- ----GLVYGTK----------------EG-KLRILQYDS--------------------- -------------------------------------------------------SHGMN YTS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---SCF-L------------------------------------D-------------EN MLE-------VP-------------TY--------------------------------- ------------------------------------------------------A----- --------------------------LE----------------------C--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >VvAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------K-HMIER-----PS----------------------RP-------H D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------PTV-VSSS------------------------ ---PSGPSSHH---------SG--RNVLQLLAQREIC-PR-SKQFPKRLW---GGS-SEQ NAESFF-----------------------GPKSEAARDARRGLISW-------------V EADSLQHL----------------------------------SARY-C------------ -------------PLMPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDCHTGSCLKVLTGHRRTPWV-------- ----------------VRFHPVH-PEILASGSLDHEVRIWDANT--AECIGSRDFY-RPI ASIAFHAKGELLAVASGHK-LFVWHYSR------------------------RGET---- ------------------------------------------------------------ S-SPTIILKT--------RRSLRAVHFHPHGAPVLLTAE--------------------- ----VNDLD------------SSDSSMTRATSPGYLHY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVFLAN-------------------------------------------IHSSD- R-----------------------LKLAS-----------ELHLA-SLPF---------S FI--------------P---------------------------------------SFAR DDSR------IDLYHTDR-PTGS------------------------------------T RV-------Q--MGSSGSVQ-FQAD--------------------ANAAGQ--------- -------------------------------YDYMVF-PM---------------ETSPV --LPSCSNP----------------------------------STEGTQINC-------- ---------------------VPNGMENGIPD--------------------PK------ -----------------------MDAMDST------------------------------ ----------------------EMQ----------------------------------- --PV-EQNQHRSSANLDTFSG--------------------------------------- ---------------------------------------ANSA----------------- ----------------SRGVPG-------------------------------------- ------------------------------------HISSLP------------------ --------------------------ESI-------EFGHLHQFLP--------CRGPKY WEL-----PFLQG---------WLMGQSQ----------------------AGV------ --SP-ML-SLNGAS-HEHSSQNLGMGSA-----------------------------ILN PD---------L-STSNIEVPVISPAM--------------------------------- -------------------------------------------AGSINLPG--------- ---VAGRSGQQQRFSRSHLISV-------------------------------------- --SES-----------------VEQAASI------------NIAHEGSDTPPIMSRIQSE LA------------------------------ASL------------------------- ------------------AAAAAAEL---------PCTVKLRIWSHDLKNPSAVLNAEKC LLI---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHLSPCGRFLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CV-------------------------- ------------------LP---------------------------------------- ----------------------HLE------ADPGLQT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QVQDA-IGAST------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPVSA------------------------- ------------------------------------------------------------ --------------------HHV------------------------------------- ---------------------------------------------MYELRIY-------- --------------SLEEAT-------------------------------FGTVLVSRA IRAAH--CLTSIQ-----------------FSPTSE------------------------ ---------------------HILLAYGRRHS---------SLL---------------- -------KSLVI----DGE----------------------------------------- -----------TTLPI---YTILEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPLPGG-- ----GLVYGTK----------------EG-KLRVLQYDV--------------------- -------------------------------------------------------SHGMN SNG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PNSFL------------------------------------G-------------EN LAE-------LE-------------QY--------------------------------- ------------------------------------------------------PRFR-- ------------------------QMLS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------NGRNL--------- --------------------- >PtAMBRA1b ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-P---------VS----------------------LP-------L D----------------------------------------------------------- ------------------------------------------------------------ ----------------------------RNP-PLNP------------------------ --------PLL---------SG--RNALCLLVQREIC-PR-TKHTPKRRW---GEA-SQW NYNSSS-----------------------VPKTEPARDAKRGLISW-------------A EAESLRHL----------------------------------SAQY-C------------ -------------PLVPPP----RSTIAAAFSPDGKTLASTHG----------------- -------------------------DHTVKIIDCQTGICLKVLMGHRRTPWV-------- ----------------VRFHPLH-PEILASGSLDHEVRLWDANT--SECIGSRDFY-RPI ASIAFHAEGELLAVASGHK-LYIWHYNK------------------------RGEA---- ------------------------------------------------------------ S-SPTIVLKT--------RRSLRAVHFHPHGAPFLLTAE--------------------- ----VNDLD------------SSDSSMTRATSPGYLRY---------------------- ------------------------------------------------------------ -----------------------------------PPP---------------------- -----AVFVTN-------------------------------------------GQSGD- C-----------------------VSLAS-----------ELPLV-SLPF---------L FV--------------P---------------------------------------SFSL DDSR------ID---ANR-LVTS------------------------------------S TM-------Q--VESSTSMQ-LQMD--------------------TNATDR--------- -------------------------------YVPLVS-PM---------------ETFPA --VPSSSYT----------------------------------SAEGIVNNS-------- ---------------------FPSGMGGGVSN--------------------TR------ -----------------------EDAMETD------------------------------ ----------------------EMP----------------------------------- --PV-GGNPQGKSAHLEMLGV--------------------------------------- ---------------------------------------GNSA----------------- ----------------MDGVPA-------------------------------------- ------------------------------------NTSIRQ------------------ --------------------------QST-------DFGQLQQILP--------SRDSTW WEL-----PFLQG---------WLMGQSQ----------------------AGG------ --PS-TV-PLSSGS-RERSAQYIGPSS-------------------------------LT SY---------L-STQNVEAAVASLAM--------------------------------- -------------------------------------------PGSTSISG--------- ---VSGRSGSRPRISRSRF-FV-------------------------------------- --PES-----------------RESMAPI------------NMRHEGSDNQPIFNRIQSE IA------------------------------TSL------------------------- ------------------EAAAAAEL---------PCTVKLRVWSHDIKHPCAPLNADKC RLT---------------IPHAVL------------------------------------ -------------------------------------------CS--------------- ------------EMGAHFSPCGRYLAACVA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CM-------------------------- ------------------LP---------------------------------------- ----------------------HME------ADPGLQT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LVHQD-AGAAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPTR---HPISA------------------------- ------------------------------------------------------------ --------------------HQV------------------------------------- ---------------------------------------------VYELRIY-------- --------------SLEEAT-------------------------------FGSVLVSRA IRAAH--CLTSIQ-----------------FSPMSE------------------------ ---------------------HILLAYGRRHG---------SLL---------------- -------KSIVI----DGE----------------------------------------- -----------TTTPI---YTVLEVY-------RVSD---------------MELVRV-- ------------LPSAED---------------------EVNVA------CFHPFAGG-- ----GLVYGTK----------------EG-KLRVLKYDG--------------------- -------------------------------------------------------VHGVN CTR--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PNHFP------------------------------------E-------------EN 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SSQRG--FPDEG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------I--LAVY-------- --------------SLAPHN-------------------------------LGEMLYTKR FGP----NAISVS-----------------LSPMGR------------------------ ---------------------YVMVGLASRRI---------LLHP--------------- ----------------STE----------------------------------------- -------------------HMVAQVF-------RLQQPH----------GGETSMRRVFN VL----------YPMPAD-----------QRRHV-----SINSA------RWLPEPGL-- 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--VGSGSLYDALALGMEMGNPPSSPPPYLIASSEDGSPQVIGQSTSDDDDDDDEEEREEA AAGSSVAVGTGTGTDAGERSGSLQSNRVLLPPQPPPAAAATAEAGFRERLPPDLQSNFSL SDEWLGFSDADTAGSEAGGGQASLRESLGFVLSSLEQESPAINVVDAAGRESGDDDDDDD GRAEDIDGHIEDMYFSQYSEW >PfAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------T-NS------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TT--ESFLHNLVKREVG-LF-N------------------ ------------------------------------GRHRVSLDRF-------------V EDKAAVFST---------------------------------DNKP-C------------ -------------ELAGQP----RATFLMSFSPDGNLMASNHG----------------- -------------------------DHNVHVTDVRTGENTHTLIGHPRTPWC-------- ----------------VSFHPTS-NDILASGCLAGEVRIWDLHG--GSESWKADTD-AAI ASLAFHPTDQVLAIATDDR-LYLWDWGL-------------------------------- ------------------------------------------------------------ P-TPFTYVKTA---NP--KEKIRLVKFDPIGH-YLLTGI--------------------- ----SNIING----------DSDDELDLSLPSSSLHPSDAQERNVVP---------FSSY D---HRLVRRL--------------------------------------RQQLIRQSDSY NNPQDVAD---------------------------------------------------- -----AVFTNPNN---------------------------------------LDVHSPNR EESGS----------------NNQPGSSHIS---------------AMPH---------- ----------------PMRN-QDSALSGTSAMPHPMRNQ--DSALSGT-----------S DTIS------QNMQSLPGETASSQ------------------------------AAGGRN DS-------STSDFEGFRMN-LAAA---------------LLH--STAQVSMNVPSNSNR -------------------------------QPSNTE----------------PGFLNPS ----SNSNILHHSPV---------------------------TTRRRLFNPS-------- --------------------AIRVSVESDPAN---------------------------- -------------------------SLSAD------------------------------ ------------------VPQPDGQ----------------------------------- -----SSSSNSDSD---------------------------------------------- ------------------------------------------------------------ ---------------SPPGPP--------------------------------------- ------------------------------------------------------------ -------YISQIS-QQHADI-------------------ALASLLP--------EGDRPY SNL---SVRRMNSSI-I--LSRSRSG-SSVALPRGR------------LEFSGTNNEPAS QDSHRFANP-----------------EVSTSPRY---TTRTFRRSPLRSS------RLNV SQ-------PRRSMSDDSS-VS-------------------------------------- -------------------------------------------SPGSET----------- ---------------RRARMTRFG----------------------------------FQ RST-ERSRLHHFHHHHVNNLHQHYSTSVFDDT---------N-----RPSPALHSAINRA IA------------------------------GAFAGN---------------------- -----------------GETAVASNI--------VNTTHRLQWWDFTSCQ-LPNISDSDV NVI---------------VPHCKL------------------------------------ -------------------------------------------HN--------------- ------------DASCDISQDGTMLAAFVP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SHRG--FPDDG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------I--MAVY-------- --------------SLQTYN-------------------------------FGDCLFTKS