University of Padua

An early paradoxical GH increase after glucose load characterises non-acromegalic patients with high IGF-1 levels

Ceccato, Filippo (2022) An early paradoxical GH increase after glucose load characterises non-acromegalic patients with high IGF-1 levels. [Data Collection]

Collection description

Objective: An incomplete GH suppression after oral glucose tolerance test (OGTT) is the hallmark of acromegaly diagnosis. A proportion of patients with acromegaly present a paradoxical GH rise (GH-Par) after glucose administration. We aimed to study if GH-Par response after glucose load can characterize patients without acromegaly. Design: Observational case-control study in a referral centre. Methods: We recruited patients with suspected acromegaly (n=176), characterized by increased IGF-1 levels (GH nadir >0.4 µg/L defined acromegaly), and 55 matched controls (normal IGF-1 and suppressed GH). GH-Par90min was defined as GH peak ≥120% over basal levels at latest 90 minutes after glucose intake.

DOI: 10.25430/researchdata.cab.unipd.it.00000640
Keywords: acromegaly, IGF-1; paradoxical response; oral glucose tolerance test; GIP
Subjects: Life Sciences > Physiology, Pathophysiology and Endocrinology: Organ physiology, pathophysiology, endocrinology, metabolism, ageing, tumorigenesis, cardiovascular diseases, metabolic syndromes > Comparative physiology and pathophysiology
Department: Departments > Dipartimento di Medicina (DIMED)
Depositing User: Filippo Ceccato
Date Deposited: 17 May 2022 09:11
Last Modified: 17 May 2022 09:11
Creators/Authors:
CreatorsEmailORCID
Ceccato, Filippofilippo.ceccato@unipd.itorcid.org/0000-0003-1456-8716
Type of data: Database
Contributors:
ContributionNameEmail
Authorceccato, filippofilippo.ceccato@unipd.it
Collection period:
FromTo
20102020
Geographic coverage: Italy
Resource language: english
Metadata language: english
Publisher: Research Data Unipd
Date: 17 May 2022
Copyright holders: The Author
Last Modified: 17 May 2022 09:11
URI: https://researchdata.cab.unipd.it/id/eprint/640

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