Cegolon, Luca and Mirandola, Mattia and Salaris, Claudio and Salvati, Maria Vittoria and Mastrangelo, Giuseppe and Salata, Cristiano (2021) Data referring to the paper: Hypothiocyanite and Hypothiocyanite/Lactoferrin Mixture Exhibit Virucidal Activity In Vitro against SARS-CoV-2. [Data Collection]
Collection description
Abstract: SARS-CoV-2 replicates efficiently in the upper airways during the prodromal stage, resulting in environmental viral shedding from patients with active COVID-19 as well as from asymptomatic individuals. There is a need to find pharmacological interventions to mitigate the spread of COVID-19. Hypothiocyanite and lactoferrin are molecules of the innate immune sys-tem with a large spectrum cidal activity. The Food and Drug Administration and the European Medicines Agency designated the hypothiocyanite and lactoferrin combination as an orphan drug. We report an in vitro study showing that micromolar concentrations of hypothiocyanite exhibit dose- and time-dependent virucidal activity against SARS-CoV-2 and that the latter is slightly enhanced by the simultaneous presence of lactoferrin.
| DOI: |  10.25430/researchdata.cab.unipd.it.00000438 |
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Keywords: | Hypothiocyanite, Lactoferrin, Lactoperoxidase system, ALX-009, SARS-CoV-2, COVID-19 | |||||||||||||||||||||
| Subjects: | Life Sciences > Applied Medical Technologies, Diagnostics, Therapies, and Public Health: Development of treatment of diseases, pharmacology, clinical medicine, regenerative medicine, epidemiology and public for diagnosis, monitoring and tools health > Pharmacology and pharmacogenomics (including drug discovery and design, drug delivery and therapy, toxicology) | |||||||||||||||||||||
| Department: | Departments > Dipartimento di Medicina molecolare (DMM) | |||||||||||||||||||||
| Depositing User: | Cristiano Salata | |||||||||||||||||||||
| Date Deposited: | 24 Feb 2021 13:22 | |||||||||||||||||||||
| Last Modified: | 24 Feb 2021 13:22 | |||||||||||||||||||||
| Creators/Authors: |
|
|||||||||||||||||||||
| Type of data: | Text | |||||||||||||||||||||
| Research funder: | Università degli Studi di Padova | |||||||||||||||||||||
| Research project title: | Antiviral discovery | |||||||||||||||||||||
| Grant number: | DOR | |||||||||||||||||||||
| Collection period: |
|
|||||||||||||||||||||
| Resource language: | English | |||||||||||||||||||||
| Metadata language: | English | |||||||||||||||||||||
| Publisher: | Research Data Unipd | |||||||||||||||||||||
| Related publications: | ||||||||||||||||||||||
| Date: | 18 February 2021 | |||||||||||||||||||||
| Copyright holders: | The Author | |||||||||||||||||||||
| URI: | https://researchdata.cab.unipd.it/id/eprint/438 |
orcid.org/0000-0002-6285-7355