FGP----NAISVS-----------------ISPANN------------------------ ---------------------YVMVGLASRRL---------HWHV--------------- ----------------TSK----------------------------------------- -------------------QMVAQIF-------RLREAY----------AGEDSCQHIQN VM----------HPCDVE-----------RRTHI-----SVNSA------KWLPFPGG-- ----GVVYGTN----------------RG-DLHVCRIRLPPIPEDPPRVCVDNSR-TPPR HFHTHSDNMY---ARRNIDT-VGRV---------RDYQMLGVVGLGLTLPP----ETNST STQTPSVQVQSASTQTDST--------------------------D-------------- ---------------------------------------------SSVDNET-------- ------------------------------------------------------------ ---PSVIH---------------------------DDSTADTQGDRAASRAGSGDASGNG L-------HNTDGNS--------SASG--------------------------------- ------------SSYSDA--SV-------------------------------------- ------------------------------------------------------------ --------------------------PTMYDSSSDTS-G--------NRTDD-------- ----------------------------------------------------DVIDMNSD SDS--------------------------------------------------------- --------------------- >AfAMBRA1 M----------------------------------------------------------- ------------------------------------------------------------ -----M--------Q-RR------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------ADSAQVTP----ASASRCTP------------ ---RQTNESRS--------DRTEATGLINFRRQHRSA------------WEA-GHA---- -------------------------------------------SHW-------------R RIETRQSVNPE-------------------I--------IPASAAHTA--HL-------- ------------GRVPDTP----PPTASESNDPNTQEAASTSSA---------------- -----------------------GGDRSMETEVAESSR---------------------- --------------------PTL---LMAS------------------------------ ------PCPNIPPVASPSA-LPPSSYSP-------------------------------- ---------------------------------------------------------H-- S-SPHSSPHA--------RRTIPALLHHGHARRHIYHMG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QDRS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------LRREREESGP-------------- ---------------------------------------------------SGG------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------ETRRARVSRYTFGRTS----------------------------------LG RRT-SQAALHRHYARH--------GSSIFDEE---------N----RPPSSSIHQYINRA IA------------------------------NAFAGR---------------------- -----------------GETAVANNI--------GNTTYRLQWWNFQDFQ-LPDISRAEI NVV---------------VPHCKL------------------------------------ -------------------------------------------HN--------------- ------------DASCDIAQDGSLLAVFVP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SPLG--FPDDG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ELAIY-------- --------------SLQEHN-------------------------------FGDVMYTKS FGP----NAITVS-----------------LSPLGG------------------------ ---------------------YVMVGLAARKL---------HWSA--------------- ----------------STK----------------------------------------- -------------------QLMAQIF-------RLARP-----------GTDDSLVHIMD VN----------HPSESD-----------QRIQI-----SVNIA------KWLPQPGR-- ----GFVYGTS----------------RG-HLRICTPRYMPCDEAEDGAQSDA------- --DTESSDDE---ITRRINL----------ARRRRSYQELRSLALSSVSSAGSIPERRAR GTQTARRIQFSIATQTDDVGTHHTSAQSSTGEGR------------EG-----SG----- -SNTPDT-----------------------------------QSTSSG------------ ----------SSGSLNLPSTSSRSV---------------------------------GH PDIPTVSS---------SSAGHFDLPSTSSRSVGHPELPSTSSVEHSDMLSSSSNISSRN LDI-PTSSTTVEPSDISVISIGQPSTS--VTNTT-------------------------- ------------VEHSDI--SVIS---------------------------IEQPDTS-- --------------------------VTSRRDCGRSD----------------------- -------------------------IPSTSNSNTDHD-R--------ISDDD-------- ----------------------------------------------------NLISVDRD TST-------------------------PII-----GEDITITMPDESAMS--------- --------------------E >MeAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SNIASYLSKREIG-SN-NKR---------------- ------------------------------------WNTKDKVQDY-------------F DEIGSKPV----------------------------------INKA-C------------ -------------SLSRRC----RATFLVDFSCDRTKIASTHG----------------- -------------------------DHSVRITDAATGKCTHVLEGHPRTPWC-------- ----------------LAFHPSS-NQIVASGCLDGEVRIWDLFGG-GSEVWRCKEH-TVI ASLTFHPTDNLLVFAAGNS-VYFWDWTK-------------------------------- ------------------------------------------------------------ P-EPFAVCSTK---HD--FERVRWVKFHPHGH-HLYTGI--------------------- ----TNTATL----------QQSNSSRVSFISGRPSF-------------VQRTRGLSNV Y---DNLVECF----------------------------------QTY-------QRDRV INLATAGSG-----PIG-----NTADLD------TPPS--------------PVHEEGLN FARQYARHITE-------------------------------------------TAASEA AEQDDV-----------IPSEDQGPSSST-----G------------------------- ----------------PSLS---------------------------------------- ----------------------------------------------------------GD FS------------------------------------WSPPP--RTAPSEEAM------ -------------------------------DNSATARPVIIVSNSHER---------PP --RPLNSSRLSAGII----------------GNRRTDNLYRHMFRQNNNDSA-------- ------------------SGSLTNLRRSPLSR-------------PRSILDHSNCDGHCD --------------------VCRNYNLTVH-------------NR--------------- ------------------RNQSSLQ----------------------------------- -----SRQERLES---------------RRRYCRDRLM---ALRRRQND--LPTCSFNER SSIYS--------------------DN-------SSERLSGHNQPRFN------------ -------------ISSSPDQPEASA----------------------------------- ---------------------------------SGQSSVDRNMNISESAN---------- -------STSSMT-ENYDNI----------RNNFVSITTRLEQEMN--------ELDRRI NDL---RNSFQESIRQL--QVEHGIGEASDEQSQNRDVPLNQQVTRPVITVTGCRES--- HDSEQSQ-PGNQQT----------------RDRTH-LLE--------------------- ---------TALRTSVSSPRQSLPTPP--------------------------------- ------------------------------------------------------------ --VVSSNSSSRTEVSSSSSNTWQTL----------------------------------- ----QRHHLHPHY-----------SVSILDDT--------IN-----RPHDAVQRAINHT IA------------------------------GAFMGR---------------------- -----------------GEAAVASNI--------VNQTYRIQYWDMVANA-VPDISDEKV NII---------------VPHCKL------------------------------------ -------------------------------------------HN--------------- ------------DASCDISQDGTLLATFAP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SHRG--FPDDN------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------I--MAVY-------- --------------SLLPQT-------------------------------VGQCLYTKS FGP----NAISVS-----------------ISPRNQ------------------------ ---------------------HVLVGLAAKRL---------IWVF--------------- ----------------TTN----------------------------------------- -------------------QLVGQIY-------KLDNAN----------TGENSTKHVMD IM----------HPCDID-----------IRSHV-----SVNSA------RWMPTPGH-- ----GLVYGTN----------------RG-DLQICRPGSLKVSEDEERASTSSSI----- --------------------------------SRRNILLDHMLGGISRTPV----TVNSI ATQTPAVR-RSMSTQTDES--------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SN VIV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >OfAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------R-RR------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------KG--CNVLSALIRRETN-CR-R------------------ ------------------------------------TNDHDLLLSY-------------V EDVSVMSCN---------------------------------RTEE-C------------ -------------ELPGSP----RSTFLVCFSPDKTKMASSHG----------------- -------------------------DHTVRVVDCKTFKCVKTLKGHPRTPWC-------- ----------------ITFHPSS-DQLLASGCLGGQVRVWNLET--GESEVYTPPDKAVI ASLAFHPTDHVLLIATSNK-LLCWSWDQ-------------------------------- ------------------------------------------------------------ P-EPFACIQTA---SI--EEKVRLVAFSPLGD-HILTAV--------------------- ----TNIVSQ-----------MDDNPRTYAPS--------------------RSPVVNRL L---QSMGNSR------------------------------------------------- -----------------------------------EPG---------------------- -GDNFSAHVLR------------------------------------------------- ------------------------PSAAS------------------------------- --------------NSPATS---------------------------------------- SSTS------TNSDSMPKSSSTTG------------------------------------ --------------------------------------LNSPG--STENSNLEPVT---- -------------------------------REGEAISSSITSQTDV-----TEGDVTDN -------------------------------GNQDYRGVFA-IFRARDNNIW-------- --------------------NFDVTSEASPSA---------------------------- ----------------------------------------------VL------------ ----------------------DQE-------------------------------PNAV NFDS-DSSNEGEGVSMSLSTGDTDVYSD-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----VGEATA------------------------------------------------- ------------------------------------NSDSIEQSVP-------------- ---------------------------------------FE----------AGP------ --------PSEEAS-----------------DRVV-GVGRVINVAPSSSR------TSFL SH-------GSNHSSSFAT--------------------------------LGG------ -------------------------------------------SPGYGTAV--------- --ATATARTLRHV----------------------------------------------- ----------------------HTAVVVADGT--------NG-----GPQFALRSAINRA IA------------------------------GAFAGC---------------------- -----------------GEGAVASNI--------INTTHRLQWWDFSQVK-LPDLKNSES NLI---------------ASSCKI------------------------------------ -------------------------------------------HN--------------- ------------DASCDISSDGKLLATFVP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------STQG--FPDDG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------V--VAVY-------- --------------SLEKTT-------------------------------LGHCVFSKK FGP----NAISIS-----------------LSPRNR------------------------ ---------------------YIMVGLAARRL---------HLHL--------------- ----------------TSR----------------------------------------- -------------------QMVAQIF-------RLTKKD----------SSFDEAKPIVS VM----------HECDAD-----------RRSHV-----SVNAA------FFHPLVGN-- ----GLVYGTN----------------RG-HLHMRQFGP--------------------- --------------------------R--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PAFRY--------------------------------------------------SH LTT--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >human_outgroup1_KATNB1 ------------------------------------------------------------ ------------------------------------------------------------ -----MAT-----PV--------VTKTA----------------------WK------LQ E--------I-----------------------------------------------V-- ------------------------------------------------------------ ----------------------------AHA----------------------------- ------------------------SNVSSLVLGKASG----------RLLATGGDD---- ----------------------------------------CRVNLWS------------- ------------------------------------------INKPNCIM---------- -------------SLTGHT----SPVESVRLNTPEELIVAGSQ----------------- -------------------------SGSIRVWDLEAAKILRTLMGHKANICS-------- ----------------LDFHPY--GEFVASGSQDTNIKLWDIRR--KGCVFRYRGHSQAV RCLRFSPDGKWLASAADDHTVKLWDLTAGK--------------MMSEFPGHTGPV-NVV EFHPNE----------------------------------YLLASGSSDRTIRFWDL--- --EKFQVVSCIE--GE--PGPVRSVLFNPDGC-CLYSGCQDSLRVYGWEPE-RCFDVVLV