University of Padua

Data referring to the paper: Hypothiocyanite and Hypothiocyanite/Lactoferrin Mixture Exhibit Virucidal Activity In Vitro against SARS-CoV-2

Cegolon, Luca and Mirandola, Mattia and Salaris, Claudio and Salvati, Maria Vittoria and Mastrangelo, Giuseppe and Salata, Cristiano (2021) Data referring to the paper: Hypothiocyanite and Hypothiocyanite/Lactoferrin Mixture Exhibit Virucidal Activity In Vitro against SARS-CoV-2. [Data Collection]

Related publications

Collection description

Abstract: SARS-CoV-2 replicates efficiently in the upper airways during the prodromal stage, resulting in environmental viral shedding from patients with active COVID-19 as well as from asymptomatic individuals. There is a need to find pharmacological interventions to mitigate the spread of COVID-19. Hypothiocyanite and lactoferrin are molecules of the innate immune sys-tem with a large spectrum cidal activity. The Food and Drug Administration and the European Medicines Agency designated the hypothiocyanite and lactoferrin combination as an orphan drug. We report an in vitro study showing that micromolar concentrations of hypothiocyanite exhibit dose- and time-dependent virucidal activity against SARS-CoV-2 and that the latter is slightly enhanced by the simultaneous presence of lactoferrin.

DOI: 10.25430/researchdata.cab.unipd.it.00000438
Keywords: Hypothiocyanite, Lactoferrin, Lactoperoxidase system, ALX-009, SARS-CoV-2, COVID-19
Subjects: Life Sciences > Applied Medical Technologies, Diagnostics, Therapies, and Public Health: Development of treatment of diseases, pharmacology, clinical medicine, regenerative medicine, epidemiology and public for diagnosis, monitoring and tools health > Pharmacology and pharmacogenomics (including drug discovery and design, drug delivery and therapy, toxicology)
Department: Departments > Dipartimento di Medicina molecolare (DMM)
Depositing User: Cristiano Salata
Date Deposited: 24 Feb 2021 13:22
Last Modified: 24 Feb 2021 13:22
Creators/Authors:
CreatorsEmailORCID
Cegolon, Lucal.cegolon@gmail.comorcid.org/0000-0002-6285-7355
Mirandola, Mattiamattia.mirandola@gmail.comorcid.org/0000-0001-7145-3443
Salaris, Claudioclaudio.salaris@studenti.unipd.itorcid.org/0000-0002-6998-8550
Salvati, Maria Vittoriamariavittoria.salvati@phd.unipd.itorcid.org/0000-0001-8478-0718
Mastrangelo, Giuseppegiuseppe.mastrangelo@unipd.itorcid.org/0000-0003-4204-045X
Salata, Cristianocristiano.salata@unipd.itorcid.org/0000-0002-5136-7406
Type of data: Text
Research funder: Università degli Studi di Padova
Research project title: Antiviral discovery
Grant number: DOR
Collection period:
FromTo
July 2020September 2020
Resource language: English
Metadata language: English
Publisher: Research Data Unipd
Related publications:
Date: 18 February 2021
Copyright holders: The Author
Last Modified: 24 Feb 2021 13:22
URI: https://researchdata.cab.unipd.it/id/eprint/438

Available Files

Data

Cite As

Begin typing (e.g. Chicago or IEEE.) or use the drop down menu.

Begin typing (e.g. en-GB for English, Great Britain) or use the drop down menu.

Export As