Cimetta, Elisa
(2024)
Verteporfin induces apoptosis and reduces the stem cell-like properties in Neuroblastoma tumour-initiating cells through inhibition of the YAP/TAZ pathway.
[Data Collection]
Collection description
Data and manuscript. We evaluated the pharmacological targeting of YAP/TAZ with the YAP/TAZ-TEAD inhibitor Verteporfin (VP) in Tumour Initiating Cells (TICs) derived from High-Risk Neuroblastoma patients. VP treatment suppresses YAP/TAZ expression, induces apoptosis and causes the re-organization of the cytoskeleton reducing cells migration and clonogenic ability. Moreover, VP reduces the percentage of side population cells and ABC transporters involved in drug resistance, and the percentage of stem cell subpopulations CD133+ and CD44+ of TICs. Finally, we demonstrated that VP sensitizes TICs to the standard drugs used for neuroblastoma therapy etoposide and cis-platin opening the way to use VP as drug repositioning candidate for recurrent neuroblastoma.
| DOI: |
 10.25430/researchdata.cab.unipd.it.00001232 |
| Keywords: |
Neuroblastoma
Verteporfin (VP)
YAP/TAZ
Tumour initiating cells (TICs) |
| Subjects: |
Life Sciences > Physiology, Pathophysiology and Endocrinology: Organ physiology, pathophysiology, endocrinology, metabolism, ageing, tumorigenesis, cardiovascular diseases, metabolic syndromes > Fundamental mechanisms underlying cancer |
| Department: |
Departments > Dipartimento di Ingegneria industriale (DII) |
| Depositing User: |
Elisa Cimetta
|
| Date Deposited: |
18 Mar 2024 13:07 |
| Last Modified: |
18 Mar 2024 13:07 |
| Creators/Authors: |
|
| Type of data: |
Mixed |
| Contributors: |
| Contribution | Name | Email |
|---|
| UNSPECIFIED | Cimetta, Elisa | elisa.cimetta@unipd.it | | UNSPECIFIED | Fusco, Pina | p.fusco@irpcds.org |
|
| Research funder: |
European Commission |
| Research project title: |
MICRONEX |
| Grant number: |
759467 |
| Collection period: |
|
| Resource language: |
English |
| Metadata language: |
English |
| Publisher: |
Research Data Unipd |
| Related publications: |
|
| Date: |
13 March 2024 |
| Copyright holders: |
The Author |
| URI: |
https://researchdata.cab.unipd.it/id/eprint/1232 |
| Creators/Authors: |
|
| Type of data: |
Mixed |
| Contributors: |
| Contribution | Name | Email |
|---|
| UNSPECIFIED | Cimetta, Elisa | elisa.cimetta@unipd.it | | UNSPECIFIED | Fusco, Pina | p.fusco@irpcds.org |
|
| Research funder: |
European Commission |
| Research project title: |
MICRONEX |
| Grant number: |
759467 |
| Collection period: |
|
| Resource language: |
English |
| Metadata language: |
English |
| Publisher: |
Research Data Unipd |
| Related publications: |
|
| Date: |
13 March 2024 |
| Copyright holders: |
The Author |
| Last Modified: |
18 Mar 2024 13:07 |
|
orcid.org/0000-0002-8632-3999
