Ceccato, Filippo
(2022)
An early paradoxical GH increase after glucose load characterises non-acromegalic patients with high IGF-1 levels.
[Data Collection]
Collection description
Objective: An incomplete GH suppression after oral glucose tolerance test (OGTT) is the hallmark of acromegaly diagnosis. A proportion of patients with acromegaly present a paradoxical GH rise (GH-Par) after glucose administration. We aimed to study if GH-Par response after glucose load can characterize patients without acromegaly.
Design: Observational case-control study in a referral centre.
Methods: We recruited patients with suspected acromegaly (n=176), characterized by increased IGF-1 levels (GH nadir >0.4 µg/L defined acromegaly), and 55 matched controls (normal IGF-1 and suppressed GH). GH-Par90min was defined as GH peak ≥120% over basal levels at latest 90 minutes after glucose intake.
| DOI: |
 10.25430/researchdata.cab.unipd.it.00000640 |
| Keywords: |
acromegaly, IGF-1; paradoxical response; oral glucose tolerance test; GIP |
| Subjects: |
Life Sciences > Physiology, Pathophysiology and Endocrinology: Organ physiology, pathophysiology, endocrinology, metabolism, ageing, tumorigenesis, cardiovascular diseases, metabolic syndromes > Comparative physiology and pathophysiology |
| Department: |
Departments > Dipartimento di Medicina (DIMED) |
| Depositing User: |
Filippo Ceccato
|
| Date Deposited: |
17 May 2022 09:11 |
| Last Modified: |
17 May 2022 09:11 |
| Creators/Authors: |
|
| Type of data: |
Database |
| Contributors: |
| Contribution | Name | Email |
|---|
| Author | ceccato, filippo | filippo.ceccato@unipd.it |
|
| Collection period: |
|
| Geographic coverage: |
Italy |
| Resource language: |
english |
| Metadata language: |
english |
| Publisher: |
Research Data Unipd |
| Date: |
17 May 2022 |
| Copyright holders: |
The Author |
| URI: |
https://researchdata.cab.unipd.it/id/eprint/640 |
| Creators/Authors: |
|
| Type of data: |
Database |
| Contributors: |
| Contribution | Name | Email |
|---|
| Author | ceccato, filippo | filippo.ceccato@unipd.it |
|
| Collection period: |
|
| Geographic coverage: |
Italy |
| Resource language: |
english |
| Metadata language: |
english |
| Publisher: |
Research Data Unipd |
| Date: |
17 May 2022 |
| Copyright holders: |
The Author |
| Last Modified: |
17 May 2022 09:11 |
|
orcid.org/0000-0003-1456-8716