NWGKVADLA------------ICNDQLIGVAFSQSNV----------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----SSYVVDLTR----------------------------------------VTRTGT VARDPVQD-------------HRPLA-------------------QPLPN--PSAPLRRI Y-------------ERPSTT-CSKPQR-VKQNSES-------ERRSPSS---------ED DRDE------------------------------------------------------RE SR-------AEIQNAEDYNEIFQPKNSISR---------TPPR--RSEPFPAPPEDD-AA TAKEAA------------------------------------------------------ --KPSPAMD--------------------------------------------------- ------VQFPVP--------NLEVLPRPPVVA--------------------STPAPKAE P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------AIIPATR----------- ------NEP------------------------------------------IGL------ -KASDFL-PAVKIP---------------------------------------------- ----------------QQAELVDEDAM--------------------------------- ----------------------------------------SQIRKGHDTMC--------- -----VVLTSRHK----------------------------------------------- ------------------------NLDTVRAV---------------WTMGDIKTSVDSA VAIN-------------------------------------------------------- ------------------DLSVVVDLL-------NIVNQKASLWKLDL-----------C TTV---------------LPQIEK------------------------------------ -----------------------------------------LLQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------KYESYVQ-------- ---TGCTSL-----KLILQR-------------------------------FLPLITDM- -------------L----------------AAPPS------------------------- --------------------VGVDISREERLH---------------------------- -------KCRLC------------------------------------------------ -------------------YKQLKSI--------------------------SGLVKS-- ---------------------------------------KSGLS---------------- ----G-RHGST--------------FR---ELHLLMASL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------D- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >human_outgroup2_WDR5 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------A-------------------------------------------TE EKKPE------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TEAARAQPTP----------------------- -----------------------------------------------------------S SSATQSKP-------------------------------TPVKPNYALKF---------- -------------TLAGHT----KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC-------- ----------------CNFNPQ--SNLIVSGSFDESVRIWDVKT--GKCLKTLPAHSDPV SAVHFNRDGSLIVSSSYDGLCRIWDTASGQ------------------------------ ------------------------------------------------------------ ------CLKTLI-DDD--NPPVSFVKFSPNGK-YILAAT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LD NT---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LKLWDYSK------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GKCLKTYTG------------------------------ -HKNEKY----------------------------------------------------- ------------------------------------------------------------ --------------------------------CI-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------FAN------ ------------------------------FSVTGGK----------------------- -----------------------------------------WIV---------------- ----------------SGS----------------------------------------- ------------------EDNLVYIW-------NLQT---------------KEIVQK-- ------------LQGHTD---------------------VVIST------ACHPTENI-- -IASAALENDK-------------------TIKLWKSDC--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >zebrafish_outgroup_katnb1 ------------------------------------------------------------ ------------------------------------------------------------ -----MAL-----TN--------TTITS----------------------WK------LQ E--------I-----------------------------------------------V-- ------------------------------------------------------------ ----------------------------AHS----------------------------- ------------------------SNVSSLVLGKSSG----------RLLATGGED---- ----------------------------------------CRVNIWA------------- ------------------------------------------VSKPNCIM---------- -------------SLTGHT----SAVGCIQFNSSEERVVAGSL----------------- -------------------------SGSLRLWDLEAAKILRTLMGHKASISS-------- ----------------LDFHPM--GEYLASGSVDSNIKLWDVRR--KGCVFRYKGHTQAV RCLAFSPDGKWLASASDDSTVKLWDLIAGK--------------MITEFTSHTSAV-NVV QFHPNE----------------------------------YLLASGSADRTVKLWDL--- --EKFNMIGSSE--GE--TGVVRSVLFNPDGS-CLYSGSENTLRVYGWEPD-RCFDVVHV GWGKVSDLA------------ISNNQMIAVSYSHTNV----------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----SWYVVDLNR----------------------------------------VKKSGS VIQGLIQD-------------KPIPA--------------------PSSA--LGTTLRRN Y-------------ERPTTS-CTGQE--MKQSSEADRRSPEGERRSPSS---------ED EKED------------------------------------------------------KE SS-------AEITNPEDYKEIFQPRSVISR---------TPPK--TTEPFPAPLEH--SF SESVLE------------------------------------------------------ --KPGPVVK--------------------------------------------------- ------IVTPVI--------DRAGQLKGPITS--------------------STPVQRVE PTVIAAAP-------------------------------------------RPVAVV--- ------TTSASSP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------SRPVVNTTK------------------------------------ ------------------------------------------------------------ -------------------------------------PKPSTGIILSTR----------- ------NEP------------------------------------------IGL------ -NAGDFL-SHARNA---------------------------------------------- ----------------KASAMGDEEAL--------------------------------- ----------------------------------------AQIRKGHDTMC--------- -----VMLSSRSK----------------------------------------------- ------------------------NLDSVRSV---------------WASGDVKTSLDSA VSMN-------------------------------------------------------- ------------------DLSIVVDVL-------NIINLKPSLWKLDL-----------C TSI---------------LPQIEE------------------------------------ -----------------------------------------LLQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------RYESYVQ-------- ---TGCMSL-----KLILKR-------------------------------FWPLISDT- -------------L----------------NAPPS------------------------- --------------------VGVDITREERHQ---------------------------- -------KCKAC------------------------------------------------ -------------------YKQLKNL--------------------------SNVVKN-- ---------------------------------------RAEQV---------------- ----G-RHGST--------------FR---ELQLLMAPL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------D- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------Y------- >seaUrchin_outgroup_katnb1 ------------------------------------------------------------ ------------------------------------------------------------ -----M-----------------ATKRA----------------------WK------LQ E--------L-----------------------------------------------V-- ------------------------------------------------------------ ----------------------------AHS----------------------------- ------------------------SNVNCLALGPMSG----------RVMVTGGED---- ----------------------------------------KKVNLWA------------- ------------------------------------------VGKQNCII---------- -------------SLSGHT----SPVDSVKFNSSEELVVAGSQ----------------- -------------------------SGTMKIYDLEPAKIVRTLTGHRNSIRC-------- ----------------MDFHPF--GEFVASGSTDTNVKLWDVRR--KGCIYTYKGHSDQV NMIKFSPDGKWLVTASEDTTIKLWDLTMGK--------------LFQEFKNHTGGV-TGI EFHPNE----------------------------------FLLASGSSDRTVQFWDL--- --ETFQLVSSTS--PG--ASAVRSISFHPDGS-YLFCSSQDMLHAFGWEPI-RCFDTFSV GWGKVADTV------------IASTQLIGASFNATNV----------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----SVYVADLSR----------------------------------------MSTTGI AQEPQSQP-------------SKTPSGGA----------------EEVPSKPLTASGRKN FV---------R--ERPHTT-SSKQRQ-PDVKSEP-------ERQSP-T---------QD EGVK------------------------------------------------------DD DA-------TDIKDPDSYAKIFSPKTRVDH---------SPER--NAQPFPAPLDV---- -------------------------------PGAQEPEPFKHPP---------------- --KPAAAAA--------------------------------------------------- --------------------VAPVSRAPAPSA--------------------SDWQPAQA NP-------------------------------------------------APNRVP--- ------AATKPVP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------AQEVAPSRK------------------------------------ ------------------------------------------------------------ -------------------------------------PDPISTIIPSDR----------- ------NKP------------------------------------------ANL------ -DMDAFL-PPAHAQ---QAPRV-------------------------------------- -------------NAPASRKQSDSERI--------------------------------- ----------------------------------------EGLRKGHDSMC--------- -----QVLSSRHR----------------------------------------------- ------------------------NLDVVRAI---------------WTAGDAKTSVESV VNMK-------------------------------------------------------- ------------------DQAILVDIL-------NIMLLKKSLWNLDM-----------C VVV---------------LPRLKE------------------------------------ -----------------------------------------LLSS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------KYENYVH-------- ---TSCACL-----KLILKN-------------------------------FTSLFNQN- -------------I----------------KCPPS------------------------- ---------------------GIDITREERYN---------------------------- -------KCSKC------------------------------------------------ -------------------YSYLIAT--------------------------RGYVEE-- ---------------------------------------KQHVS---------------- ----G-KLGSS--------------FR---ELHLLLDQL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------E- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >limpet_outgroup ------------------------------------------------------------ ------------------------------------------------------------ -----M--------A--------QQKRG----------------------WK------LQ E--------F-----------------------------------------------L-- ------------------------------------------------------------ ----------------------------AHG----------------------------- ------------------------ANVQCLALGHKSS----------RVMVSGGED---- ----------------------------------------RKVNLWA------------- ------------------------------------------VGKPNCIM---------- -------------TLTGHT----TTVSAVRFGNAEEMVVAGSQ----------------- -------------------------SGALKVWDLEQAKIMRTLTGHTAGVNA-------- ----------------LDFHPF--AEFVGSGALDSNIKLWDIRR--KGCIKTYKGHANGV NCLRFSPDGKWIASAGGDGIIKLWDLAAGK--------------LVADLKLHQGPV-NVV EFHPNE----------------------------------VLLASASSDKTVKFWDL--- --ETLKLVSSSD--KE--SKQVSSMWFHPEGK-CLYAGAEDSLKVYGWEPY-VCYDSVPL VWGAVSDIS------------FRQDQLIGVAFSQLNV----------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----SVHVVDLSK----------------------------------------VRPMGV NSEPDIR-----------------------------------------PS--LSSSGRRS FM---------S--DRPPTS-SARQSSVNKEDEES-------------S---------VM SDNV------------------------------------------------------ED NR-------ADIQNEDDYKELFRTRSKIAR---------SPVR--HSEPFKPPFDD--EE RKR-------QIAE---------------------------------------------- ------------------------------------------------------------ --------------------------KQRLQD---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KQRLAEKQK------------------------------------ ------------------------------------------------------------ -------------------------------------ELDRQNELESER----------- ------KKK------------------------------------------EEE------ -RQRVID-QKRKEQ---QDRER-------------------------------------- -------------KQKQQQQQQSNDSL--------------------------------- ----------------------------------------GSIDKGHTAML--------- -----TVMSSRSR----------------------------------------------- ------------------------NLQIVRAM---------------WTSGNTKTAVDSA ISMN-------------------------------------------------------- ------------------DQAVMVDIL-------NVLNFKPTLWTLDL-----------C SIL---------------LPQLKD------------------------------------ -----------------------------------------LLNS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------KYECYVT-------- ---TTCQSL-----KLILKN-------------------------------MGPVIKAN- -------------I----------------SSAPS------------------------- --------------------IGVDISREERHQ---------------------------- -------KCNAC------------------------------------------------ -------------------YQTLMAV--------------------------RTLIEK-- ---------------------------------------RQAIP---------------- ----G-KLGNM--------------YK---QLQILMGTL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------D- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >leech_outgroup ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ E--------F-----------------------------------------------V-- ------------------------------------------------------------ ----------------------------AHS----------------------------- ------------------------SKVTCLKLSQKNP----------HLLATGGQD---- ----------------------------------------MKVNLWS------------- ------------------------------------------LDSANCQM---------- -------------VMSGHE----SPLQSLSFHKSGTKLGGGCK----------------- -------------------------KGVFKIWDLQNAKLTHTFSNHKSTLNC-------- ----------------IEFHDF--GDFVATGSADQQIKLWDLKR--KGSIMTYKGHSSAV TCISFSPDGRWMASGDDDGVVKIWNMATHK--------------QLCQFDDHKQSI-NCI KFHPIE----------------------------------LLMITSSADCSMKIWDM--- --DEKKLLASIKIDDS--EGPIRLAMFDADGS-KLFSLTTKHLRIHGWEPT-HCFATVDI NHQNTNHAI------------LSNNQMV-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------NYSQIFS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------YNLLLKII-------ALLVVSQKIFK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >honeybee_outgroup_katnb1 ------------------------------------------------------------ ------------------------------------------------------------ -----M-------AS--------STKRS----------------------WK------LQ D--------F-----------------------------------------------V-- ------------------------------------------------------------ ----------------------------AHS----------------------------- ------------------------SNVNCLALGHKSG----------RVLVTGGDD---- ----------------------------------------KKVNLWA------------- ------------------------------------------VGKQNCIM---------- -------------SLSGHT----TPIECVRFGQTEDLVCAGSQ----------------- -------------------------TGALKIWDLEHAKLARTLTGHKAGIRC-------- ----------------MDFHPY--GELLASGSLDTAIKLWDIRR--KGCIFTYKGHNRMV NSLKFSPDGQWIASAGEEGMVKLWDLRAGR--------------QLREFSEHRGPA-TTV EFHPHE----------------------------------FLLASGSADKTVHFWDL--- --ESFQLVSSTD-QSH--SSAIRCLYFSQGGE-CLFAGCHDVLKVYGWEPG-RTLDSIPT GWGKVQDIA------------IAQNQLIGASYHTANI----------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----VLYVCDLKK----------------------------------------IAPLGG VSTSG-----------------------------------------SPFS--HGNSLRKS FS---------R--ERPPGL---KKHT-LDVRTIE-------EVDK--S---------GT DPED------------------------------------------------------ES TY-------ADIPNVTEYHDIFQPNRSLSR---------TPPP--EPEAFEEPQDV--DP TQP-------QILQNFST----SMSSLNI--VDSEEVPPISSPSSSPP----SASTLSLA --KPVPVRVQP------------------------------------------------- ----IKTSPPLQR----NSITTTSQIKANLQA--------------------NNGLGRTS KNLASIPPLRQNITPLPGKKSCPNNDITTL----PQPLGPQRSNSTLTPRVAPMAAVLPV MDDGKLKNRAPSPDSPKHYLKRQNSCRDGEQGYESDYPVQINS-IRHSPSDPALNRPNTA QSRSTSLNRNFATSMS----------------------------------LS-ARNASTA TT--------------------------------FAAKKS--NKAQVAPN---------- ---------LKLEIRASQIRPSIE------------------------------------ ------------------------------------------------------------ -------------------------------------NADKGEFVPISA----------- ------DKP------------------------------------------YGL------ -DVETFL-PNHYAN-PTGLGFS-------------------------------------- -------------QMGVLNEMSEAEVL--------------------------------- ----------------------------------------NSMMRGHESMM--------- -----AVLTSRHR----------------------------------------------- ------------------------SLQIIYSL---------------WHNKDLKAAVESA VAMN-------------------------------------------------------- ------------------DLSVIVDLL-------GILTLKPTMWNLDL-----------C NSL---------------LGPIGD------------------------------------ -----------------------------------------LLQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------KYEMYIT-------- ---VGCSAL-----RLILRN-------------------------------FASVIKSN- -------------V----------------EAPLHT------------------------ --------------------IGVDVSREERYH---------------------------- -------KCLSC------------------------------------------------ -------------------FEKLSTI--------------------------RGILLK-- ---------------------------------------KQGTP---------------- ----G-KLGVL--------------FR---ELAVLIRSI--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------E- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >beetle_outgroup_katnb1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------M-- ------------------------------------------------------------ ----------------------------AHD----------------------------- ------------------------AKVNCLSLGHKSG----------RVMVTGGDD---- ----------------------------------------MKVNLWA------------- ------------------------------------------IGKHTCFM---------- -------------ILSGHT----TPIECVQFNQFEELVCAGSR----------------- -------------------------AGALKVWDLEAAKLVRTLNGHKSALKC-------- ----------------VDFHPY--GDFLASGSSDCSIKMWDSRK--KGCIYTYNGHKATI NSLKFSPDGHWIASGGDDATVKIWDLRVGK--------------VLKDFGEHLNSV-TCV EFHPHE----------------------------------FLLASGSADRSVQFYDL--- --ENFSVVSSE---RD--LGLVRCLCFNPDGE-RLFVGLRDYLKVVGWEPN-RLFDSVMV NWSGVADIS------------IAQNQLVGASFHLTNV----------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----QVYVVDLNK----------------------------------------VHPLNS STETP----------------------------------------PSPFT--PNQSIRKS FS---------K-AERPVSL---KNRS-LDVKTIE-------ES----T---------SG TDPE------------------------------------------------------EE ST-------AEVTNLTDYNEIFKGRG-LTR---------TPPPLEQPEPFQRPEHDYSDP TEP-------QILAEIPTDNFEALSLDNNINCYS--PPPAFTSSQYSR----SKSNLDQV ------------------------------------------------------------ ---------------------YVSRLTKQQDR--------------------ENNISNIN KN---------------------KNQLTTP------------------------------ ----------------RYYLQRQSSCKDVPE----NAPKANNSIIKHSVSD-----ANIS KSSISSRNSSRKNSFS----------------------------------RP-SRNSTSV PN--------------------------------VSKIPSARNSEKVAP----------- --------------VKTYITPTPEDV---------------------------------- ---------------------------FVSSKLSPD------------------------ ------------------------------------SPSEEVEFVPMSM----------- ------DRP------------------------------------------AGL------ -DLDDFL-PKNHRT-LG------------------------------------------- -------------FEQQLPDMSEAEVL--------------------------------- ----------------------------------------GALVRGHEPMM--------- -----AMLVTRQR----------------------------------------------- ------------------------SLKVVLAQ---------------LRSKDIKTATETA VVMG-------------------------------------------------------- ------------------DLAVLVDLL-------GVFNCKYTLWNLDL-----------C VLI---------------LPKIQE------------------------------------ -----------------------------------------LLQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------KFETYVT-------- ---TGCNTL-----KLILKH-------------------------------FGPVIKSN- -------------V----------------QSPVGS------------------------ --------------------FGVDIPREERYN---------------------------- -------KSVKC------------------------------------------------ -------------------HEVLQNL--------------------------RTFLVK-- ---------------------------------------KQSMP---------------- ----G-SVGST--------------FR---EISTLIQNTF-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------D- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >mite_outgroup_katnb1 ------------------------------------------------------------ ------------------------------------------------------------ -----M-------AC--------AARRA----------------------TK------VH E--------F-----------------------------------------------V-- ------------------------------------------------------------ ----------------------------AHG----------------------------- ------------------------AVVNCISIGRKSG----------KVVATAGDD---- ----------------------------------------KKINLWT------------- ------------------------------------------IPRYNCVL---------- -------------RLHGHT----TPIDTVKFHPNEDLLASGSN----------------- -------------------------SGAVKLFDLEAARVLRTLNGHKASVQC-------- ----------------IDFHPY--GEFIASGSCDNSIKLWDSRR--RSCINTYRGHEQKV NSIRFSPDGRWIVSGGDDGSIKLWDLAMGK--------------MLTQFNEHQAPV-SDV EFHPNE----------------------------------YLLASGSEDGSVKFYDL--- --ETWNLISSTS--GD--SGQVHCTRFHPDGD-VIMVGADDLMRVYGWEPTVNTFDRVVM GWGRVEDLM------------VGKEAIVAASKSVTNV----------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----CVYVLDTNK----------------------------------------VQPFAG STT----------------------------------------FIDEVPM--KTTSFRRS SP---------L-GSNPRRS-FNTKTR-GKLDVAY-------KREINSS---------EA SDNS------------------------------------------------------YD SYEPSSTDDVCIMEPSSYNEIFHPSKELSR---------SPPR--DSYPVMSNSGS---- ----------------------GLFR----------LPPIKDAAPN------SIATTTPV --GPSRSPP--------------------------------------------------- --------------------RVDPVISRNLQS--------------------SDCLKSIT AG--------------------NKNSVNSTTTTAMNNFNNTVSNT--------------- ----------------------NNTSNKGNTAY-------STSNMRSSYSM-----GNIK E-TTQHHGSLSSSSST----------------------------------LSSVSDNNRK TG--------------------------------TANSTSSGDLSPILP----------- --------------VSEPSTPVKTQN---------------------------------- ---------------------------FLPRRTAEKTSSEQSLVSIVKPV---------- ------MSVKAAA----------------------VVHPEVVTNIPPAV----------- ------CQPGKQGYNT------ESVGSNGTCGGGG-----------GGIGGGGL------ -NFDDFL-PAHVQS-LSR------------------------------------------ -------------GPRSSVPISETEAI--------------------------------- ----------------------------------------EKISAGHNGMM--------- -----VAMMHRLN----------------------------------------------- ------------------------GLRQIHAR---------------WNPKDPRAAVEVA LNLR-------------------------------------------------------- ------------------DASVLVDLL-------NVLVLRSAMWNLDL-----------C HLL---------------LPAMYE------------------------------------ -----------------------------------------LIQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------KYEPQMA-------- ---TAISGI-----KLVLKN-------------------------------FGTIIKDT- -------------V----------------AGPRS------------------------- --------------------VGVDLSREERYG---------------------------- -------KCSGC------------------------------------------------ -------------------HESLMTI--------------------------RSFLLK-- ---------------------------------------RQTMQ---------------- ----G-KVGSQ--------------FR---DLLAVMEML--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------D- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >slug_outgroup1 ------------------------------------------------------------ ------------------------------------------------------------ -----M-----------------ESKKA----------------------WK------LK D--------F-----------------------------------------------T-- ------------------------------------------------------------ ----------------------------AHS----------------------------- ------------------------ADVKCLGLGHKSG----------RVMVTGGDD---- ----------------------------------------RKVNLWS------------- ------------------------------------------VGKPQCIM---------- -------------SLIGHT----TSIESVRFNPNEELVVAGSF----------------- -------------------------SGALKIWDLEGAKSLRTLTGHKAGIKA-------- ----------------LDFHPY--GNYIASGSMDCNVKLWDVRR--KGCIYTYKSHKDAV NCLRFTPDGLWIASASEDNTVKIWDLTAGK--------------LLSELKDHTGPV-NIV EFHPSD----------------------------------LLLASGSTDRTVKFWDL--- --ESFKCICSSD--TD--RNPVKSIYFHPDGS-CLYSATGFSLKVYGWEPF-VCHEVVPA AWSDIADMA------------VANSQLIASSYNKTNV----------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----SSYVVDLKQ----------------------------------------VAPTGT DGKSD-----------------------------------------SLRA--GMNSSRRS FI---------T--ERPPTS-CSAEPSEPKRSNTP-------PEKN------------ES NEDD-----------------------------------------------------GSL SR-------AEIQNQDEYHKLYAGRANAKN---------------KAEPFRPPFED--DY TDPVKA------------------------------------------------------ --SPSVRKE--------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------VSPR---------- --------------------------------------------VRHSP----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QEPVREPPKE----------------------------------- ------------------------------------------------------------ --------------------------------------------TPQAK----------- ---------------------------------------------------DSV------ -LAEDFL-PKQKPS-ASG------------------------------------------ -----------------SNNVSEGELV--------------------------------- ----------------------------------------EVLTKGHSTMV--------- -----AVLQQRSR----------------------------------------------- ------------------------NLQIVRTM---------------WTSGNTKSAVDSA INMK-------------------------------------------------------- ------------------DKAVLVDLL-------NIINSRASLWNLDL-----------C NLL---------------LPELKD------------------------------------ -----------------------------------------LLCS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------KYESHIT-------- ---TAANAV-----KLVLRN-------------------------------FGNVIKSN- -------------M----------------EEPPS------------------------- --------------------SFVDISREERHK---------------------------- -------KCLAC------------------------------------------------ -------------------YTVLSSI--------------------------KSLIRS-- ---------------------------------------SQSTT---------------- ----TPKVASD--------------FR---EIMILLSGI--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------E- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >amphioxus_outgroup1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------A--------ATKRA----------------------WK------LQ E--------F-----------------------------------------------V-- ------------------------------------------------------------ ----------------------------AHG----------------------------- ------------------------SNVNCLALGYKSG----------RVMVTGGED---- ----------------------------------------KKVNMWA------------- ------------------------------------------VGKPNCIM---------- -------------SLSGHT----SPVECVRFGNAEELVVAGSQ----------------- -------------------------SGSLKIWDLEAAKIVRTLTGHKSNIRS-------- ----------------LDFHPY--GEFVASGSMDTNIKLWDVRR--KGCIFTYKGHTDAV NCIRFSPDGRWIASAGEDSSLKMWDLTAGK--------------MIQEFKDHTGPV-TGV EFHPNE----------------------------------FLLASGSADRTVKFWDL--- --ETFQLVSSTG--AE--SGAIRCIFFHPDGK-CLFGGSQDALRVFAWEPG-RCLDAFSM GWGKVADIS------------VASSQLIGASFSQTNV----------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----SVYIVDLNV---------------------------------------------- ------------------------------------------------------TSGRRT FI---------T--ERPPTS-STKKA--SEMKTEP-------EEEP--T---------AS NEPE------------------------------------------------------DD SSN-----VAQIENPDDYREVFQGRTKIGQLISLC--CLSEPPQGNLSPS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------RPHRK------------------------------------ ------------------------------------------------------------ ------------------------------------EPVKPATIVPADR----------- ------NKP------------------------------------------ADL------ -NLAEFL-PKRPDS-AVSADPR-------------------------------------- -------------RPPAVQEQSEEEVL--------------------------------- ----------------------------------------SSVHKGHESMC--------- -----AVLGNRHR----------------------------------------------- ------------------------NLEIVRAL---------------WTSGDIKTSVDSA VGMK-------------------------------------------------------- ------------------DLSVMVDLL-------NVLILKHSLWTLDL-----------C TVL---------------LPQIQE------------------------------------ -----------------------------------------LLSS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------KYESYCH-------- ---TACNAL-----KIVLRS-------------------------------FSSIIKTN- -------------V----------------QAPPAG------------------------ --------------------GGVDISREERYK---------------------------- -------KCKVC------------------------------------------------ -------------------HGHLMSI--------------------------RGLVEK-- ---------------------------------------KQSMS---------------- ----G-KLGST--------------FR---ELQIMLNGL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DD ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >lizard_outgroup1 M----------------------------------------------------------- ------------------------------------------------------------ -----MAT----AAV--------ATKTA----------------------WK------LQ E--------I-----------------------------------------------T-- ------------------------------------------------------------ ----------------------------AHS----------------------------- ------------------------SSVSSLVLGKSSG----------RLLATGGED---- ----------------------------------------CRVNIWS------------- ------------------------------------------VNKPNCIM---------- -------------SLTGHT----TPVESVKINTNEELIVAGSQ----------------- -------------------------SGSIRIWDLEAAKILRTLMGHKANICS-------- ----------------LDFHPF--GGFVASGSMDTNIKLWDVRR--KGCVFRYKGHSQAV RCLRFSPDGKWLASSSDDHTVKLWDLAAGK--------------IMFEFAGHTGPV-NMV EFHPNE----------------------------------YLLASGSSDRMIRFWDL--- --EKFQVVSCIE--EE--ATPARCVLFNPDGC-CLFAGCQDALRVYGWEPE-RCFDVVPV SWSKVADLS------------ICNNQLIGVSFSQSVV----------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----SSFVVDLNR----------------------------------------VTRSGS GLQGLIRD-------------DRPPA-------------------QQLPP--TGSSLRRI Y-------------ERPSTA-CSKPQR-VKHNSES-------ERRSPSS---------ED DREE------------------------------------------------------KE ST-------AEIQNPEDYQEIFQPKNSITR---------TPPH--KSEPFPAPPEDEPPP VAKEAS------------------------------------------------------ --KPSQTAD--------------------------------------------------- ------LLAPLPS----QENNPEPVQRPPLAS--------------------STPLARTE P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SAVIPAAR----------- ------NEP------------------------------------------IGL------ -KASDFL-PAVKNQ---------------------------------------------- ----------------SLAEIVDEEAV--------------------------------- ----------------------------------------SQIRKGHDTMC--------- -----VVLTSRHK----------------------------------------------- ------------------------NLDTVRAV---------------WNTGDIKTSVDSA VAIN-------------------------------------------------------- ------------------DLSVVVDLL-------NIVNQKASLWKLDL-----------C TVI---------------LPQIEK------------------------------------ -----------------------------------------LLQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------KYESYVQ-------- ---TGCTSL-----KLILQR-------------------------------FLPLITDI- -------------L----------------AAPPS------------------------- --------------------VGVDISREERLH---------------------------- -------KCRLC------------------------------------------------ -------------------YKQLKNI--------------------------SNVIKN-- ---------------------------------------KSGLS---------------- ----G-RHGSA--------------FR---ELHLLMAVL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------E- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >Oikopleura_outgroup1_O_dioica ------------------------------------------------------------ ------------------------------------------------------------ -----M------------------NEEG----------------------IT------RT Q--------F-----------------------------------------------I-- ------------------------------------------------------------ ----------------------------PHS----------------------------- ------------------------APISALKFGNDAS---------KCMLATCGED---- ----------------------------------------RKLKIWD------------- ------------------------------------------VSRA-------------- -G-----------QTAAHSFDLVSTGSGLNFNSEDSKVTTGLQ----------------- -------------------------NGTIKLWDLESCKDFRVLSGHRAEVTC-------- ----------------VEHYEYHKSNYLASASMATDIKMWDIRK--KGVLLTYGEHEAAV SCIRFSPDGRSMLSSDRDGIVKVWDLRSGK--------------SVATKSDAAGEI-TDL QFHPSE----------------------------------MLFAASSQDGRCYFYDF--- --ENYQLVSHTE--KS--TNIPSAIRFTFAGD-VLTALMGDLLAEFAWEPEARRTKAIHI NNGKKGDLM------------LSQNKSIATGIKEKNQL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----IINIVDSSK----------------------------------------IKHKSQ NRKQS----------------YSTPKLGKAN--------------QSLPD---------- -------PNISSISERPRNV---------------------RPASINMN---------HS NSKE------------------------------------------------------QN SSLPV----AKSVGQHA----FNSAHKLPR---------SPRA----------------- -------------------------------------------------------VKAPS --KPRARDV--------------------------------------------------- ---------------------------------------------------KADLMSRMK QR--------------------NENDIPVEI----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------HVAPAPVH----------------------------------- ------------------------------------------------------------ -----------------------------------KSKRPLAMVKPNNSM---------- -EID-------------------------------------------------------- --------PSLLAS---------------------------------------------- -------------PVQAQKTLQEPSHI--------------------------------- ----------------------------------------LELLEHSVEVK--------- -----KVLKNRHL----------------------------------------------- ---------------------------ILEDC---------------FRNQPMIESLRKS