Ceccato, Filippo and Mondin, Alessandro (2024) PANOMEN-3 grading score is reliable in predicting pituitary adenoma behavior and prognosis: a single center cohort study. [Data Collection]
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PANOMEN-3 grading score is reliable in predicting a pituitary adenoma behavior and prognosis: a single center cohort validation study. (deposited 05 Aug 2024 08:05)
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PANOMEN-3 grading score is reliable in predicting a pituitary adenoma behavior and prognosis: a single center cohort validation study. (deposited 04 Nov 2024 08:23)
- PANOMEN-3 grading score is reliable in predicting pituitary adenoma behavior and prognosis: a single center cohort study. (deposited 26 May 2025 06:54) [Currently Displayed]
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PANOMEN-3 grading score is reliable in predicting a pituitary adenoma behavior and prognosis: a single center cohort validation study. (deposited 04 Nov 2024 08:23)
Collection description
Background Pituitary adenomas (PAs) comprise a heterogeneous group of diseases: a scoring system to guide prognosis and therapy is still missing. Methods We assessed a retrospective single-center cohort of 401 patients with PAs followed over the last two decades using a newly developed Pituitary Society grading system, PANOMEN-3. Results A high initial grade of the adenoma predicted a worse long-term outcome despite multimodal treatments (grade 3, disease remission OR 0.49, 95%CI [0.27; 0.84], p = 0.01). The grade could predict tumor behavior following surgery: a higher grade at baseline predicted relapses after disease remission (grade 3 vs grade 1/2, p = 0.01) and a higher postoperative grade predicted the need for additional treatments in case of persisting disease (grade 2/3 vs grade 1, p = 0.02). A score downgrade obtained with primary medical predicted the reduction of additional interventions and long-term biochemical control. When considering CD patients, both a lower initial grade (grade 2 vs grade 3, p < 0.01) and preoperative eucortisolism (p = 0.04) reduced recurrence risk. Contrarily to the whole-cohort analysis, grade predicted the surgical outcome in non-functioning pituitary adenomas and in acromegaly. Conclusion Our data suggest for the first time that PANOMEN-3 grade system could be useful in everyday clinical practice, aiding physicians in both improving follow-up strategies for patients in remission and in the management of persisting disease for all pituitary adenomas. Especially for CD, a high initial grade could encourage clinicians to institute preoperative medical treatment and to adopt a closer follow-up schedule in cured cases.
| DOI: |  10.25430/researchdata.cab.unipd.it.00001343 |
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| Keywords: | PANOMEN-3, pituitary adenoma, grading system, nonfunctioning pituitary adenoma, Cushing’s disease, acromegaly, prolactinomas. | |||||||||
| Subjects: | Life Sciences > Physiology, Pathophysiology and Endocrinology: Organ physiology, pathophysiology, endocrinology, metabolism, ageing, tumorigenesis, cardiovascular diseases, metabolic syndromes > Molecular aspects of endocrinology | |||||||||
| Department: | Departments > Dipartimento di Medicina (DIMED) | |||||||||
| Depositing User: | Filippo Ceccato | |||||||||
| Date Deposited: | 26 May 2025 06:54 | |||||||||
| Last Modified: | 26 May 2025 06:54 | |||||||||
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| Type of data: | Database | |||||||||
| Collection period: |
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| Resource language: | english | |||||||||
| Metadata language: | english | |||||||||
| Publisher: | Research Data Unipd | |||||||||
| Date: | 4 August 2024 | |||||||||
| Copyright holders: | The Author | |||||||||
| URI: | https://researchdata.cab.unipd.it/id/eprint/1571 |
orcid.org/0000-0003-1456-8716