YR---------------------------------------------------------- ------------------DRGVMYDIL-------SSILAMPDIWTLEL-----------A VEA---------------TQVASL------------------------------------ -----------------------------------------LAQS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------TEEHHQK-------- ---LSTVAL-----KHILTA-------------------------------YRQTIENS- -----------------L------------NTPMG------------------------- --------------------IGVDLTAEKRQQ---------------------------- -------RS--------------------------------------------------- ----------------------------------------------------KEILRL-- ------------VDATRN--------------------------------AFQPSSQN-- --------ATT--------------LK---EIDFLMRNF--------------------- --------------------------RAS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >Hemicordata_outgroup1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------A--------ATKRA----------------------WK------LQ D--------F-----------------------------------------------V-- ------------------------------------------------------------ ----------------------------AHS----------------------------- ------------------------ANVNCLALGPKSG----------RVMVTGGED---- ----------------------------------------KKVNMWA------------- ------------------------------------------VGKPNCIM---------- -------------SLSGHT----SPVESVRFGNTEELVAAGSQ----------------- -------------------------SGTIKIWDLEAAKIVRTLTGHKSSIQT-------- ----------------LDFHPY--GEFVASGSFDTNVKLWDVRR--KGCIYTYRGHTNRI NSVRFSPDGRWVASAGEDGLAKLWDLAAGK--------------LINEFKHHTGPV-NNI EFHPNE----------------------------------FLLATGSADRTVKFWDL--- --ENFNLVGTTD--KE--ASPIRCILFHQDGN-VLFSGGQDSLHVYSWEPV-KCFDSYSM GWGKVADMT------------TSSNQLIGASYSQSNV----------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----SLFVVDLAR----------------------------------------TNMSGD ISHVE-QP-------------SKPVQ-------------------QQIPF--TASGHRKN FV---------T--ERPHTQ-CSGGDQGAEMKTEP-------EEEQ--T---------QD HGED------------------------------------------------------DQ SP-------AQIENPDDYRELFQPRKHLAR---------SPPK----EPFPAPLAD---- ------------------------------------PVPVAVVPANNQQNVT-------- --RPVTQSV--------------------------------------------------- --------------------SRPVTQSVSQTH--------------------SSP-PRQE PE-------------------------------------------------APVHQP--- ------PPAAP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------VHQPPPAAQ------------------------------------ ------------------------------------------------------------ -------------------------------------HHPVSNVIPSDR----------- ------DKP------------------------------------------VGL------ -DMNAFL-PKQPQH-SVAPSSSVNN----------------------------------- -------------ANIGPPEVSESEII--------------------------------- ----------------------------------------SAIEKGHGSMC--------- -----SVLTSRHK----------------------------------------------- ------------------------NLDVVRSI---------------WTSGEIRTALESA INMN-------------------------------------------------------- ------------------DLAIIVDLL-------NVMCLKTSLWKLDL-----------C VVL---------------LPKIEE------------------------------------ -----------------------------------------LVES--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------KYENYIL-------- ---TSCQAI-----KLIMKS-------------------------------FSQLIKSN- -------------I----------------TSPPL------------------------- --------------------SGVDISREERYN---------------------------- -------KCKKC------------------------------------------------ -------------------YDSLVNI--------------------------RYIIEQ-- ---------------------------------------KQHLV---------------- ----G-KIGST--------------FR---EVKLILGGL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >Ciona_outgroup1 ------------------------------------------------------------ ------------------------------------------------------------ -----M-------AS--------STKTT----------------------WK------LQ E--------F-----------------------------------------------V-- ------------------------------------------------------------ ----------------------------GHG----------------------------- ------------------------SVVTSATLGKKSG----------RVMATGGED---- ----------------------------------------GKVNMWH------------- ------------------------------------------VGSPNCIM---------- -------------TLSPLT----SAVETLQFNSSEEFVCAGSR----------------- -------------------------SGALRIWNLSASKVVRQLTGHKAAVRS-------- ----------------VDFHSY--GDFVTSGSDDHKVRMWDIRR--KGCIFTYKGHEDSV NCVQFSPDGRWIGSVSNDKTCKLWDITAGK--------------LLHELNDHSAGV-TCL TFHPRE----------------------------------LLLATGSTDRTTNIYDV--- --ERFKLLSTSP--LE--ANGIRKIMFSESGD-QIYTASQDMFKTYTYDPMCYHLDSVIV KWGKPADIT------------ISGEKLMGCSFYQNIV----------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----YVHIIDLKT----------------------------------------LQTSPT HESESIKF-------------------------------------EAKPN--QPSSRSHS NV---------T--TRPHTT-CGVPAK-FPPNPPQ---------------------VVQC NNNN------------------------------------------------------SE ST-------FKQINPQAKDEIFKPTSTLAR---------SPDK--DNNATKDQTKD---- ------------------------------------------------------------ ------------------------------------------------------------ --------------------KTNPTNTTNLHE---------------------------- ----------------------NQRKLNIDET---------------------------- ---------------PASNVQPTAQEPKKPN----NAVTNTPDVTPAPHAQ-----HNNE PSTILNWDKLQSCDQN----------------------------------IP------EK PG--------------------------------ACNLLTNNDSKKIFQ----------- --------------QKPNALPTKSA----------------------------------- ------------------------------------------------------------ ------------------------------------SDLGISTVIPSDR----------- ------QDP------------------------------------------IGL------ -DMNAFL-PAKKDK---------------------------------------------- -------------PSMFCATKTDHEVV--------------------------------- ----------------------------------------TTITKGVSSMR--------- -----MVLTNRHK----------------------------------------------- ------------------------NLEIVRAL---------------WTTGDVMTSINSA VKMD-------------------------------------------------------- ------------------DQALIVDLL-------NVLTLKPSLWTLDL-----------C VVM---------------LPQIKS------------------------------------ -----------------------------------------LISS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------KYETYVS-------- ---VGCSAL-----KLILKN-------------------------------FSQVIRSN- -------------L----------------KTPPT------------------------- ---------------------VVDISREERHK---------------------------- -------KSKSC------------------------------------------------ -------------------YSYLADI--------------------------RVLLDS-- ---------------------------------------KQQTA---------------- ----G-KIGSQ--------------FR---ELKILISTL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------E- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >zebrafish_outgroup2 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------A-------------------------------------------TE EKKPD------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TEATKTQPAS----------------------- -----------------------------------------------------------A ASASQSKS-------------------------------APVKPNYTLKF---------- -------------TLAGHT----KAVSSVKFSPSGEWLASSSADKLIKIWGAYDGKFEKT ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC-------- ----------------CNFNPQ--SNLIVSGSFDESVRIWDVKT--GKCLKTLPAHSDPV SAVHFNRDGSLIVSSSYDGLCRIWDTASGQ------------------------------ ------------------------------------------------------------ ------CLKTLI-DDD--NPPVSFVKFSPNGK-YILAAT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LD NT---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LKLWDYSK------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GKCLKTYTG------------------------------ -HKNEKY----------------------------------------------------- ------------------------------------------------------------ --------------------------------CI-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------FAN------ ------------------------------FSVTGGK----------------------- -----------------------------------------WIV---------------- ----------------SGS----------------------------------------- ------------------EDNMVYIW-------NLQT---------------KEIVQK-- ------------LQGHTD---------------------VVIST------ACHPTENI-- -IASAALENDK-------------------TIKLWKSDC--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >amphioxus_outgroup2 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------S-------------------------------------------AE KKEPE------------------------------------------------EAP-V-- ------------------------------------------------------------ ----------------------------APK-PAAP------------------------ -------------------TTTASQPTPATTATTTTT----------------------- -----------------------------------------------------------S TQNTQPKP-------------------------------QPLKPNYTLKF---------- -------------TLAGHT----KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT ISGHKLGISDVAWSSDSHLLVSASDDKTLKIWDLNSGKCLKTLKGHSNYVFC-------- ----------------CNFNPQ--SNLIVSGSFDESVRIWDVKT--GKCLKTLPAHSDPV SAVHFNRDGSLIVSSSYDGLCRIWDTASGQ------------------------------ ------------------------------------------------------------ ------CLKTLI-DDD--NPPVSFVKFSPNGK-YILAAT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LD NT---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LKLWDYSK------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GKCLKTYTG------------------------------ -HKNEKY----------------------------------------------------- ------------------------------------------------------------ --------------------------------CI-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------FAN------ ------------------------------FSVTGGK----------------------- -----------------------------------------WIV---------------- ----------------SGS----------------------------------------- ------------------EDNMVFIW-------NLQT---------------KEVVQK-- ------------LQGHTD---------------------VVLCT------ACHPTENI-- -IASAALENDK-------------------TIKLWRSDV--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >bumblebee_outgroup2_B_impatiens ------------------------------------------------------------ ------------------------------------------------------------ -----M--------V-------------------------------------------PL GPSPG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------HQTSVNNTPTTPASGTK----------------------- -----------------------------------------------------------S SST--------------------------------------LKPNYTLKY---------- -------------TLAGHT----KAVSSVKFSPNGEWLASSSADKLIKIWGSYDGKFEKT ISGHKLGISDVAWSSDSRLLVSASDDKTLKIWELSSGKCLKTLKGHSNYVFC-------- ----------------CNFNPQ--SNLIVSGSFDESVRIWDVRT--GKCLKTLPAHSDPV SAVHFNRDGSLIVSSSYDGLCRIWDTASGQ------------------------------ ------------------------------------------------------------ ------CLKTLI-DDD--NPPVSFVKFSPNGK-YILAAT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LD NT---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LKLWDYSK------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GKCLKTYTG------------------------------ -HKNEKY----------------------------------------------------- ------------------------------------------------------------ --------------------------------CI-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------FAN------ ------------------------------FSVTGGK----------------------- -----------------------------------------WIV---------------- ----------------SGS----------------------------------------- ------------------EDNMVYIW-------NLQT---------------KEIVQK-- ------------LQGHTD---------------------VVLCT------TCHPTDNI-- -IASAALENDK-------------------TIKLWKSDT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >limpet_outgroup2 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------S-------------------------------------------EE TAVPK------------------------------------------------TES-V-- ------------------------------------------------------------ ----------------------------ESK--PLP------------------------ -------------------TSTITATTPSTVSAAPVT----------------------- -----------------------------------------------------------S NTTTQSKPQ-----------------------------SQPQKPNYTLKF---------- -------------TLAGHT----KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT ISGHKLGISDVAWSTDSRLLVSASDDKTLKIWDFSMGKCLKTLKGHSNYVFC-------- ----------------CNFNPQ--SNLIVSGSFDESVRIWDVKT--GKCLKTLPAHSDPV TAVHFNRDGSLIVSSSYDGLCRIWDTASGQ------------------------------ ------------------------------------------------------------ ------CLKTLI-DDD--NPPVSFVKFSPNGK-YILAAT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LD NT---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LKLWDYSK------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GKCLKTYVG------------------------------ -HKNEKY----------------------------------------------------- ------------------------------------------------------------ --------------------------------CI-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------FAN------ ------------------------------FSVTGGK----------------------- -----------------------------------------WIV---------------- ----------------SGS----------------------------------------- ------------------EDNVVFIW-------NLQT---------------KEIVQK-- ------------LQGHTD---------------------VVLCC------ACHPTENI-- -IASAALENDK-------------------TIKLWRSDV--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >lizard_outgroup2 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------A-------------------------------------------TE EKKPD------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AESTKTQSTP----------------------- -----------------------------------------------------------S SSTNQTKT-------------------------------APVKPNYALKF---------- -------------TLAGHT----KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC-------- ----------------CNFNPQ--SNLIVSGSFDESVRIWDVKT--GKCLKTLPAHSDPV SAVHFNRDGSLIVSSSYDGLCRIWDTASGQ------------------------------ ------------------------------------------------------------ ------CLKTLI-DDD--NPPVSFVKFSPNGK-YILAAT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LD NT---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LKLWDYSK------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GKCLKTYTG------------------------------ -HKNEKY----------------------------------------------------- ------------------------------------------------------------ --------------------------------CI-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------FAN------ ------------------------------FSVTGGK----------------------- -----------------------------------------WIV---------------- ----------------SGS----------------------------------------- ------------------EDNLVYIW-------NLQT---------------KEIVQK-- ------------LQGHTD---------------------VVIST------ACHPTDNI-- -IASAALENDK-------------------TIKLWKSDC--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >Oikopleura_outgroup2_O_dioica ------------------------------------------------------------ ------------------------------------------------------------ -----M------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SAPTPAAKPA----------------------- -----------------------------------------------------------S KHT--------------------------------------PPPNYKCVL---------- -------------SLKGHT----KAISCVKFSEDGLWLASASADRTIRIWNAYDGNIEAV IAGHKLGISEIAWSNDSTLLCSASDDKTVKIWDVGTRKCLKTLKGHTNYVLC-------- ----------------CGFNPQ--SSLIVSGSFDESVRIWDVKT--GMALKCLPAHSDPV SAVHFNRDGSLIVSSSYDGLCRIWCTSTGQ------------------------------ ------------------------------------------------------------ ------CLKTLI-DNDPTNPPVSYVKFSPNGK-YILAAT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LD NT---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LKLWDYSK------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GRCLKQYSG------------------------------ -HQNKKY----------------------------------------------------- ------------------------------------------------------------ --------------------------------CI-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------FAN------ ------------------------------FSVTGGK----------------------- -----------------------------------------WIV---------------- ----------------SGS----------------------------------------- ------------------EDHKVYLW-------NLQT---------------KEIVQK-- ------------LEGHED---------------------VVICT------AVHPNQNM-- -IASGGLEGDK-------------------LVKIWKSDN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >Hemicordata_outgroup2 ------------------------------------------------------------ ------------------------------------------------------------ -----M-------AS-------------------------------------------TE DNKPG---------------------------------------------------GV-- ------------------------------------------------------------ ----------------------------QQNKPPPP------------------------ ---QPVATSQR-----STTPSGTTTNTTTTTTATTTP----------------------- -----------------------------------------------------------S SNTNL----------------------------------TGKRPNYTLKF---------- -------------TLAGHT----KAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT ITGHKLGISDVAWSSDSRLLVSASDDKTLKIWELNSGKCLKSLKGHSNYVFC-------- ----------------CNFNPQ--SNLIVSGSFDESVRIWDVKT--GKCLKTLPAHSDPV SAVDFNRDGSLIVSSSYDGLCRIWDTASGQ------------------------------ ------------------------------------------------------------ ------CLKTLI------------------GK-FILLLY--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------IN RT---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------ILI----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------LVQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >seaUrchin_outgroup2 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------S------------------------------------------CTE DIKPC-------------------------------------------------AGGD-- ------------------------------------------------------------ ----------------------------AKAATVKP------------------------ -------------------------QTTPTITSASSA----------------------- -----------------------------------------------------------A AACN-----------------------------------LPKRPNYSLKF---------- -------------TLAGHT----KAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT ISGHKL------------------------------------------------------ -------------------------------------------------MKLLPGERFTK TRIDFKLDPTM---SKFHKECS-------------------------------------- ------------------------------------------------------------ --------------------PPSFQFFTI------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ST---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LKLWDYSK------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GKCLKTYTG------------------------------ -HKNEKY----------------------------------------------------- ------------------------------------------------------------ --------------------------------CI-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------FAN------ ------------------------------FSVTGGK----------------------- -----------------------------------------WIV---------------- ----------------SGS----------------------------------------- ------------------EDNMVYIW-------NLQT---------------KEIVQK-- ------------LQGHTD---------------------VVLCT------SCHPTENL-- -IASAALENDK-------------------TIKIWRSDC--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >PtAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------S-SIPDYHRTTNNA----------------------WNP-FRPVLN Q----------------------------------------------------R-EPD-- ------------------------------------------------------------ ----------------------------EKP-WEAP----SKETMKTRQD----FRESVF ---RETPDHRRIHPHGGLGDTG--RNILYVLHDRQCYGFHGLTRQRHILQ---GEAERKR DSPSTVFD---------------------------SPVSTTATSLYTSASTERA-----R SDNSLAHEGSSDGMNTKFDVDQKQHLERRVSYPRRLIQEVRTFAEY-CSAVKSHSAFLMH LGGGDEIDEDGNRPQSSTA----VSTISVAFSPDGKTMGSTHG----------------- -------------------------DHTVKISCCHTGRLLQSLEGHPRTPWT-------- ----------------VKYHPSD-SRIVASGCLGYQVRIWNWKE--RACLQMVRLE-FAI ISISFHPTANILAIANGSR-LHFWGIKE------------------------QAQT---- -----------------------------------------PLSSPAGTRTAQPIDR--- S-SLLTEFDQ--------RHMLRCVHFPPGGR-SIIIGG--------------------- ----VNTIN------------EDPRRRNRGGIGGGG--------------------LSFY LRMWDF------------------------------------------------------ -----------------------------------DPD---------------------- -----VALQGS------------------------------------------------- ---------------------GALSVMAG------------------------------- -------------IAIP-----------KRAIGNPRLFV--PRALLY------------- NDGG------FDVSPDGKTLCACAELWL------------------------------PD GV---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------DNAMELL-----Q------------------------ ----------------------EEQ----------------------------------- --RA-YEVELGESERS-------------------------------------------- ------------------------------------------------R----------- -------------HELAASDPNGS------------------------------------ ------------------------------------------------------------ -----------------------------------------QSTVP-------------- ------AAAVFEG------------------------------LTTCNVPSIGT------ --------PSLAAT-SSGPR------------------------------------TPKL PR-------TPTRDSVSDTLPASQEYI--------------------------------- ------------------------------------------------------------ ----PRTPENPREVPRNGGLSPPS--------------------------------PPGR RFT--------------------------------------------------------- --------------------------------GVF---------------H--------- ------------------------------------------------------------ ------------------QPREIV----------------------------S------- -------------------------------------------TS--------------- ---------GQ-QPVSDIRSSIRGLATPSA-----------------------P------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------TP---------------------------------------- ----------------------PAP------GGPGSRP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------LHPLSV------------------------- ------------------------------------------------------------ --------------------QQV------------------------------------R RGK--------------------------------------------------------- --------------SLGPVA-------------------------KGYLPRMGQLLEACP LDGAKASAVTCVK-----------------FSPSAD------------------------ ---------------------FCLIGYGVREP---------VVE---------------- ------------------------------------------------------------ -----------GGCHF---HPVTALY-------RIRGG--------------MTHVST-- ------------MLSSDD---------------------DVNIA------RFHPDSGH-- ----GFVYGTK----------------QG-RVRVLSPRP--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------WMFYTC--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >PinfAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M-------DS-KV--------------------------------WQ-------- -----------------------------------------------------RAAAD-- ------------------------------------------------------------ ----------------------------LNP-PGVP------------------------ ----NSFRHAK---------NQ--QNIASVLLRREFG-GS-RRQKTVRAI---GED---- ----------------------------------------KEESFW-------------A ESESSAKH----------------------------------QSRY-F------------ -------------ELPQTT----KSTISIAISPDGKTFASTHG----------------- -------------------------DHTVKIICIETGKVIQTLVGHPRTPWS-------- ----------------VKFHPTD-PRYVASGCLGFQVRFWDIET--GRCLYVSTLR-HAI ISISFHPSGDILAIASGTC-VYTWDYQH-------------------------------- ------------------------------------------------------------ T-CPRIAMFS--------YQTLRSVTFLPDPS-KIMVGE--------------------- ----ANERY------------VRPQGQAPPSDLTVTLT---------------------- --MWDF------------------------------------------------------ -----------------------------------DPS---------------------- -----WALSPE------------------------------------------------- ------------------------------------------------------------ ----------------PLLT--------KKAMNNSRVIL--SHALIY------------- NDGG------FDISRCGRYLAICADFSL--------RQ--------------------AE KE-------------------VEME----------------------------------- -------------------------------AENEAATDLE--------------SILSS --VPATQET--------------------------------------------------- -------------------------TAGGATS---------------------------- ---------------------PSDDVNDVS----------------VS------------ ----------------------NPQ----------------------------------- --AT-TLNESSSSSGAAARTTR-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GNGVAPQTLP--------TTMPLS LPIH-PPPPRLVP---------------------------------FSGMHTGA------ --------PNMLAA---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------LQSAAADL---------SLTMDQYM--------NQQIRRVRP RLH---------------PPHSIH------------------------------------ ------------------------------------------------------------ ------------RYTAAMEP-ARSTAAPAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------VP---------------------------------------- ----------------------QQRYS--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QIRPNIALSRT------------------ --RF-------------------------------------------------------- ------------------------------------------------------------ -------------------TRNQRNRR---GRLSS------------------------- ------------------------------------------------------------ --------------------ENQ------------------------------------- ---------------------------------------------STWLALI-------- --------------SLDPEQ-------------------------------LGRVVQTCH LAETAAGGVTSVK-----------------ISPTSA------------------------ ---------------------YVLLGYGVRDR---------------------------- I---------------QRE----------------------------------------- -----------TEFPV---HRVTRIY-------RWED---------------MALLSH-- ------------VESAMD---------------------DVNIALKVNCECVAPSAAT-- ----STTRRTV----------------TSWMVRVVVITI--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------KM------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >AaAMBRA1 MKMD-------------------------------------------------------- ------------------------------------------------------------ -----M--------S-PSPRSV-TTKAS------------------------------LE DDDDR----M-------------------------------------------QCDDE-- ------------------------------------------------------------ ----------------------------EEA-PGTP-------------EM--------- ------------------------PSFLPSLIIEALGYPA-------------------- -----------------------------------GLGALVVCQAWRQQA-ERIFRRELS ELRCASHC----------------------------------RAEY-L------------ -------------ALPPTT----KSTISVAFSPDLKRFASTHG----------------- -------------------------DHTVKVVDFESGRVAATLVGHPRTPWT-------- ----------------VKFHPFL-PDVVASGCLGFEARVWDARE--RRCVRRAEFD-RAI ISLSFHPAGDILAVAAGTS-IYLWHYATG------------------------------- ------------------------------------------------------------ A-APRREFTH--------PHPIRCLRFLPSRD-AIIVGA--------------------- ----ANNGAN-----------EGDAPRIT-----------------------------FQ LMLCDF------------------------------------------------------ -----------------------------------DVE---------------------- -----AARADA------------------------------------------------- ---------------------GAPAGGGS----------PSSPTSVRGPT--EDAAG--- --------------DPPLLA--PVAGSGRAVSRRPRCVL--RRALFY------------- NDGG------FDVSPCGRFLCSCAELWL--------PYADQDGDAP------------PD GDAP----------------------------------PAPPP--RHPRGDAPPPP---- -------PPRRLAGGAAR-------------AAAAAAWPLPSFSSAAAR-ARARAPAAPA --SPGARPRRDAPLLPWWRVYARGGGARGWLGRGAPRTPPRRRDGDESGDSA-------- --------SPGGR-----DGAVAPADRAGSPG------------------GRQRLKGRYK PHLV---------------VVSLEDAADDG------------------------------ ----------------------EGA--------------------------------LLQ AAALDDHSFSGAAGETAGSDIVTSVK---------------------------------- -----------LSPTASL-------------VLLGHSRGGDGTFGDGVPRVVSVMYRVGD MVRVDTRKEVGDDVNIARFHPVPGA----------------------------------- --GIVYGTKQG---------------RICKMTPAPRTPPGQAAAAPRPAG---------- ----DAPAAQPTAVTMAALLDTSKAADAT---DATDMSGVRVERSPLHGRGLFAARDFAA GETILVEAPLVAMQDLANRHAALVCGECLAFLDLGRDL--------LEAVAAGAS----- --------PRVAAD-AAVARGG-GP-VARCADGCGELYCSAACRDAHRRRCHRALCVGPV AEADA----AADPLVRYKILATESNEI-----LFLAADV--------------------- --------------------------------------VAAALADGAAAAAFLPFTRVPW DRVVADAAALRGDDARDGALLGEA----------------------------------LR RLC-------------------GDAAPLL------------------RDALAARGFANAA DVTPE---------------------WL----ARIVGTFEQNNVGVRLR-HPLDDDDDDE AEDDDDDDDDEDEAEDGGAVARAASLEDVDRLAAAPGAVAVVKFSAAWCAPCRAMAPAFA ALAEALPEARFVAVDVDEVPDAAARFEAGALPTFVLLRDGDELARVEGADERALRAQLAL AGCPPPDDGDADDDATADTDDGDGTDDGGGGAYGMPPLEGTALYS------TICCANHAC DQSCDVLYAAPSEPGGEPGP-GRFGAPLRASLVARRAVAAGDELTIAYVDTDAP------ WQERRAA----------------------------------------------------- --------------LADYGF-----------------LCRCS------------------ -------------------------------RCL-------------------------- --------------EPVALP---------------------------------------- --GAWDALLAFFAPGG------ASE-RYRIALDPSARA---------------------- --------------------------------------AASAARAAAGEATPAFPPRR-- ------AQCVDGALRP-GSWSSSGLAWDDRAAPWWNPEAFALTHGKWSTEVWLPLALARS RAGNERD-ARSRWGARTAAEARDADATVVMYQSRRNDRNALSWCRAKVAASSATWGRDG- GASFWFT----AASSRGGCCDGGQARDPGLLA-----HHFLGH----------------- --------VGEKRHGP-------------------------------------------- ------WLFREARFA----DHLLRPTQYK-APATR------------------------D TAPKI---------------------------------------RCFDER---------- --------------------KDVALP------------------------PPALLLRRRR R-----RARAPGRSGAELL---ALFDADARKETLVMAAEGRAGGLEYDLRRALTDAWDPG GPLRAKRGVARAPPPLDPRVDVRFL--------------------------MAKANYTES MRRAKY-CVVTEG-----------------FSPWSPRLSEAVALGCVPCFLSPSLAPPYA TVLDWSAFSVEIAEADVGRLPEVLAAYDWAYLHA-------NLLR--------------- ------VRPLFAFCVDDGG------EDGCGE----------------------------- -----------GDLPG--DGLPLVVFLM-ATR-RIVAPPPPPEPGADRYDGTATLLAS-- -------AAGGDATADADVLYACSLASGACRYEVRGDEWECAMANKHACMCKKRVAGN-- WTYVGTTTGLK-----------------GNRPRLYHNR---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >EsAMBRA1 ------------------------------------------------------------ ------------------------------------------------------------ -----M--------Q--------------------------------------------- -----------------------------------------------------Q---Q-- ------------------------------------------------------------ ----------------------------QHQQQRRP---------------------RQW -GGPNRPGGRR---------RS--QSLLETLNSRSTS----------------GRP---- ----------------------------------------RGVELW-------------A EDESVFRQ----------------------------------QLEY-L------------ -------DLAAACAGSGPS----RSTIAVAFSTDGKLFASTHG----------------- -------------------------DHTVKITDFFRGRVVQSLQGHPRTPWT-------- ----------------VKFHPKD-ARIVASGCIGSEVRVWNAST--GRCLHSVTLE-AAI ISLSFHPSGKMLAIASSLY-VYLWDYNS------------------------K------- ------------------------------------------------------------ A-RPFIAWAH--------SHTLRCVRFTPGGD-GIIVGA--------------------- ----ANSSS------------SSSSPSSQQSQVT-------------------------- --VWDF------------------------------------------------------ -----------------------------------SLE---------------------- -----AAFAED------------------------------------------------- ------------------------------------------------------------ ------------V---------------SAAMTRERVLL--SRALLY------------- NDGG------FDVSEDGLWLCTIAEL--------------------------------GE RV-------------------VASD----------------------------------- -------------------------------RRSLPAGPSL--------------ASEQS --IPSLASP--------------------------------------------------- -------------------------TGAAATA---------------------------- --------------------SPMSTLTEVE------------------------------ ----------------------EEE----------------------------------- --AG-REGEAVEKGSAAARGGK-------------------------------------- ------------------------------------------------R----------- -------------KGRATTEPPGGA----------------------------------- -----LGSKKG------------------------------------------------- -----------------------------------SGNGVGDTVAP-------KNGSNLG RPCH--AVPALVTTT-------GRVARTE--------------------SLTGS------ --TSAVAAPAAAGA-GSGSGGGTGP-------------------------------AAPA RP-------ESWGQQREARAGKKSDII--------------------------------- --------------------------------------VIINSKKGRG------------ ---GYGSEEERHH----------------------------------------------- ----------------------GDGGDSVRVEGGAA-----GWRRDSPDNNNNSNNASSS SS------------------------------SSS------------------------- ----------------SGSSSSSGGV--------HSSSFRRRC----RASPSLAVESQPP RKL---------------VPHLVM------------------------------------ -------------------------------------------VSL-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------NVE------GGRGGGG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GAERGS-------------------------------VARVVRAEP MDTLNAKQVTSVK-----------------LSPSAR------------------------ ---------------------YILLGVGVRNG---------GLGGGGGGGGGGRATRQTR QQQQERQAAAVP----DRR--------------------------GNAPDA--------- -----------PAIPLPSQRALSSIY-------RSVD---------------LQPVNS-- ----------MPMPTGEE---------------------DVNIA------CFHPEPGM-- ----GCVYGTK----------------QG-RVGLVRMSA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------D-------------- ---------------------